Patents by Inventor Yoko Kishimoto

Yoko Kishimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050158330
    Abstract: The present invention provides a W/O/W type oil adjuvant vaccine containing an outer aqueous phase containing 0.5 wt %-20 wt % of a polyethylene glycol derivative having a molecular weight of 400-20,000, and an inner aqueous phase containing a biologically acceptable and effective amount of an antigen. The constitution of the present invention that a polyethylene glycol derivative having a specific molecular weight is contained in the outer aqueous phase enables preparation of a W/O/W type oil adjuvant vaccine showing a high adjuvant effect, reduced side effects such as topical response, superior preparation stability and superior workability to allow a person to give an injection easily due to the lowered viscosity.
    Type: Application
    Filed: December 17, 2004
    Publication date: July 21, 2005
    Applicants: NOF Corporation, Juridical Foundation
    Inventors: Koichi Saito, Yoko Kishimoto, Tokuji Miyahara, Kouzou Takase
  • Publication number: 20040109896
    Abstract: An ophthalmic aqueous suspension preparation to serve as a cure for corneal herpes infection contains 9-[(2-hydroxyethoxy)methyl]guanine as an active ingredient and exhibits an improved stability. Specifically, the ophthalmic aqueous suspension preparation contains 0.2 to 5% by weight of 9-[(2-hydroxyethoxy)methyl]guanine or a pharmaceutically acceptable salt thereof, 0.05 to 1% by weight of a partially saponified product of polyvinyl acetate, and 0.01 to 1% by weight of a nonionic surfactant and has a pH of 6 to 8. Preferably, the fine crystals have a short axis of 50 &mgr;m or less and a long axis of 70 &mgr;m or less in length and have a ratio of the long axis to the short axis of 10:1 or less.
    Type: Application
    Filed: February 2, 2004
    Publication date: June 10, 2004
    Inventors: Kouichi Saitoh, Yoko Kishimoto, Satoru Tokuyama, Susumu Oguro, Isao Hanazome, Tomoyuki Okamoto, Toshio Kasama
  • Patent number: 5814321
    Abstract: A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40.degree. C. and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a non-reducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: September 29, 1998
    Assignees: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, NOF Corporation
    Inventors: Tokuji Miyahara, Kozo Takase, Koichi Saito, Yoko Kishimoto, Satoru Tokuyama