Patents by Inventor Yolanda FERNANDEZ SAINZ

Yolanda FERNANDEZ SAINZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB
    Publication number: 20230139156
    Abstract: The invention relates to a process for the preparation of compounds of formula (I), which are useful intermediates in the synthesis of Upadacitinib and structurally related compounds, by using Weinreb amide (III), or an equivalent thereof, as key intermediate.
    Type: Application
    Filed: December 18, 2020
    Publication date: May 4, 2023
    Inventors: Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN, Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, José Enrique GÓMEZ PULIDO, Mario LADERAS MUÑOZ
  • Process and intermediates for the preparation of benzo[b]thiophene compounds
    Patent number: 11312708
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 26, 2022
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Alfonso Pérez Encabo, José Ángel Turiel Hernandez, Yolanda Fernández Sainz, Antonio Lorente Bonde-Larsen
  • Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
    Patent number: 11117925
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: September 14, 2021
    Assignee: BIONICE, S.L.U.
    Inventors: Antonio Lorente Bonde-Larsen, Ignacio Herraiz Sierra, Yolanda Fernandez Sainz, Jose Luis Barredo Fuente, Alfonso Perez Encabo, Jose Angel Turiel Hernandez
  • Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
    Patent number: 11104702
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: August 31, 2021
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Ignacio Herráiz Sierra, Yolanda Fernández Sainz, Carlos Cordovilla Losada, Alfonso Pérez Encabo, José Angel Turiel Hernandez
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20200262863
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived partially or solely from plant sources.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 20, 2020
    Inventors: Ignacio Herraiz Sierra, Alfonso Pérez Encabo, Antonio Lorente Bonde-Larsen, Francisco Javier Guerra Navarro, Yolanda Fernandez Sainz, José Luis Barredo Fuente, José Angel Turiel Hernandez
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
    Publication number: 20200172523
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Inventors: Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN
  • PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
    Publication number: 20200165289
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Application
    Filed: June 22, 2018
    Publication date: May 28, 2020
    Inventors: Ignacio HERRÁIZ SIERRA, Yolanda FERNANDEZ SAINZ, Carlos CORDOVILLA LOSADA, Alfonso PÉREZ ENCABO, José Angel TURIEL HERNANDEZ
  • Process and intermediates for the preparation of benzo[b]thiophene compounds
    Patent number: 10597386
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 24, 2020
    Assignee: Crystal Pharma, S.A.U.
    Inventors: Alfonso Pérez Encabo, José Ángel Turiel Hernandez, Yolanda Fernández Sainz, Antonio Lorente Bonde-Larsen
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
    Publication number: 20190040048
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Application
    Filed: September 30, 2016
    Publication date: February 7, 2019
    Inventors: Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN
  • METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180305395
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 25, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ
  • Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
    Patent number: 10040765
    Abstract: The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 7, 2018
    Assignee: Crystal Pharma S.A.U.
    Inventors: Antonio Lorente Bonde-Larsen, Yolanda Fernández Sainz, Jesús Iglesias Retuerto, Javier Gallo Nieto
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180086786
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived solely from plant sources.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 29, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ, Francisco Javier GUERRA NAVARRO
  • METHODS FOR THE PREPARATION OF INDACATEROL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20170015628
    Abstract: The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield.
    Type: Application
    Filed: September 28, 2016
    Publication date: January 19, 2017
    Inventors: Antonio Lorente Bonde-Larsen, Yolanda Fernández Sainz, Jesús Iglesias Retuerto, Javier Gallo Nieto
  • Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
    Patent number: 9475772
    Abstract: The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: October 25, 2016
    Assignee: Crystal Pharma S.A.U.
    Inventors: Antonio Lorente Bonde-Larsen, Yolanda Fernández Sainz, Jesús Iglesias Retuerto, Javier Gallo Nieto
  • METHODS FOR THE PREPARATION OF INDACATEROL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20150225346
    Abstract: The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates for the preparation of Indacaterol. The new process avoids the use of the epoxide compound known in the art and the impurities associated therewith and results in a higher yield.
    Type: Application
    Filed: September 9, 2013
    Publication date: August 13, 2015
    Inventors: Antonio Lorente Bonde-Larsen, Yolanda Fernández Sainz, Jesús Iglesias Retuerto, Javier Gallo Nieto
  • Solifenacin salts
    Patent number: 8765785
    Abstract: The invention concerns fumarate salts of solifenacin, as well as pharmaceutical compositions comprising fumarate salts of solifenacin. The invention furthermore concerns a process for preparing solifenacin and salts thereof. The fumarate salt provides improved properties over the known solifenacin salts, especially in terms of its stability. The novel process for its preparation is furthermore improved over known processes for preparing solifenacin in that it provides a higher yield and recovers a greater amount of starting material.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: July 1, 2014
    Assignee: Crystal Pharma, S.A.U.
    Inventors: Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen, Jaime del Campo López-Bachiller, Celso Sandoval Rodríguez, Yolanda Fernández Sainz
  • SOLIFENACIN SALTS
    Publication number: 20130203804
    Abstract: The invention concerns fumarate salts of solifenacin, as well as pharmaceutical compositions comprising fumarate salts of solifenacin. The invention furthermore concerns a process for preparing solifenacin and salts thereof. The fumarate salt provides improved properties over the known solifenacin salts, especially in terms of its stability. The novel process for its preparation is furthermore improved over known processes for preparing solifenacin in that it provides a higher yield and recovers a greater amount of starting material.
    Type: Application
    Filed: July 5, 2011
    Publication date: August 8, 2013
    Applicant: CRYSTAL PHARMA, S.A.U.
    Inventors: Gerardo Gutiérrez Fuentes, Antonio Lorente Bonde-Larsen, Jaime del Campo López-Bachiller, Celso Sandoval Rodríguez, Yolanda Fernández Sainz