Patents by Inventor Yolanda Gutierrez-Puente

Yolanda Gutierrez-Puente has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small oligonucleotides with anti-tumor activity
    Patent number: 7704962
    Abstract: The present invention provides short antisense oligonucleotide compositions and methods for their use in the treatment of Bcl-2-associated diseases like cancer, such as follicular lymphoma (FL). The antisense oligonucleotides contain sequences that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. The use of novel short antisense oligonucleotides, from 7 bases to 9 bases in length, is described in this invention. The invention also describes certain specific sequences which are longer than 9 bases and are 11 or 15 bases long. Used alone, or in conjunction with other antisense oligonucleotides, these antisense oligonucleotide compositions inhibit the proliferation of cancer cells.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: April 27, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ana M. Tari, Gabriel Lopez-Berestein, Yolanda Gutierrez-Puente