Patents by Inventor Yon W. Ebright
Yon W. Ebright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11685723Abstract: The invention provides compounds of formula Ia, Ib, Ic, or as well as compositions comprising a compound of formula Ia-Id, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: February 12, 2019Date of Patent: June 27, 2023Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Richard H. Ebright, Yon W. Ebright
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Patent number: 11572337Abstract: The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.Type: GrantFiled: March 6, 2019Date of Patent: February 7, 2023Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Richard H. Ebright, Yon W. Ebright, Joel S. Freundlich, Ricardo Gallardo-Macias, Shao-Gang Li
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Patent number: 11447502Abstract: The invention provides bipartite, dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y (I) wherein X is an moiety that binds to the Rif target of a bacterial RNA polymerase; Y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and is a covalent bond or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.Type: GrantFiled: May 23, 2019Date of Patent: September 20, 2022Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Chih-Tsung Lin
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Publication number: 20210198279Abstract: The invention provides bipartite, dual-targeted inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y (I) wherein X is an moiety that binds to the Rif target of a bacterial RNA polymerase; Y is a moiety that binds to the bridge-helix N-terminus target of a bacterial RNA polymerase; and is a covalent bond or a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.Type: ApplicationFiled: May 23, 2019Publication date: July 1, 2021Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Chih-Tsung LIN
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Publication number: 20210017126Abstract: The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.Type: ApplicationFiled: March 6, 2019Publication date: January 21, 2021Applicant: Rutgers, The State University of New JerseyInventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Joel S. FREUNDLICH, Ricardo GALLARDO-MACIAS, Shao-Gang LI
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Publication number: 20210002266Abstract: The invention provides salts of formula Ia, Ib, Ic, or Id: wherein variables are as described in the specification, as well as compositions comprising a salt of formula Ia-Id, methods of making such salts, and methods of using such salts as, e.g., inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: February 12, 2019Publication date: January 7, 2021Applicant: Rutgers, the State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Publication number: 20210002246Abstract: The invention provides compounds of formula Ia, Ib, Ic, or as well as compositions comprising a compound of formula Ia-Id, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: February 12, 2019Publication date: January 7, 2021Applicant: Rutgers, the State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Patent number: 9919998Abstract: The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.Type: GrantFiled: February 6, 2015Date of Patent: March 20, 2018Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Soma Mandal, Richard Wilde, Shengjian Li
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Patent number: 9809626Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.Type: GrantFiled: February 17, 2017Date of Patent: November 7, 2017Assignee: Rutgers, the State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
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Publication number: 20170166611Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.Type: ApplicationFiled: February 17, 2017Publication date: June 15, 2017Applicant: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
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Patent number: 9605028Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.Type: GrantFiled: December 17, 2015Date of Patent: March 28, 2017Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
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Patent number: 9592221Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: March 8, 2016Date of Patent: March 14, 2017Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
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Publication number: 20160347708Abstract: The invention provides compounds having activity as bacterial RNA polymerase inhibitors and antibacterial agents, as well as compositions comprising the compounds and methods for their use. Specifically, phenylalanineamide and tyrosinamide compounds are disclosed that have inhibitory activity toward mycobacterium tuberculosis RNA polymerase. Use of these compounds in the treatment or prevention of M. tuberculosis infections in a mammal, is disclosed.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Inventors: Richard H. Ebright, Yon W. Ebright, Soma Mandal, Richard Wilde, Shengjian Li
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Publication number: 20160263083Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: March 8, 2016Publication date: September 15, 2016Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, PROVID PHARMACEUTICALS INC.Inventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Juan SHEN, James BACCI, Anne-Cecile HIEBEL, William SOLVIBILE, Christopher SELF, Gary OLSON
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Publication number: 20160200771Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.Type: ApplicationFiled: December 17, 2015Publication date: July 14, 2016Applicant: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
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Patent number: 9315495Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: June 19, 2013Date of Patent: April 19, 2016Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
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Patent number: 9221880Abstract: The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.Type: GrantFiled: December 12, 2013Date of Patent: December 29, 2015Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
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Patent number: 9187446Abstract: The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and G are as described in the specification, as well as compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: March 22, 2013Date of Patent: November 17, 2015Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Patent number: 9133155Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Ya, Yb, R1, R2, and G are as described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: GrantFiled: September 16, 2011Date of Patent: September 15, 2015Assignee: Rutgers, The State University of New JerseyInventors: Richard H. Ebright, Yon W. Ebright
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Publication number: 20150197512Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.Type: ApplicationFiled: June 19, 2013Publication date: July 16, 2015Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson