Patents by Inventor Yong A. Yu

Yong A. Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLONAL STRAINS OF ATTENUATED VACCINIA VIRUSES AND METHODS OF USE THEREOF
    Publication number: 20230008052
    Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
    Type: Application
    Filed: September 3, 2021
    Publication date: January 12, 2023
    Inventors: Aladar A. SZALAY, Nanhai G. Chen, Yong A. Yu, Qian Zhang
  • Clonal strains of attenuated vaccinia viruses and methods of use thereof
    Patent number: 11149254
    Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: October 19, 2021
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai G. Chen, Yong A. Yu, Qian Zhang
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 10584317
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: March 10, 2020
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Microorganisms for therapy
    Patent number: 10463730
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 5, 2019
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • MODIFIED VACCINIA VIRUS STRAINS FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
    Publication number: 20180195050
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Application
    Filed: March 2, 2018
    Publication date: July 12, 2018
    Inventors: Aladar A. SZALAY, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 9944903
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: April 17, 2018
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • MICROORGANISMS FOR THERAPY
    Publication number: 20170095552
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 6, 2017
    Inventors: Aladar A. SZALAY, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Microorganisms for therapy
    Patent number: 9492534
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: November 15, 2016
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • MODIFIED VACCINIA VIRUS STRAINS FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS
    Publication number: 20150175976
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Application
    Filed: March 4, 2015
    Publication date: June 25, 2015
    Inventors: Aladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Modified vaccinia virus strains for use in diagnostic and therapeutic methods
    Patent number: 9005602
    Abstract: Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: April 14, 2015
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Microorganisms for imaging and/or treatment of tumors
    Patent number: 8865153
    Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 21, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai Chen, Yong A. Yu, Qian Zhang
  • Microorganisms for imaging and/or treatment of tumors
    Patent number: 8852927
    Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 7, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Nanhai Chen, Yong A. Yu, Qian Zhang
  • MICROORGANISMS FOR THERAPY
    Publication number: 20140294891
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Microorganisms for therapy
    Patent number: 8784836
    Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: July 22, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Tatyana Timiryasova, Yong A. Yu, Qian Zhang
  • Vaccinia virus for diagnosis and therapy of tumors
    Patent number: 8642257
    Abstract: Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g. a luminescent or fluorescent protein, and, in a particular embodiment, furthermore (a) DNA sequence(s) encoding (a) protein(s) suitable for tumor therapy and/or elimination of metastatic tumors, e.g. a cytotoxic or cytostatic protein.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: February 4, 2014
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Yong A. Yu, Shahrokh Shabahang, Tatyana Timiryasova
  • Light emitting microorganisms and cells for diagnosis and therapy of tumors
    Patent number: 8586022
    Abstract: Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 19, 2013
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Yong A. Yu, Tatyana Timiryasova, Shahrokh Shabahang
  • Light emitting microorganisms and cells for diagnosis and therapy of tumors
    Patent number: 8568707
    Abstract: Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: October 29, 2013
    Assignee: Genelux Corporation
    Inventors: Aladar A. Szalay, Yong A. Yu, Tatyana Timiryasova, Shahrokh Shabahang
  • Methods for attenuating virus strains for diagnostic and therapeutic uses
    Publication number: 20130273007
    Abstract: Lister strain vaccinia viruses that are encode a modified A34R gene resulting in increased extracellular enveloped virus (EEV) form of the virus and/or increased resistance of the virus to neutralizing antibodies. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Application
    Filed: June 12, 2013
    Publication date: October 17, 2013
    Inventors: Aladar A. Szalay, Yong A. Yu, Nanhai Chen, Qian Zhang
  • Microorganisms for imaging and/or treatment of tumors
    Publication number: 20130129614
    Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
    Type: Application
    Filed: May 10, 2012
    Publication date: May 23, 2013
    Inventors: Aladar A. Szalay, Nanhai Chen, Yong A. Yu, Qian Zhang, Yuman Fong
  • Clonal strains of attenuated vaccinia viruses and methods of use thereof
    Publication number: 20120308484
    Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
    Type: Application
    Filed: April 13, 2012
    Publication date: December 6, 2012
    Inventors: Aladar A. Szalay, Nanhai G. Chen, Yong A. Yu, Qian Zhang