Abstract: Compounds and compositions are provided as inhibitors of the Wnt/beta-catenin pathway and/or activators of the adenosine monophosphate-activated kinase (AMPK) pathway for the treatment of diseases that implicate the same. Such diseases include cancer or a metabolic disease. Cancers that may be treated by these compounds and compositions include adrenocortical cancer, hepatocellular cancer, hepatoblastoma, malignant melanoma, ovarian cancer, Wilm's tumor, Barrett's esophageal cancer, prostate cancer, colon cancer, colorectal cancer, rectal cancer, pancreatic cancer, bladder cancer, breast cancer (e.g. triple negative breast cancer), gastric cancer, head & neck cancer, lung cancer, mesothelioma, cervical cancer, uterine cancer, myeloid leukemia cancer, lymphoid leukemia cancer, pilometricoma cancer, medulloblastoma cancer, glioblastoma, and familial adenomatous polyposis. Metabolic diseases include type 2 diabetes, obesity, hyperlipidemia, alcoholic or non-alcoholic fatty liver disease, and liver fibrosis.

Abstract: A method and apparatus for inspecting a wind turbine blade. The method includes: acquiring a sound signal generated by an impingement of wind on the wind turbine blade using a sound acquisition device; generating a frequency spectrogram corresponding to the sound signal; and obtaining a damage recognition result of the wind turbine blade from the frequency spectrogram by performing image recognition on the frequency spectrogram based on a damage recognition model. With the method, a damage type of the wind turbine blade is accurately recognized based on the frequency spectrogram without manual inspection. Therefore, human resources are saved. In addition, the health state of the wind turbine blade can be monitored in real time.

Abstract: Provided herein are semiconductor packages with improved electrical contacts (e.g. pins). In some embodiments, an assembly may include a substrate and an electrical contact coupled to the substrate, the electrical contact consisting of a first component defined by a complex 3D designed receiving pin. The electrical contact may further include a second component defined by another complex 3D designed penetrating pin, wherein the first component engages the second component to deform mechanically and to weld when the first component and the second component are coupled together.

Abstract: Disclosed are a method and apparatus for detecting a fault, and a method and apparatus for training a model. The method includes: acquiring characteristic data and actual temperature of a first wind turbine among n wind turbines, wherein the characteristic data of the first wind turbine is intended to characterize a working state of the first wind turbine, and n is an integer greater than 1; acquiring a prediction temperature set by inputting the characteristic data of the first wind turbine into a temperature prediction model corresponding to each of the n wind turbines; and detecting, based on the predicted temperature set and the actual temperature of the first wind turbine, whether the first wind turbine encounters a fault.

Abstract: Provided herein are semiconductor packages with improved clamps. In some embodiments, a semiconductor package may include a housing having a wall extending from a main body, and a set of support walls extending from the wall. The semiconductor package may further include a clamp extending between the set of support walls, the clamp having a first planar section coupled to a first support wall of the set of support walls, a second planar section coupled to a second support wall of the set of support walls, and a third planar section between the first and second planar sections. The third planar section may include an opening operable to receive a fastener, and a plurality of stress relief openings.

Abstract: Disclosed are a method and apparatus for detecting a yaw-to-wind abnormality. The method includes: acquiring a wind direction deviation angle within a specified time period; calculating a power performance index, wherein the power performance index is a dimensionless number used to characterize power generation performance of a wind turbine; determining an optimal wind direction deviation angle based on the power performance index; determining a current wind direction deviation angle according to probability distribution of the wind direction deviation angle; and if a difference between the optimal wind direction deviation angle and the current wind direction deviation angle is greater than a preset threshold, determining that a yaw-to-wind abnormality is detected.

Abstract: A method and apparatus for inspecting a wind turbine blade. The method includes: acquiring a sound signal generated by an impingement of wind on the wind turbine blade using a sound acquisition device; generating a frequency spectrogram corresponding to the sound signal; and obtaining a damage recognition result of the wind turbine blade from the frequency spectrogram by performing image recognition on the frequency spectrogram based on a damage recognition model. With the method, a damage type of the wind turbine blade is accurately recognized based on the frequency spectrogram without manual inspection. Therefore, human resources are saved. In addition, the health state of the wind turbine blade can be monitored in real time.

Abstract: Disclosed are a method and apparatus for detecting a yaw-to-wind abnormality. The method includes: acquiring a wind direction deviation angle within a specified time period; calculating a power performance index, wherein the power performance index is a dimensionless number used to characterize power generation performance of a wind turbine; determining an optimal wind direction deviation angle based on the power performance index; determining a current wind direction deviation angle according to probability distribution of the wind direction deviation angle; and if a difference between the optimal wind direction deviation angle and the current wind direction deviation angle is greater than a preset threshold, determining that a yaw-to-wind abnormality is detected.

Abstract: Disclosed are a method and apparatus for detecting a fault, and a method and apparatus for training a model. The method includes: acquiring characteristic data and actual temperature of a first wind turbine among n wind turbines, wherein the characteristic data of the first wind turbine is intended to characterize a working state of the first wind turbine, and n is an integer greater than 1; acquiring a prediction temperature set by inputting the characteristic data of the first wind turbine into a temperature prediction model corresponding to each of the n wind turbines; and detecting, based on the predicted temperature set and the actual temperature of the first wind turbine, whether the first wind turbine encounters a fault.

Abstract: Provided herein are semiconductor packages with improved electrical contacts (e.g. pins). In some embodiments, an assembly may include a substrate and an electrical contact coupled to the substrate, the electrical contact consisting of a first component defined by a complex 3D designed receiving pin. The electrical contact may further include a second component defined by another complex 3D designed penetrating pin, wherein the first component engages the second component to deform mechanically and to weld when the first component and the second component are coupled together.

Abstract: The invention relates to prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof.

Abstract: Provided herein are semiconductor packages with improved clamps. In some embodiments, a semiconductor package may include a housing having a wall extending from a main body, and a set of support walls extending from the wall. The semiconductor package may further include a clamp extending between the set of support walls, the clamp having a first planar section coupled to a first support wall of the set of support walls, a second planar section coupled to a second support wall of the set of support walls, and a third planar section between the first and second planar sections. The third planar section may include an opening operable to receive a fastener, and a plurality of stress relief openings.