Abstract: The present disclosure relates to a polypeptide having multiple directionality and a self-assembled nanostructure containing the same. Since R1 and R3 domains having ?-sheet structures are arranged to have antiparallel structures, it provides a more stabilized ?-helix structure than the existing polypeptide having single directionality. In addition, since the polypeptide of the present disclosure is prepared as an antiparallel pseudo-cyclic structure without additional structural element such as a linker, the associated synthesis process is simple and the molecular weight is relatively small. Since the polypeptide having multiple directionality having the structural and functional characteristics described above and a self-assembled nanostructure containing the same have excellent stability and transportability, they are applicable in various fields as drugs, for detection of substances in vivo, for targeting for drug delivery, and for inhibiting protein-mediated biomacromolecular interactions.

Abstract: The present invention relates to a bioactive carbon nanotube composite functionalized with a ?-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of CNT-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells. Further, the application of the interaction between a ?-sheet peptide and a carbon-based hydrophobic material is expected to be useful for designing and developing an inhibitor for diseases caused by the abnormal folding of a protein and by biomacromolecular interactions (protein-protein, protein-DNA, and protein-RNA interactions etc).