Patents by Inventor Yong Cang

Yong Cang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220324848
    Abstract: The present disclosure discloses a compound shown in formula (II) and a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the compound as an active ingredient, and use thereof in the preparation of medicaments for protein degradation.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 13, 2022
    Inventors: Yunfu LUO, Yong CANG, Bo PENG, Maoyi LEI, Yu XU, Shuhui CHEN
  • Publication number: 20210393501
    Abstract: Provided are purification methods and uses of a recombinant mutant collagenase, and methods for preparing high-purity mutant ColH and the purified enzyme product. The method for preparing high-purity mutant ColH includes expressing recombinant mutant collagenase protein with single mutation of E451D in ColH by using specific host strain E. coli BL21 (DE3), and improving yield of the target protein after induction by low-temperature fermentation. The purification includes five steps: Capto Phenyl HS hydrophobic interaction chromatography; Capto Q anion exchange chromatography; Capto Octyl hydrophobic interaction chromatography; Phenyl HP hydrophobic interaction chromatography and Source 15Q anion exchange chromatography. The target protein obtained has purity of over 98%.
    Type: Application
    Filed: March 12, 2019
    Publication date: December 23, 2021
    Applicant: Rejuven Dermaceutical Co., Ltd.
    Inventors: Yong CANG, Zhen ZHANG, Gang DU, Fuding CHEN
  • Patent number: 10280229
    Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: May 7, 2019
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Chun Sing Li, Jian Li, Yong Cang, Shuhui Chen, Gang Li, Xiongbin Xu, Lun Lu
  • Publication number: 20170202974
    Abstract: The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
    Type: Application
    Filed: July 13, 2015
    Publication date: July 20, 2017
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Chun Sing LI, Jian LI, Yong CANG, Shuhui CHEN, Gang LI, Xiongbin XU, Lun LU
  • Patent number: 8617543
    Abstract: A Clostridium histolyticum collagenase ColH (Glu451Asp) melts adipose tissue when injected into selected regions of the body. This protein product melts fat pads effectively in fat rat experiments, with very little side effects. Very little hemorrhage was observed. We also invent a new version of ColH mutant by linking a peptide motif CKGGRAKDC-G (varying from 2 to 6 Gs) (SEQ ID NO: 2) in front of ColH (Glu451Asp) (called topical ColH-FM), which can target to white fat vasculature. By combining with novel transdermal technology (such as Hydroxysome technology), we develop a topical protein cream that can melt fat. This product can be used as cellulite cream and for chemical liposuction. This topical ColH-FM can also be injected into adipose tissue as a replacement for liposuction or as an adjunct method with liposuction. Since raise scar is formed by overgrowth of collagen, our topical ColH-FM cream is shown to have application in scar reduction.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: December 31, 2013
    Assignee: Yolare Pharmaceuticals, LLC
    Inventors: Lan Huang, Yong Cang, Renato (Rene) Jose
  • Publication number: 20120164131
    Abstract: A Clostridium histolyticum collagenase ColH (Glu451Asp) melts adipose tissue when injected into selected regions of the body. This protein product melts fat pads effectively in fat rat experiments, with very little side effects. Very little hemorrhage was observed. We also invent a new version of ColH mutant by linking a peptide motif CKGGRAKDC-G(varying from 2 to 6 Gs) (SEQ ID NO: 2) in front of ColH (Glu451Asp) (called topical ColH-FM), which can target to white fat vasculature. By combining with novel transdermal technology (such as Hydroxysome technology), we develop a topical protein cream that can melt fat. This product can be used as cellulite cream and for chemical liposuction. This topical ColH-FM can also be injected into adipose tissue as a replacement for liposuction or as an adjunct method with liposuction. Since raise scar is formed by overgrowth of collagen, our topical ColH-FM cream is shown to have application in scar reduction.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 28, 2012
    Inventors: Lang Huang, Yong Cang, Renato (Rene) Jose