Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.

Abstract: The present application provides a hydrophilic and hydrophobic composite packing-based rotating packed bed and a system. A hydrophobic packing and a hydrophilic packing are formed into a composite packing. When said packing cuts liquid, the hydrophobic packing can sufficiently disperse the liquid so as to make the dispersion of the liquid in the packing zone more uniform, and the wettability of the hydrophilic packing allows the liquid to spread sufficiently so as to increase the wetting efficiency of said packing. The phenomenon of droplet aggregation caused to liquid in a single hydrophobic packing zone and the phenomenon of reduction of liquid turbulence caused to liquid in a single hydrophilic packing zone can be avoided. Therefore, applying a hydrophilic and hydrophobic composite packing to a rotating packed bed can further improve the mass transfer and mixing performance thereof.

Abstract: A method for preparing a finerenone intermediate compound of formula I from a diastereomeric tartrate by means of racemic resolution is provided. A compound of formula I having an ee value higher than 99.5% can be obtained. The preparation method provided has mild reaction conditions, simple post-treatment, and no special reagents required, and is suitable for industrial production.

Abstract: A coring device, comprising an electronic sub communicated with a ground control system and identifying the position of a core taken underground, a supporting arm sub for fixing the coring device, a rotating sub for rotating a mechanical sub to a specified position to carry out coring by rotating, a hydraulically controlled sub for providing power to the rotating sub and the mechanical sub, a mechanical sub for performing pushing, coring, core folding and core length measurement operations, and a core storage barrel sub for storing a taken core, which are sequentially connected. The rotating sub comprises a rotating shaft, a moving sleeve which sleeves the rotating shaft and is in threaded connection with the rotating shaft, and a fixed housing; the rotating shaft and the moving sleeve are arranged inside the fixed housing, two ends of the rotating shaft respectively extend from two ends of the fixed housing.

Abstract: The invention discloses a type of compound that can specifically bind to ?-synuclein aggregates represented by Formula I, a radio-labelled compound thereof, a preparation method, and its use. The compound can be used as a tracer for optical imaging of ?-synuclein aggregates in biological samples or in vivo (such as the brain). After radio-labelled, the compound of the invention can be used as a radio imaging tracer for PET, SPECT, and other imaging techniques to realize the detection of ?-synuclein lesions by non-invasive visualization in vivo (such as the brain).

Abstract: A display device including a substrate and a plurality of pixels in a display region of the substrate. Each of the pixels includes first and second sub-pixels, and each of the first and second sub-pixels has a light emitting region for emitting light. The first sub-pixel includes a first light emitting element in the light emitting region and configured to emit visible light. The second sub-pixel includes a second light emitting element in the light emitting region and configured to emit infrared light and a light receiving element configured to receive the infrared light emitted from the second light emitting element to detect a user's touch. The second light emitting element and the light receiving element in the second sub-pixel are electrically insulated from and optically coupled to each other to form a photo-coupler.

Abstract: A pressure sensor includes: a base substrate including an embossed pattern; a first conductive layer disposed on the base substrate; a pressure sensitive material layer disposed on the first conductive layer such that its electrical characteristic is varied corresponding to a strain applied thereto, the pressure sensitive material layer including a dielectric and nanoparticles dispersed in the dielectric; and a second conductive layer disposed on the pressure sensitive material layer, wherein the dielectric and the nanoparticle include materials having pyroelectricities of polarities opposite to each other.

Abstract: Provided is a mask manufacturing method which includes preparing a mask sheet and a frame, stretching the mask sheet, and fixing the stretched mask sheet to the frame, and forming cell openings in the mask sheet fixed to the frame.

Abstract: A display device includes: a substrate; a display element layer on one surface of the substrate and including at least one light emitting element emitting light; and a pixel circuit portion on the display element layer and including at least one transistor electrically connected to the light emitting element, wherein the display element layer includes: a first electrode on the substrate and electrically connected to one end of the light emitting element; a second electrode on the substrate and electrically connected to the other end of the light emitting element; and an insulation layer on the substrate including the second electrode, and having a first opening exposing a portion of the second electrode, and wherein the second electrode is electrically connected to the transistor through the first opening.

Abstract: A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.

Abstract: A display device including a substrate and a plurality of pixels in a display region of the substrate. Each of the pixels includes first and second sub-pixels, and each of the first and second sub-pixels has a light emitting region for emitting light. The first sub-pixel includes a first light emitting element in the light emitting region and configured to emit visible light. The second sub-pixel includes a second light emitting element in the light emitting region and configured to emit infrared light and a light receiving element configured to receive the infrared light emitted from the second light emitting element to detect a user's touch. The second light emitting element and the light receiving element in the second sub-pixel are electrically insulated from and optically coupled to each other to form a photo-coupler.

Abstract: A display device including a substrate and a plurality of pixels in a display region of the substrate. Each of the pixels includes first and second sub-pixels, and each of the first and second sub-pixels has a light emitting region for emitting light. The first sub-pixel includes a first light emitting element in the light emitting region and configured to emit visible light. The second sub-pixel includes a second light emitting element in the light emitting region and configured to emit infrared light and a light receiving element configured to receive the infrared light emitted from the second light emitting element to detect a user's touch. The second light emitting element and the light receiving element in the second sub-pixel are electrically insulated from and optically coupled to each other to form a photo-coupler.

Abstract: Provided is a mask having a plurality of cell areas, each of which has a plurality of through-portions defined therein. The mask includes a mask film including a polymer and a conductive layer disposed on at least one surface of the mask film and including conductive metal or a conductive metal oxide. Accordingly, precision of a deposition process is enhanced while reducing process time and costs in a manufacturing process of the mask, and thus the yield in manufacturing a display panel using the mask is improved. Therefore, the display panel manufactured using the mask may have improved reliability.

Abstract: Provided is a mask manufacturing method which includes preparing a mask sheet and a frame, stretching the mask sheet, and fixing the stretched mask sheet to the frame, and forming cell openings in the mask sheet fixed to the frame.

Abstract: A pressure sensor includes: a base substrate including an embossed pattern; a first conductive layer disposed on the base substrate; a pressure sensitive material layer disposed on the first conductive layer such that its electrical characteristic is varied corresponding to a strain applied thereto, the pressure sensitive material layer including a dielectric and nanoparticles dispersed in the dielectric; and a second conductive layer disposed on the pressure sensitive material layer, wherein the dielectric and the nanoparticle include materials having pyroelectricities of polarities opposite to each other.

Abstract: A method of automatically sequencing or basecalling one or more DNA (deoxyribonucleic acid) molecules of a biological sample is described. The method comprises using a capillary electrophoresis genetic analyzer to measure the biological sample to obtain at least one input trace comprising digital data corresponding to fluorescence values for a plurality of scans. Scan labelling probabilities for the plurality of scans are generated using a trained artificial neural network comprising a plurality of layers including convolutional layers. A basecall sequence comprising a plurality of basecalls for the one or more DNA molecules based on the scan labelling probabilities for the plurality of scans is determined.

Abstract: A pressure sensor includes: a base substrate including an embossed pattern; a first conductive layer disposed on the base substrate; a pressure sensitive material layer disposed on the first conductive layer such that its electrical characteristic is varied corresponding to a strain applied thereto, the pressure sensitive material layer including a dielectric and nanoparticles dispersed in the dielectric; and a second conductive layer disposed on the pressure sensitive material layer, wherein the dielectric and the nanoparticle include materials having pyroelectricities of polarities opposite to each other.

Abstract: Provided is a mask manufacturing method which includes preparing a mask sheet and a frame, stretching the mask sheet, and fixing the stretched mask sheet to the frame, and forming cell openings in the mask sheet fixed to the frame.

Abstract: A display apparatus may include: a base substrate including at least one bending region and a non-bending region adjacent to the bending region and having a flexible property; a circuit device layer on the base substrate, the circuit device layer including a thin film transistor; a display device layer on the circuit device layer, the display device layer including an organic light emitting diode connected to the thin film transistor; an encapsulation layer covering the display device layer and including a first inorganic layer, an organic layer, and a second inorganic layer, which are sequentially stacked; and a groove overlapped with the bending region, the groove penetrating the display device layer and the circuit device layer, and at least one of the first inorganic layer and the second inorganic layer covers the groove.

Abstract: The present disclosure relates to a speaker and a speaker module, and the speaker comprises: a housing and a vibration system housed within the housing, wherein the vibration system comprises a diaphragm and a voice coil, the voice coil is bonded onto a central portion of the diaphragm, and the voice coil has a lead wire; an end surface of the housing connected to a fixed portion of the diaphragm is provided thereon with a conductive portion; a portion of the lead wire located between the fixed portion and the housing is configured to expose the lead wire and form an exposed conductive end, and when the fixed portion is fixedly connected to the housing, the exposed conductive end is crimped onto the conductive portion and is electrically connected to the conductive portion.