Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: A ray scanning apparatus, including: a conveying device; a ray source assembly including a plurality of ray source modules arranged around the scanning area in a non-enclosed structure opened on one side of the scanning area; and a detector assembly including a plurality of detector sets arranged around the scanning area in a non-enclosed structure opened on one side of the scanning area, where the opening of the non-enclosed structure of the ray source assembly is opposite to the opening of the non-enclosed structure of the detector assembly, the plurality of detector sets are fixed in a same plane perpendicular to the conveying direction of the object under inspection, and the plurality of ray source modules of the ray source assembly are arranged in a plurality of different planes perpendicular to the conveying direction of the object under inspection.

Abstract: Embodiments of the present application provides a ray scanning apparatus, which includes: a conveying device for conveying an object under inspection to pass through a scanning region of the ray scanning apparatus; a ray source assembly including a plurality of ray source modules, each of the ray source modules including at least one ray source point emitting a ray beam; and a detector assembly for detecting rays transmitting through the object under inspection during scanning and including a plurality of detector sets.

Abstract: The present application provides mask plate, fabrication method thereof, and mask plate assembly. The mask plate includes two opening areas being respectively on different sides of mask pattern area along first direction, and two welding areas. One welding area is on a side of one opening area away from the mask pattern area along first direction, and the other welding area is on a side of the other opening area away from mask pattern area along first direction. Evaporation holes are arranged in mask unit, buffer holes are arranged in each opening area, and ratio of maximum dimension of buffer hole in any direction in plane where the mask plate is located to maximum dimension of evaporation hole in the direction is greater than 100. Buffer holes are distributed at equal intervals along a second direction, and second direction is in the plane and is perpendicular to first direction.

Abstract: Aspects of the disclosure are directed to a method for use on a blockchain network that includes an accounting node subnetwork having accounting nodes configured to record a data block onto a blockchain and a service node having service nodes configured to verify data blocks recorded by the accounting nodes onto the blockchain. The method can include generating a signature based on transaction information to be included in a data block to be added onto the blockchain by using a key specific to the accounting node. The method can further include adding the transaction information and the generated signature to the data block and adding the data block onto the blockchain, and transmitting the signature to the service nodes in the service node subnetwork, so that the service nodes perform signature verification on the signature based on the key specific to the accounting node.

Abstract: This application provide a data management method performed at a blockchain system. The system includes an accounting node sub-network and a service node sub-network. The method includes: generating a first data block in the accounting node sub-network; adding first key information to a block header of the first data block; adding signature corresponding to the first data block to the block header of the first data block; and releasing the block header of the first data block to the service node sub-network. The service node sub-network is configured to verify the signature comprised in the block header of the first data block, and obtain the first key information after a successful verification.

Abstract: The present disclosure relates to the field of biotechnology, and in particular to an application of inhibitors targeting CD226 molecules in anti-tumor metastasis. In view of the important role of platelets in mediating tumor metastasis, the present disclosure develops small-molecule inhibitors with blocking effects by targeting CD226 molecules, an important target. It can destroy the interaction between platelets and tumor cells, and inhibit the metastasis of tumor cells, and it is important for research and development of new methods to control tumor metastasis.

Abstract: A 3D camera and a photographing method thereof are provided. The 3D camera includes an image 1 photographing unit and an image 2 photographing unit in the same optical system and a processing system that processes data of the image 1 photographing unit and the image 2 photographing unit. The processing system includes a control unit that controls image photographing by the image 1 photographing unit and the image 2 photographing unit, a recording and storage unit that performs processing on the control unit, and a 3D coordinate calculation unit that performs calculation on the recording and storage unit. 3D coordinates of an object point in 3D space or all space object points constituting a 3D object directly facing the camera are calculated by simultaneously photographing one or more pairs of images for the object point in the 3D space or all space object points constituting the 3D object.

Abstract: Aspects of the disclosure are directed to a method for use on a blockchain network that includes an accounting node subnetwork having accounting nodes configured to record a data block onto a blockchain and a service node having service nodes configured to verify data blocks recorded by the accounting nodes onto the blockchain. The method can include generating a signature based on transaction information to be included in a data block to be added onto the blockchain by using a key specific to the accounting node. The method can further include adding the transaction information and the generated signature to the data block and adding the data block onto the blockchain, and transmitting the signature to the service nodes in the service node subnetwork, so that the service nodes perform signature verification on the signature based on the key specific to the accounting node.

Abstract: This application provide a data management method for a blockchain system, a medium, and an electronic device. The system includes an accounting node sub-network and a service node sub-network. The method includes: adding, after an accounting node generates a first data block, first key information used for verifying a block header of a second data block generated after the first data block to a block header of the first data block; generating a signature corresponding to the first data block, and adding the signature corresponding to the first data block to the block header of the first data block; and releasing the block header of the first data block to the service node sub-network, to cause a service node to verify the signature included in the block header of the first data block, and obtaining the first key information after a successful verification to verify the block header of the second data block.

Abstract: An energy efficient process for NGL recovery and production of compressed natural gas (CNG) in which natural gas is fed to a first gas separation membrane-based separation stage where it is separated into a permeate and a retentate. The high C3+ concentration first stage permeate is chilled and separated to provide liquid phase NGL and a gaseous phase. The first stage retentate is separated at a second gas membrane-based separation stage to produce a retentate meeting pipeline specifications for CNG (including hydrocarbon dewpoint) and a permeate that is recycled to the first stage. The gaseous phase, constituting a low BTU fuel, may be used in on-site power generation equipment and/or in internal combustion engines. The second stage permeate (and optionally the third stage retentate) is (are) recycled back to the first stage to enhance the production of NGL and CNG.

Abstract: The invention relates to a process for recovering methane from digester biogas or landfill gas. More specifically, the invention pertains to a method for producing biomethane that removes impurities from a compressed digester biogas with staged membrane modules of at least two different types, to produce a biomethane having at least 94% CH4, below 3% of CO2, and below 4 ppm of H2S.

Abstract: A method for electing a representative node device is performed at a blockchain system, including: obtaining voting transaction data from the node devices, the voting transaction data being used for voting for one or more node devices of the blockchain system as representative node devices; generating and storing the voting transaction data into a target blockchain of the blockchain system when a plurality of node devices of the blockchain system verify the voting transaction data by consensus; and when a quantity of blocks in the target blockchain generated using the voting transaction data reaches a preset quantity, determining an election result according to quantities of votes of the node devices determined from the voting transaction data, the election result identifying a plurality of representative node devices in the blockchain system being configured to generate new blocks for the target blockchain and perform verification on the new blocks by consensus.

Abstract: The present disclosure discloses a method and equipment for classifying hepatocellular carcinoma images by combining computer vision features and radiomics features, wherein the method comprising: 1) collecting eligible clinical images of patients and preprocessing the collected images; 2) extracting computer vision features from a segmented image of a hepatic tumor region; 3) extracting the manual radiomics features from the segmented image of the hepatic tumor region; 4) by combining the computer vision features and the radiomics features, screening by univariate filtering and then by LASSO regression; 5) using the features resulted from screening and clinical features together for modeling by a multivariable logistic regression model, and using the Akaike information criterion (AIC) to search backward and select clinical features suitable for the best model, so as to implement the prediction of hepatocellular carcinoma pathological grading.

Abstract: An online matching and optimization method combining geometry and texture and a three-dimensional (3D) scanning system are provided. The method includes obtaining pairs of depth texture images with a one-to-one corresponding relationship, and collecting the pairs of the depth texture images including depth images by a depth sensor and collecting texture images by a camera device; adopting a strategy of coarse to fine to perform feature, matching on the depth texture images corresponding to a current frame and on the depth texture images corresponding to the target frames, to estimate a preliminary pose of the depth sensor in the 3D scanning system; combining a geometric constraint and a texture constraint to optimize the estimated preliminary pose, and obtaining a refined motion estimation between the frames.

Abstract: An energy efficient process for NGL recovery and production of compressed natural gas (CNG) in which natural gas is fed to a first gas separation membrane-based separation stage where it is separated into a permeate and a retentate. The high C3+ concentration first stage permeate is chilled and separated to provide liquid phase NGL and a gaseous phase. The first stage retentate is separated at a second gas membrane-based separation stage to produce a retentate meeting pipeline specifications for CNG (including hydrocarbon dewpoint) and a permeate that is recycled to the first stage. The gaseous phase, constituting a low BTU fuel, may be used in on-site power generation equipment and/or in internal combustion engines. The second stage permeate (and optionally the third stage retentate) is (are) recycled back to the first stage to enhance the production of NGL and CNG.

Abstract: A 3D camera and a photographing method thereof are provided. The 3D camera includes an image 1 photographing unit and an image 2 photographing unit in the same optical system and a processing system that processes data of the image 1 photographing unit and the image 2 photographing unit. The processing system includes a control unit that controls image photographing by the image 1 photographing unit and the image 2 photographing unit, a recording and storage unit that performs processing on the control unit, and a 3D coordinate calculation unit that performs calculation on the recording and storage unit. 3D coordinates of an object point in 3D space or all space object points constituting a 3D object directly facing the camera are calculated by simultaneously photographing one or more pairs of images for the object point in the 3D space or all space object points constituting the 3D object.

Abstract: A bridge structure dynamic response of a bridge structure under the action of heavy duty vehicle load is obtained through sensors arranged on the bridge structure; according to vertical vibration acceleration ao and vertical deflection yo of the bridge at a center of gravity o of the heavy duty vehicle and speed of the heavy duty vehicle Uvehicle, a response of a table top of a vibration table is reconstructed, and interaction force of the vehicle-bridge coupling model is obtained; a nonlinear finite element model of the bridge structure is established, and the vehicle-bridge interaction force is taken as external force, and the dynamic response of the bridge structure is taken as a structural response, and modification of the finite element model of the bridge structure is completed through a nonlinear parameter identification method. The invention is mainly used for updating a bridge model.

Abstract: Porous solid amine adsorbents are prepared by bringing into contact a first (e.g., dope) solution, including a water insoluble polymer and a water-soluble amine polymer, with an aqueous solution containing a multifunctional chemical agent. The first solution can be obtained by dissolving the water insoluble polymer and the water-soluble amine polymer in a polar solvent. The adsorbents can be in the form of beads, sheets, fibers, hollow fibers, etc. and can be used in the removal of acid gases, CO2, for instance, from fluid streams.

Abstract: An adsorbent device includes adsorbent fibers laid along or wound around a center tube. In a specific example, the adsorbent fibers are porous solid amine adsorbent fibers. A module for purifying a raw fluid includes one or more adsorbent devices that can be installed in a vessel in series or in parallel. The module can be configured for axial or cross flow operation and can be employed to purify a gas containing a contaminant such as an acid gas. In some implementations, the module is provided with one or more heating elements that can be used to release adsorbed contaminant to regenerate the adsorbent fibers.