Patents by Inventor Yong-Doo Choi
Yong-Doo Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240123092Abstract: Provided is a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and a composition for photodynamic diagnosis or treatment including the same. The conjugate generates no fluorescent signal and reactive oxygen in normal tissues or during the circulation in the blood by quenching a fluorescent signal and reactive oxygen generation ability of the photosensitizer. After the conjugate is selectively absorbed into target cells, a linker is degraded in cells to increase the distance between tryptophan included in the peptide and the photosensitizer, and the quenching action is terminated to generate a strong fluorescence signal and induce active generation of reactive oxygen. The conjugate has high tissue permeability, shows a high photodynamic therapeutic effect in only target cells while being safe in normal cells, and can obtain a good diagnostic image having a high ratio of target signal to background.Type: ApplicationFiled: September 15, 2023Publication date: April 18, 2024Applicant: NATIONAL CANCER CENTERInventors: Yong-Doo CHOI, Ji-Su Kim, Hyun Jin Kim
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Patent number: 11813332Abstract: The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment including the same.Type: GrantFiled: July 4, 2017Date of Patent: November 14, 2023Assignee: NATIONAL CANCER CENTERInventors: Yong-Doo Choi, Ji-Su Kim
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Patent number: 11213595Abstract: The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis. The fluorescent dye comprises a covalently labeled antibody and is quenched by interaction with an amino acid residue such as tryptophan, tyrosine, histidine, and methionine in the antibody and upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis. When using the antibody-fluorescent dye conjugate according to the present invention during in vitro cell assays, high-throughput screening of cells, and cytodiagnosis based on microfluidics, the presence of cancer cells having a specific antigen expressed thereon can be detected at high specificity and sensitivity without a washing process, and the position of primary and metastatic cancer cells can be detected at high contrast within a short time.Type: GrantFiled: September 21, 2018Date of Patent: January 4, 2022Assignee: National Cancer CenterInventors: Yong-Doo Choi, Hyun-Jin Kim
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Publication number: 20210369875Abstract: The present invention provides an alginic acid-based injectable hydrogel system for labeling an accurate position of a disease lesion and effectively delivering a drug to a target region. The formulation of the present invention can make it easy to locally inject a contrast agent and a drug into a target region while controlling the release rate of the contrast agent or the drug, with the formation of the hydrogel in the injected region. Through the advantages, the labeled position can be accurately determined from images, thereby enhancing the precision of surgical operation, with a minimal incision formed therefor. In addition, when used, the alginic acid-based injectable hydrogel system allows the effective local delivery of a drug to a target region while increasing the long-acting effect of the drug.Type: ApplicationFiled: November 1, 2019Publication date: December 2, 2021Applicant: National Cancer CenterInventors: Yong Doo CHOI, Seon Sook LEE, Hyun Jin KIM, Dae Kyung SOHN, Seok Ki KIM, Young Woo KIM, Keun Won RYU, Hong Man YOON
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Patent number: 10894095Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.Type: GrantFiled: December 19, 2019Date of Patent: January 19, 2021Assignee: NATIONAL CANCER CENTERInventors: Dae Kyung Sohn, Yong Doo Choi, Kwang Gi Kim
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Publication number: 20200171175Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.Type: ApplicationFiled: December 19, 2019Publication date: June 4, 2020Inventors: Dae Kyung SOHN, Yong Doo CHOI, Kwang Gi KIM
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Publication number: 20200147217Abstract: The present invention relates to a fucoidan-based theragnostic composition, and more particularly, to preparation and use of a theragnostic composition which uses a conjugate of a fluorescent dye or a photosensitizer and fucoidan, thereby not only allowing for fluorescence imaging diagnosis of lesions for cancer or vascular diseases but also allowing a therapeutic effect thereon to be obtained at the same time. The conjugate obtained by covalent bonding of a fluorescent dye or a photosensitizer and fucoidan, according to the present invention, is not only useful for fluorescence imaging diagnosis of tumor tissues and ophthalmic vascular diseases, but also may exhibit a therapeutic effect on cancer cells and coronary artery smooth muscle cells, and a neovascularization inhibitory effect in ophthalmic diseases.Type: ApplicationFiled: November 7, 2019Publication date: May 14, 2020Applicant: National Cancer CenterInventors: Yong Doo CHOI, Mi Hyeon Cho, Yan Li
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Publication number: 20200054751Abstract: The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment including the same.Type: ApplicationFiled: July 4, 2017Publication date: February 20, 2020Applicant: NATIONAL CANCER CENTERInventors: Yong-Doo Choi, Ji-Su Kim
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Patent number: 10548992Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.Type: GrantFiled: April 7, 2015Date of Patent: February 4, 2020Assignee: NATIONAL CANCER CENTERInventors: Dae Kyung Sohn, Yong Doo Choi, Kwang Gi Kim
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Publication number: 20190091349Abstract: The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis, wherein the fluorescent dye comprises a covalently labeled antibody and is structured to be quenched by interaction with an amino acid residues in the antibody, selected from the group consisting of tryptophan, tyrosine, histidine, and methionine, and to be dequenched upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis.Type: ApplicationFiled: September 21, 2018Publication date: March 28, 2019Inventors: Yong-Doo Choi, Hyun-Jin Kim
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Patent number: 10085950Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.Type: GrantFiled: February 26, 2015Date of Patent: October 2, 2018Assignee: National Cancer CenterInventors: Soo Youl Kim, Jong Heon Kim, Young Ki Bae, Ho Lee, Hyon Chol Jang, Yong-Doo Choi, Kyeong Man Hong, Dong Wan Hong
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Publication number: 20170071877Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.Type: ApplicationFiled: February 26, 2015Publication date: March 16, 2017Inventors: Soo Youl KIM, Jong Heon KIM, Young Ki BAE, Ho LEE, Hyon Chol JANG, Yong-Doo CHOI, Kyeong Man HONG, Dong Wan HONG
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Publication number: 20170028086Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.Type: ApplicationFiled: April 7, 2015Publication date: February 2, 2017Inventors: Dae Kyung SOHN, Yong Doo CHOI, Kwang Gi KIM
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Patent number: 9339557Abstract: Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.Type: GrantFiled: October 8, 2009Date of Patent: May 17, 2016Assignee: NATIONAL CANCER CENTERInventors: Yong-Doo Choi, Bo-Seung Jang, In-Hoo Kim, Jin-Young Park
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Patent number: 9095613Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.Type: GrantFiled: October 28, 2009Date of Patent: August 4, 2015Assignee: NATIONAL CANCER CENTERInventors: Yong-Doo Choi, Bo-Seung Jang, Jin-Young Park, Jung-Im Lee, In-Hoo Kim
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Patent number: 8688195Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.Type: GrantFiled: November 4, 2009Date of Patent: April 1, 2014Assignee: National Cancer CenterInventors: Dae-Kyung Sohn, Kwang-Gi Kim, Yong-Doo Choi, Kyoung-Won Nam, Hyun-Ho Kim
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Publication number: 20120014874Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.Type: ApplicationFiled: October 28, 2009Publication date: January 19, 2012Inventors: Yong-Doo Choi, Bo-seung Jang, JIn-Young Park, Jung-Im Lee, In-Hoo Kim
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Publication number: 20110293728Abstract: Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.Type: ApplicationFiled: October 8, 2009Publication date: December 1, 2011Inventors: Yong-Doo Choi, Bo-Seung Jang, In-Hoo Kim, Jin-Young Park
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Publication number: 20100331674Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.Type: ApplicationFiled: November 4, 2009Publication date: December 30, 2010Inventors: Dae-Kyung Sohn, Kwang-Gi Kim, Yong-Doo Choi, Kyoung-Won Nam, Hyun-Ho Kim
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Patent number: 6764698Abstract: The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block copolymer having both hydrophilic and hydrophobic groups.Type: GrantFiled: March 28, 2001Date of Patent: July 20, 2004Assignees: Kwangju Institute of Science & Technology, Shin Poong Pharmaceutical Co., Ltd.Inventors: Young-Ro Byun, Sang-Yoon Kim, Sun-Hee Kim, Yong-Doo Choi, In-Suk Han, Kwang-Sun Lee, Chul-Hee Kim