Patents by Inventor Yong-Doo Choi

Yong-Doo Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11213595
    Abstract: The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis. The fluorescent dye comprises a covalently labeled antibody and is quenched by interaction with an amino acid residue such as tryptophan, tyrosine, histidine, and methionine in the antibody and upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis. When using the antibody-fluorescent dye conjugate according to the present invention during in vitro cell assays, high-throughput screening of cells, and cytodiagnosis based on microfluidics, the presence of cancer cells having a specific antigen expressed thereon can be detected at high specificity and sensitivity without a washing process, and the position of primary and metastatic cancer cells can be detected at high contrast within a short time.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: January 4, 2022
    Assignee: National Cancer Center
    Inventors: Yong-Doo Choi, Hyun-Jin Kim
  • Publication number: 20210369875
    Abstract: The present invention provides an alginic acid-based injectable hydrogel system for labeling an accurate position of a disease lesion and effectively delivering a drug to a target region. The formulation of the present invention can make it easy to locally inject a contrast agent and a drug into a target region while controlling the release rate of the contrast agent or the drug, with the formation of the hydrogel in the injected region. Through the advantages, the labeled position can be accurately determined from images, thereby enhancing the precision of surgical operation, with a minimal incision formed therefor. In addition, when used, the alginic acid-based injectable hydrogel system allows the effective local delivery of a drug to a target region while increasing the long-acting effect of the drug.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 2, 2021
    Applicant: National Cancer Center
    Inventors: Yong Doo CHOI, Seon Sook LEE, Hyun Jin KIM, Dae Kyung SOHN, Seok Ki KIM, Young Woo KIM, Keun Won RYU, Hong Man YOON
  • Patent number: 10894095
    Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: January 19, 2021
    Assignee: NATIONAL CANCER CENTER
    Inventors: Dae Kyung Sohn, Yong Doo Choi, Kwang Gi Kim
  • Publication number: 20200171175
    Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 4, 2020
    Inventors: Dae Kyung SOHN, Yong Doo CHOI, Kwang Gi KIM
  • Publication number: 20200147217
    Abstract: The present invention relates to a fucoidan-based theragnostic composition, and more particularly, to preparation and use of a theragnostic composition which uses a conjugate of a fluorescent dye or a photosensitizer and fucoidan, thereby not only allowing for fluorescence imaging diagnosis of lesions for cancer or vascular diseases but also allowing a therapeutic effect thereon to be obtained at the same time. The conjugate obtained by covalent bonding of a fluorescent dye or a photosensitizer and fucoidan, according to the present invention, is not only useful for fluorescence imaging diagnosis of tumor tissues and ophthalmic vascular diseases, but also may exhibit a therapeutic effect on cancer cells and coronary artery smooth muscle cells, and a neovascularization inhibitory effect in ophthalmic diseases.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 14, 2020
    Applicant: National Cancer Center
    Inventors: Yong Doo CHOI, Mi Hyeon Cho, Yan Li
  • Publication number: 20200054751
    Abstract: The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment including the same.
    Type: Application
    Filed: July 4, 2017
    Publication date: February 20, 2020
    Applicant: NATIONAL CANCER CENTER
    Inventors: Yong-Doo Choi, Ji-Su Kim
  • Patent number: 10548992
    Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: February 4, 2020
    Assignee: NATIONAL CANCER CENTER
    Inventors: Dae Kyung Sohn, Yong Doo Choi, Kwang Gi Kim
  • Publication number: 20190091349
    Abstract: The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis, wherein the fluorescent dye comprises a covalently labeled antibody and is structured to be quenched by interaction with an amino acid residues in the antibody, selected from the group consisting of tryptophan, tyrosine, histidine, and methionine, and to be dequenched upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 28, 2019
    Inventors: Yong-Doo Choi, Hyun-Jin Kim
  • Patent number: 10085950
    Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: October 2, 2018
    Assignee: National Cancer Center
    Inventors: Soo Youl Kim, Jong Heon Kim, Young Ki Bae, Ho Lee, Hyon Chol Jang, Yong-Doo Choi, Kyeong Man Hong, Dong Wan Hong
  • Publication number: 20170071877
    Abstract: The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol and phenformin was verified to have a significantly higher anticancer activity than a single treatment with gossypol and phenformin alone. Therefore, the pharmaceutical composition of the present invention containing gossypol and phenformin having a synergetic anticancer activity can be favorably used for cancer treatment.
    Type: Application
    Filed: February 26, 2015
    Publication date: March 16, 2017
    Inventors: Soo Youl KIM, Jong Heon KIM, Young Ki BAE, Ho LEE, Hyon Chol JANG, Yong-Doo CHOI, Kyeong Man HONG, Dong Wan HONG
  • Publication number: 20170028086
    Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
    Type: Application
    Filed: April 7, 2015
    Publication date: February 2, 2017
    Inventors: Dae Kyung SOHN, Yong Doo CHOI, Kwang Gi KIM
  • Patent number: 9339557
    Abstract: Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: May 17, 2016
    Assignee: NATIONAL CANCER CENTER
    Inventors: Yong-Doo Choi, Bo-Seung Jang, In-Hoo Kim, Jin-Young Park
  • Patent number: 9095613
    Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 4, 2015
    Assignee: NATIONAL CANCER CENTER
    Inventors: Yong-Doo Choi, Bo-Seung Jang, Jin-Young Park, Jung-Im Lee, In-Hoo Kim
  • Patent number: 8688195
    Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: April 1, 2014
    Assignee: National Cancer Center
    Inventors: Dae-Kyung Sohn, Kwang-Gi Kim, Yong-Doo Choi, Kyoung-Won Nam, Hyun-Ho Kim
  • Publication number: 20120014874
    Abstract: Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanoparticle and charged with a second charge having an opposite polarity to the first charge. During circulation in blood, the photosensitizer-metal nanoparticle charge complex is maintained in a complex type, and thus duration of a side effect of photosensitivity can be reduced. In a tumor tissue, the complex is specifically accumulated, but in a normal tissue, it is difficult for the complex to penetrate. Thus, the complex can selectively destroy the tumor tissue. Moreover, selective fluorescence in the tumor tissue can provide further improvement in accuracy of diagnosing a tumor using the complex.
    Type: Application
    Filed: October 28, 2009
    Publication date: January 19, 2012
    Inventors: Yong-Doo Choi, Bo-seung Jang, JIn-Young Park, Jung-Im Lee, In-Hoo Kim
  • Publication number: 20110293728
    Abstract: Provided are a photosensitizer-metal nanoparticle complex and a composition for photodynamic therapy or diagnosis having the same. The complex includes a photosensitizer, a metal nanoparticle, and a backbone linking the photosensitizer with the metal nanoparticle. The backbone has a polypeptide substrate capable of being specifically degraded by a protease. When the complex is administered to a patient, fluorescence and production of reactive oxygen species from the conjugated photosensitizers are inhibited in normal tissues due to the resonance energy transfer between the photosensitizer and metal nanoparticles, but in tumor tissues, fluorescence and production of reactive oxygen species from the released photosensitizers are activated, thereby effectively destroying the tumor tissues. In addition, the selective fluorescence in the tumor tissues can further improve accuracy of tumor diagnosis using the protease-activatable photosensitizer-metal nanoparticle complex.
    Type: Application
    Filed: October 8, 2009
    Publication date: December 1, 2011
    Inventors: Yong-Doo Choi, Bo-Seung Jang, In-Hoo Kim, Jin-Young Park
  • Publication number: 20100331674
    Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.
    Type: Application
    Filed: November 4, 2009
    Publication date: December 30, 2010
    Inventors: Dae-Kyung Sohn, Kwang-Gi Kim, Yong-Doo Choi, Kyoung-Won Nam, Hyun-Ho Kim
  • Patent number: 6764698
    Abstract: The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block copolymer having both hydrophilic and hydrophobic groups.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: July 20, 2004
    Assignees: Kwangju Institute of Science & Technology, Shin Poong Pharmaceutical Co., Ltd.
    Inventors: Young-Ro Byun, Sang-Yoon Kim, Sun-Hee Kim, Yong-Doo Choi, In-Suk Han, Kwang-Sun Lee, Chul-Hee Kim