Abstract: Provided herein are methods of classifying lesions in medical image of subjects in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: A pixel circuit, a display panel and a method for driving the pixel circuit. The pixel circuit includes a first light emission control module and a gate initialization module. The first light emission control module includes a control terminal, a first terminal and a second terminal, where the control terminal of the first light emission control module is electrically connected with a first light emission control signal, the first terminal of the first light emission control module is electrically connected with a first power signal, and the second terminal of the first light emission control module is electrically connected to the first electrode of the drive transistor.

Abstract: An ultrasonic blood flow imaging display method and an ultrasonic imaging system. The system comprises: a probe (1); a transmitting circuit (2), configured to excite the probe (1) to transmit an ultrasonic beam to a scanning target; a receiving circuit (4) and a beam forming module (5), configured to receive an echo of the ultrasonic beam to obtain an ultrasonic echo signal; a data processing module (9), configured to obtain, according to the ultrasonic echo signal, blood flow velocity vector information and Doppler blood flow velocity information about a target point in the scanning target and at least part of ultrasonic images of the scanning target, and superposing the ultrasonic images and the Doppler blood flow velocity information to form a Doppler color blood flow graph; and a display (8), configured to contrastively display the blood flow velocity vector information and the Doppler color blood flow graph.

Abstract: An array substrate and a display panel. The array substrate includes a thin film transistor array layer including a driving transistor, a switching transistor, and a capacitor. The driving transistor includes a first active layer, a first gate insulating layer, a first gate, and an insulating dielectric layer sequentially stacked. The switching transistor includes a second active layer, a second gate insulating layer, and a second gate sequentially stacked. The insulating dielectric layer and the second gate insulating layer are located at a same layer. A thickness of the first gate insulating layer is greater than a thickness of the second gate insulating layer. The capacitor includes a first electrode plate and a second electrode plate. The first electrode plate and the first gate are disposed on same layer, and the second electrode plate and the second gate are disposed on same layer.

Abstract: A catalyst for continuous production of 1,1,1,3-tetrachloropropane through gas-solid reaction as well as a preparation method and use thereof are provided. The catalyst includes a zero-valent iron and phosphorus co-modified carbon material which includes a carbon material as a carrier, a zero-valent iron supported onto the carrier and serving as an active component, and a phosphate functional group formed on the surface of the carbon material. The preparation method includes: co-modifying a carbon material using a ferric salt and organic phosphorus to obtain the catalyst for continuous production of 1,1,1,3-tetrachloropropane through gas-solid reaction. The present application further provides a method for continuous production of 1,1,1,3-tetrachloropropane through gas-solid reaction.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: A humidifying device includes a housing, a humidifying module, and a water spray module disposed above the wet membrane assembly. The housing includes an air inlet, an air outlet, and an installation socket at an end of the housing. The humidifying module includes a water receiving portion and a wet membrane assembly disposed in the water receiving portion, and the water receiving portion is disposed in the installation socket in a pluggable manner. The wet membrane assembly includes a water receiving tray on a top thereof, and the water receiving tray includes a plurality of first through holes. The water spray module includes a water spray board, a water spray cover, and a water inlet assembly connected with the water spray cover. A water storage chamber exits between the water spray board and the water spray cover. The water spray board includes a plurality of second through holes.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating medical images that include the use of a generative adversarial network (GAN) in certain embodiments. Related methods, systems, and computer program products are also provided.

Abstract: The present invention provides a rare earth hard alloy and a preparation method and application thereof. The rare earth hard alloy includes 6 to 15 wt % of a binding phase and the balance of a hard phase, wherein the binding phase includes 30 to 50 wt % of Ni3Al, 0.1 to 0.5 wt % of a rare earth element and the balance of Ni. According to the rare earth hard alloy provided by the invention, the Ni—Ni3Al-rare earth element (e.g., Ni—Ni3Al—Y)-based binding phase is strengthened by Ni3Al, and an ordered strengthening phase is formed and is diffused and distributed in the binding phase, such that the rare earth hard alloy has a better high-temperature oxidation resistance, a better room-temperature fracture toughness and a better high-temperature bending strength than a conventional hard alloy.

Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo.

Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

Abstract: A cleaner useful in removing undesirable polymeric material deposits adhered within small bore holes of electronic components is provided, as well as apparatus and methods for carrying out cleaning of such components.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for machine learning image reconstruction. In some implementations, first input data representing the image of the one or more internal structures generated using a first imaging device is provided as input to a first machine learning model having one or more fully-connected layers. First output data generated by the first machine learning model is obtained and the first output data together with second input data representing a second image of the one or more internal structures generated using a second imaging device is provided to a second machine learning model having one or more convolutional layers. Second output data generated by the second machine learning model is obtained and used to generate rendering data that, when processed by a computing device, causes the computing device to output a reconstructed image.

Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

Abstract: A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Abstract: A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.

Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo.