Patents by Inventor Yong Du

Yong Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250076105
    Abstract: A dual-port optical transmitting and receiving assembly, comprising an optical transmitting group, an optical circulator, a light turning element, a first input/output terminal, a second input/output terminal, and an optical receiving group. The first input/output terminal and the second input/output terminal are disposed in a spaced arrangement. A first signal light emitted from the optical transmitting group passes through the optical circulator and enters the first input/output terminal. A second signal light emitted from the optical transmitting group passes through the optical circulator. Then, it enters the second input/output terminal after being reflected by the light turning element. A third signal light from the first input/output terminal passes through the optical circulator and enters the optical receiving group. A fourth signal light from the second input/output terminal is reflected by the light turning element and enters the optical receiving group after passing through the optical circulator.
    Type: Application
    Filed: August 29, 2024
    Publication date: March 6, 2025
    Inventors: Yan-Bing Zhang, Yong Du, Yi Liao, Jinyuan Qiao, Xiao Feng Xiong, Jian-Long Huang
  • Publication number: 20240408216
    Abstract: A protein inhibitor or degrading agent, a pharmaceutical composition comprising same and a pharmaceutical use. Provided are a compound represented by general formula (I), and a pharmaceutical composition containing same. Also disclosed are an application of the compound of the general formula as a protein inhibitor and/or a protein degrading agent and a pharmaceutical use.
    Type: Application
    Filed: June 27, 2022
    Publication date: December 12, 2024
    Inventors: Guozhong YE, Yong DU, Yuhua George ZHANG, Jinju CHEN, Shaojun CHEN, Zhi LIU, Yongfeng CHEN, Cunliang ZHAO, Yao LIU, Tao FANG, Miao YU, Xiaorong LU, Yuxia WANG, Zhaofu WANG, Qiang WU, Desheng KONG, Li ZHANG
  • Patent number: 12165036
    Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
    Type: Grant
    Filed: December 7, 2023
    Date of Patent: December 10, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yong Du, Kevin H. Leung, Martin Gilbert Pomper
  • Publication number: 20240370700
    Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 7, 2024
    Inventors: Yong DU, Kevin H. LEUNG, Martin Gilbert POMPER
  • Patent number: 12125266
    Abstract: An anchor-free object detection method based on ultraviolet image includes: obtaining a ground-truth label of object detection, two label boxes corresponding to the two labels; obtaining a masked label based on the two labels and the two label boxes in the train set, and performing a same enhancement processing on the train set and the masked label; constructing an anchor-free object detection model including an encoding part, a decoding part and a detection head part including three detection heads, namely two anchor-free detection heads and one anchor-free dual-head detection head, and the dual-head of the anchor-free box dual-head detection head is an anchor-free detection head and an auxiliary detection head, respectively; training the model based on the enhanced train set and the enhanced masked label; and inputting the ultraviolet image data to be detected into the final anchor-free object detection model, to obtain an object detection result.
    Type: Grant
    Filed: July 12, 2024
    Date of Patent: October 22, 2024
    Assignees: State Grid Hubei Extra High Voltage Company, Hubei Superenergic Electric Power Co., Ltd.
    Inventors: Shenli Wang, Song Xie, Yong Du, Jiang Liu, Jun Wu, Yi Shi, Wei Zhao, Qian Wang
  • Publication number: 20240337410
    Abstract: A fresh air integrated machine includes a housing, a fresh air channel, a circulating air channel, an air mixing cavity, a first heat exchanger, and a second heat exchanger. The fresh air channel is configured to introduce outdoor air into the air mixing cavity. The circulating air channel is configured to introduce indoor air into the air mixing cavity. The first heat exchanger is disposed in the fresh air channel and configured to adjust humidity and temperature of air in the fresh air channel. The second heat exchanger is disposed in the circulating air channel and configured to adjust humidity and temperature of air in the circulating air channel.
    Type: Application
    Filed: June 21, 2024
    Publication date: October 10, 2024
    Applicant: QINGDAO HISENSE HITACHI AIR-CONDITIONING SYSTEMS CO., LTD.
    Inventors: Lihua CHI, Qinghao MENG, Yong DU, Zhen WANG, Moxuan YANG, Zhigang ZHOU
  • Publication number: 20240143033
    Abstract: The present disclosure provides a flexible substrate, a flexible display device having the same, and a preparation method thereof. The flexible substrate includes a first flexible material layer, light extraction isolation structures, and a plurality of light extraction layers; the light extraction isolation structures are disposed on a surface of the first flexible material layer to form a plurality of light extraction regions isolated from each other between the light extraction isolation structures; the plurality of light extraction layers are disposed one-to-one respectively in at least past of the plurality of the light extraction regions, so that each of the light extraction layers corresponding to different wavelengths of incident light has different improvement ratios of light extraction efficiency when the different wavelengths of incident light passes through each of the light extraction layers.
    Type: Application
    Filed: October 10, 2020
    Publication date: May 2, 2024
    Inventors: Yong DU, Xinyan GU
  • Publication number: 20240127433
    Abstract: Provided herein are methods of classifying lesions in medical image of subjects in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: February 18, 2022
    Publication date: April 18, 2024
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yong DU, Martin Gilbert POMPER, Steven P. ROWE, Kevin H. LEUNG
  • Publication number: 20240119263
    Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: December 7, 2023
    Publication date: April 11, 2024
    Inventors: Yong DU, Kevin H. LEUNG, Martin Gilbert POMPER
  • Patent number: 11886975
    Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: January 30, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yong Du, Kevin H. Leung, Martin Gilbert Pomper
  • Publication number: 20240003557
    Abstract: A humidifying device includes a housing, a humidifying module, and a water spray module disposed above the wet membrane assembly. The housing includes an air inlet, an air outlet, and an installation socket at an end of the housing. The humidifying module includes a water receiving portion and a wet membrane assembly disposed in the water receiving portion, and the water receiving portion is disposed in the installation socket in a pluggable manner. The wet membrane assembly includes a water receiving tray on a top thereof, and the water receiving tray includes a plurality of first through holes. The water spray module includes a water spray board, a water spray cover, and a water inlet assembly connected with the water spray cover. A water storage chamber exits between the water spray board and the water spray cover. The water spray board includes a plurality of second through holes.
    Type: Application
    Filed: September 15, 2023
    Publication date: January 4, 2024
    Applicant: QINGDAO HISENSE HITACHI AIR-CONDITIONING SYSTEMS CO., LTD.
    Inventors: Detong YU, Yong DU, Chuanyong LIU, Chuan LI, Qinghao MENG
  • Publication number: 20230342591
    Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: November 15, 2021
    Publication date: October 26, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yong DU, Kevin H. LEUNG, Martin Gilbert POMPER
  • Publication number: 20230342921
    Abstract: Provided herein are methods of generating medical images that include the use of a generative adversarial network (GAN) in certain embodiments. Related methods, systems, and computer program products are also provided.
    Type: Application
    Filed: July 21, 2021
    Publication date: October 26, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yong DU, Kevin H. LEUNG, Martin Gilbert POMPER, Steven P. ROWE, Wenyi SHAO
  • Patent number: 11788174
    Abstract: The present invention provides a rare earth hard alloy and a preparation method and application thereof. The rare earth hard alloy includes 6 to 15 wt % of a binding phase and the balance of a hard phase, wherein the binding phase includes 30 to 50 wt % of Ni3Al, 0.1 to 0.5 wt % of a rare earth element and the balance of Ni. According to the rare earth hard alloy provided by the invention, the Ni—Ni3Al-rare earth element (e.g., Ni—Ni3Al—Y)-based binding phase is strengthened by Ni3Al, and an ordered strengthening phase is formed and is diffused and distributed in the binding phase, such that the rare earth hard alloy has a better high-temperature oxidation resistance, a better room-temperature fracture toughness and a better high-temperature bending strength than a conventional hard alloy.
    Type: Grant
    Filed: May 30, 2023
    Date of Patent: October 17, 2023
    Assignees: Central South University, JiangXi University of Science and Technology
    Inventors: Yong Du, Jian Lv, Keke Chang, Weibin Zhang, Ming Lou, Zepeng Li, Yangqing Lv
  • Publication number: 20230265143
    Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo.
    Type: Application
    Filed: March 21, 2022
    Publication date: August 24, 2023
    Inventors: Haitao Wang, Yong Du, Rui Zhang, Jing Xu, Longbin Liu
  • Publication number: 20230241241
    Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 3, 2023
    Applicant: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert ZHAO, Qingliang YANG, Hangbo YE, Yuanyuan HUANG, Yifang XU, Gengxiang ZHAO, Diancheng CHEN, Huihui GUO, Xiangfei KONG, Wenjun LI, Lu BAI, Xiang CAI, Xiuzhen ZHANG, Junxiang JIA, Zhixiang GUO, Shangma HUANG, Xiaoxu WANG, Jun ZHENG, Yong DU, Yanhua LI, Yunxia ZHENG, Chen LIN, Xiaoxiao CHEN, Wei ZHENG, Xinyan JIANG, Lingli ZHANG, Riping YE, Miaomiao CHEN
  • Publication number: 20230193169
    Abstract: A cleaner useful in removing undesirable polymeric material deposits adhered within small bore holes of electronic components is provided, as well as apparatus and methods for carrying out cleaning of such components.
    Type: Application
    Filed: February 10, 2023
    Publication date: June 22, 2023
    Inventors: William Gregory Kozak, Yong Du
  • Publication number: 20230177746
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for machine learning image reconstruction. In some implementations, first input data representing the image of the one or more internal structures generated using a first imaging device is provided as input to a first machine learning model having one or more fully-connected layers. First output data generated by the first machine learning model is obtained and the first output data together with second input data representing a second image of the one or more internal structures generated using a second imaging device is provided to a second machine learning model having one or more convolutional layers. Second output data generated by the second machine learning model is obtained and used to generate rendering data that, when processed by a computing device, causes the computing device to output a reconstructed image.
    Type: Application
    Filed: May 7, 2021
    Publication date: June 8, 2023
    Inventors: Wenyi Shao, Martin Gilbert Pomper, Yong Du
  • Publication number: 20230115871
    Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
    Type: Application
    Filed: June 24, 2019
    Publication date: April 13, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Linyao ZHAO, Yuanyuan HUANG, Hangbo YE, Shun GAI, Junxiang JIA, Lu BAI, Wenjun LI, Zhixiang GUO, Chen LIN, Jun ZHENG, Huihui GUO, Minjun CAO, Xiangfei KONG, Yong DU, Yifang XU, Xiaomai ZHOU, Hongsheng XIE, Xiuzhen ZHANG, Miaomiao CHEN, Xiaolei LIU, Xiang CAI, Binbin CHEN, Yanlei YANG, Lingli ZHANG
  • Publication number: 20230057350
    Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 23, 2023
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Jun LEI, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Shun GAI, Mingjun CAO, Qianqian TONG, Lu BAI, Zhixiang GUO, Chengyu YANG, Xiaomai ZHOU, Hongsheng XIE, Yifang XU, Huihui GUO, Junxiang JIA, Jun ZHENG, Cheng LIN, Xiaotao ZHUO, Wenjun LI, Yong DU, Xiangfei KONG, Binbin CHEN, Yanlei YANG, Yanhong TONG, Xiaoxiao CHEN, Yanhua LI, Xiuzheng ZHANG, Juan LAI