Abstract: A dual-port optical transmitting and receiving assembly, comprising an optical transmitting group, an optical circulator, a light turning element, a first input/output terminal, a second input/output terminal, and an optical receiving group. The first input/output terminal and the second input/output terminal are disposed in a spaced arrangement. A first signal light emitted from the optical transmitting group passes through the optical circulator and enters the first input/output terminal. A second signal light emitted from the optical transmitting group passes through the optical circulator. Then, it enters the second input/output terminal after being reflected by the light turning element. A third signal light from the first input/output terminal passes through the optical circulator and enters the optical receiving group. A fourth signal light from the second input/output terminal is reflected by the light turning element and enters the optical receiving group after passing through the optical circulator.

Abstract: A protein inhibitor or degrading agent, a pharmaceutical composition comprising same and a pharmaceutical use. Provided are a compound represented by general formula (I), and a pharmaceutical composition containing same. Also disclosed are an application of the compound of the general formula as a protein inhibitor and/or a protein degrading agent and a pharmaceutical use.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: An anchor-free object detection method based on ultraviolet image includes: obtaining a ground-truth label of object detection, two label boxes corresponding to the two labels; obtaining a masked label based on the two labels and the two label boxes in the train set, and performing a same enhancement processing on the train set and the masked label; constructing an anchor-free object detection model including an encoding part, a decoding part and a detection head part including three detection heads, namely two anchor-free detection heads and one anchor-free dual-head detection head, and the dual-head of the anchor-free box dual-head detection head is an anchor-free detection head and an auxiliary detection head, respectively; training the model based on the enhanced train set and the enhanced masked label; and inputting the ultraviolet image data to be detected into the final anchor-free object detection model, to obtain an object detection result.

Abstract: A fresh air integrated machine includes a housing, a fresh air channel, a circulating air channel, an air mixing cavity, a first heat exchanger, and a second heat exchanger. The fresh air channel is configured to introduce outdoor air into the air mixing cavity. The circulating air channel is configured to introduce indoor air into the air mixing cavity. The first heat exchanger is disposed in the fresh air channel and configured to adjust humidity and temperature of air in the fresh air channel. The second heat exchanger is disposed in the circulating air channel and configured to adjust humidity and temperature of air in the circulating air channel.

Abstract: The present disclosure provides a flexible substrate, a flexible display device having the same, and a preparation method thereof. The flexible substrate includes a first flexible material layer, light extraction isolation structures, and a plurality of light extraction layers; the light extraction isolation structures are disposed on a surface of the first flexible material layer to form a plurality of light extraction regions isolated from each other between the light extraction isolation structures; the plurality of light extraction layers are disposed one-to-one respectively in at least past of the plurality of the light extraction regions, so that each of the light extraction layers corresponding to different wavelengths of incident light has different improvement ratios of light extraction efficiency when the different wavelengths of incident light passes through each of the light extraction layers.

Abstract: Provided herein are methods of classifying lesions in medical image of subjects in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: A humidifying device includes a housing, a humidifying module, and a water spray module disposed above the wet membrane assembly. The housing includes an air inlet, an air outlet, and an installation socket at an end of the housing. The humidifying module includes a water receiving portion and a wet membrane assembly disposed in the water receiving portion, and the water receiving portion is disposed in the installation socket in a pluggable manner. The wet membrane assembly includes a water receiving tray on a top thereof, and the water receiving tray includes a plurality of first through holes. The water spray module includes a water spray board, a water spray cover, and a water inlet assembly connected with the water spray cover. A water storage chamber exits between the water spray board and the water spray cover. The water spray board includes a plurality of second through holes.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: Provided herein are methods of generating medical images that include the use of a generative adversarial network (GAN) in certain embodiments. Related methods, systems, and computer program products are also provided.

Abstract: The present invention provides a rare earth hard alloy and a preparation method and application thereof. The rare earth hard alloy includes 6 to 15 wt % of a binding phase and the balance of a hard phase, wherein the binding phase includes 30 to 50 wt % of Ni3Al, 0.1 to 0.5 wt % of a rare earth element and the balance of Ni. According to the rare earth hard alloy provided by the invention, the Ni—Ni3Al-rare earth element (e.g., Ni—Ni3Al—Y)-based binding phase is strengthened by Ni3Al, and an ordered strengthening phase is formed and is diffused and distributed in the binding phase, such that the rare earth hard alloy has a better high-temperature oxidation resistance, a better room-temperature fracture toughness and a better high-temperature bending strength than a conventional hard alloy.

Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo.

Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

Abstract: A cleaner useful in removing undesirable polymeric material deposits adhered within small bore holes of electronic components is provided, as well as apparatus and methods for carrying out cleaning of such components.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for machine learning image reconstruction. In some implementations, first input data representing the image of the one or more internal structures generated using a first imaging device is provided as input to a first machine learning model having one or more fully-connected layers. First output data generated by the first machine learning model is obtained and the first output data together with second input data representing a second image of the one or more internal structures generated using a second imaging device is provided to a second machine learning model having one or more convolutional layers. Second output data generated by the second machine learning model is obtained and used to generate rendering data that, when processed by a computing device, causes the computing device to output a reconstructed image.

Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.