Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

Abstract: A voice broadcast method includes: acquiring at least one piece of voice information; delivering the at least one piece of voice information to a voice broadcast device, wherein, the at least one piece of voice information includes voice identification information and a voice content; determining a first voice content to be broadcast by the voice broadcast device, wherein the first voice content is included in the at least one piece of voice information stored at the voice broadcast device; and sending, to the voice broadcast device, a first voice identification information corresponding to the first voice content, wherein the first voice identification information is used by the voice broadcast device to obtain the first voice content stored at the voice broadcast device, and to broadcast the first voice content when a preset voice broadcast condition is met.

Abstract: One embodiment of the present invention includes a parallel processing unit (PPU) that performs pixel shading at variable granularities. For effects that vary at a low frequency across a pixel block, a coarse shading unit performs the associated shading operations on a subset of the pixels in the pixel block. By contrast, for effects that vary at a high frequency across the pixel block, fine shading units perform the associated shading operations on each pixel in the pixel block. Because the PPU implements coarse shading units and fine shading units, the PPU may tune the shading rate per-effect based on the frequency of variation across each pixel group. By contrast, conventional PPUs typically compute all effects per-pixel, performing redundant shading operations for low frequency effects. Consequently, to produce similar image quality, the PPU consumes less power and increases the rendering frame rate compared to a conventional PPU.

Abstract: Inter-layer motion mapping information may be used to enable temporal motion vector prediction (TMVP) of an enhancement layer of a bitstream. For example, a reference picture and a motion vector (MV) of an inter-layer video block may be determined. The reference picture may be determined based on a collocated base layer video block. For example, the reference picture may be a collocated inter-layer reference picture of the reference picture of the collocated base layer video block. The MV may be determined based on a MV of the collocated base layer video block. For example, the MV may be determined by determining the MV of the collocated base layer video block and scaling the MV of the collocated base layer video block according to a spatial ratio between the base layer and the enhancement layer. TMVP may be performed on the enhancement layer picture using the MV of the inter-layer video block.

Abstract: A check valve including a first housing having a first seat; a dart disposed at least partially within the first housing and interactive with the seat to selectively create a fluid seal; a second housing disposed at least partially about the first housing, the second housing having a second seat, the first housing interactive with the second seat to selectively create a fluid seal; a first biasing member configured to bias the dart to a sealed position with the first seat; and a second biasing member configured to bias the first housing to a sealed position with the second seat.

Abstract: A method of controlling deposit buildup comprises generating a gas by reacting an active material in a gas generating element with a fluid that contacts the gas generating element; and controlling deposit buildup with the generated gas.

Abstract: An adaptable anchor includes a frame; an arm articulated to the frame; a pad connected to the arm at a distance from the articulation with the frame; a wedge movably mounted to the frame and in wedging contact with the arm; a biasing member disposed to selectively apply a biasing energy between the frame and the wedge; and a degradable retainer preventing application of the biasing energy until degraded. An embodiment of a borehole system includes a borehole in a subsurface formation; a tubular member disposed in the borehole; and an adaptable anchor as in any prior embodiment in operable contact with the tubular member. An embodiment of a method for anchoring a tool in a borehole includes running the adaptable anchor into a borehole; degrading the degradable retainer; urging the wedge into contact with the arm with the biasing member; and displacing the pad.

Abstract: A piece of text is saved for security verification on a computing device. One or more pieces of related text corresponding to the piece of saved text are generated, where each text element of the one or more pieces of related text is generated based on its proximity to the corresponding text element of the piece of saved text on one or more keyboards on the computing device. A piece of input text is received for information verification. A piece of input text is compared with the piece of saved text and the one or more pieces of related text. A determination is made that the piece of input text matches one of the one or more pieces of related text and input guidance for re-entering a piece of text for security authentication is provided.

Abstract: A method applied to a terminal device includes displaying a first home screen, detecting a preset first input, opening, in response to the first input, a first application, displaying a screen of the first application, where the first input is an input of a user for opening the first application, detecting a preset second input, displaying a second home screen in response to the second input, where the second home screen is a home screen on which an icon of the first application is located, where the preset second input is an input of the user for exiting the screen of the first application, and the first home screen is different from the second home screen.

Abstract: Aerodynamic aquatic weed removal and decontamination devices and decontamination methods are disclosed. In an embodiment, the aerodynamic aquatic weed removal and decontamination device includes a boat body and a shore-based device for remotely controlling the boat body. The boat body includes a power unit, a weed removal and decontamination unit, a positioning system, an environment perception system, and a shipborne controller. The power unit includes an engine, a propeller connected to the engine, and a rudder servo motor configured to control a heading of the boat body. The weed removal and decontamination unit includes a mesh conveyor. The positioning system includes a positioner configured to obtain real-time location information and heading information of the boat body. The environment perception system includes a wind sensor and a visual sensor. The shipborne controller is configured to control a navigation state of the boat body.

Abstract: A retrievable in-flow control device (ICD) including a device body having a first end, a second end, an outer surface extending between the first end and the second end, and an internal flow path. A wireline connector is arranged at the first end. A latch mechanism is provided on one of the wireline connector and the device body. A flow control port extends through the outer surface to the internal flow path. An equalizer member including a first flow path for passing a first fluid and a second flow path for resisting flow of a second fluid. The retrievable ICD also includes a flow control device establishes a selected pressure drop of the first fluid through the retrievable ICD.

Abstract: The present invention relates to processes for preparing compounds of Formula (I) and Formula (II): These compounds are useful as FXR or TGR5 modulators.

Abstract: The present invention relates to compounds of Formulas 3-6, where R4 PG1 and PG2 are defined as disclosed herein. These compounds are useful as intermediates in processes for preparing a compound of Formula I: where R1 is defined as disclosed herein.

Abstract: The present invention discloses an agricultural aircraft for spreading granular fertilizer and a spreading method thereof. The agricultural aircraft includes an aircraft body, a power system, and a spreading device, where the spreading device is located at a front part of the aircraft body, and the aircraft body is also provided at the front thereof with a wind direction sensor and a wind speed sensor communicatively connected a controller; the spreading device includes a box body, a throwing disc, and a tray connected to the box body, where a left baffle plate and a right baffle plate with controllable opening angles are disposed on the tray; an upper part of the box body is a material box for storing granular fertilizer, a cavity for accommodating the tray and the throwing disc is disposed on one side of the box body.

Abstract: Inter-layer motion mapping information may be used to enable temporal motion vector prediction (TMVP) of an enhancement layer of a bitstream. For example, a reference picture and a motion vector (MV) of an inter-layer video block may be determined. The reference picture may be determined based on a collocated base layer video block. For example, the reference picture may be a collocated inter-layer reference picture of the reference picture of the collocated base layer video block. The MV may be determined based on a MV of the collocated base layer video block. For example, the MV may be determined by determining the MV of the collocated base layer video block and scaling the MV of the collocated base layer video block according to a spatial ratio between the base layer and the enhancement layer. TMVP may be performed on the enhancement layer picture using the MV of the inter-layer video block.

Abstract: Systems and methods described herein provide for rendering and quality monitoring of rendering of a 360-degree video, where the video has a plurality of representations with different levels of quality in different regions. In an exemplary method, a client device tracks a position of a viewport with respect to the 360-degree video and renders to the viewport a selected set of the representations. The client adaptively adds and removes representations from the selected set based on the viewport position. The client also measures and reports a viewport switching latency. In some embodiments, the latency for a viewport switch is a comparable-quality viewport switch latency that represents the time it takes after a viewport switch to return to a quality comparable to the pre-switch viewport quality.

Abstract: The present invention discloses a method and an apparatus for measuring leaf nitrogen content (LNC), and belongs to the spectral analysis and artificial intelligence (AI) field. The method includes the following steps: (1) obtaining a single-band image of a target leaf illuminated by a light source in a single feature band; (2) repeating step (1), to collect image information in four feature bands; (3) combining the collected images in the four feature bands into a four-channel spectral image; (4) training a deep learning model by using the spectral image and a corresponding nitrogen content label, to obtain a nitrogen content prediction model; (5) transplanting the trained nitrogen content prediction model into an AI control system; (6) collecting information about a to-be-predicted leaf sample, predicting nitrogen content by using an AI sensor equipped with the AI control system, and outputting the predicted nitrogen content.

Abstract: Systems, methods, and instrumentalities are disclosed for client centric service quality control. A first viewport of a 360 degree video may be determined. The 360 degree video may comprise one or more of an equirectangular, a cube-map, a cylindrical, a pyramidal, and/or a spherical projection mapping. The first viewport may be associated with a spatial region of the 360 degree video. An adjacent area that extends around the spatial region may be determined. A second viewport of the 360 degree video may be determined. A bitstream associated with the 360 degree video may be received. One or more enhanced regions may be included in the bitstream. The one or more enhanced regions may correspond to the first and/or second viewport. A high coding bitrate may be associated with the first viewport and/or the second viewport.

Abstract: A method for rapid and quantitative determination of sildenafil in cocktail includes the exemplary steps of: Step 1, assigning a Raman spectrum of sildenafil; Step 2, weighing and dissolving a sildenafil standard in methanol to obtain a 1,000 mg/L sildenafil standard solution, and mixing cocktails with the sildenafil standard solution, to prepare test solutions; Step 3, mixing 100 ?L each of test solutions with 500 ?L of surface enhancer OTR 202 to acquire Raman spectra; and Step 4, establishing a linear regression model, with a formula of y=4035.1 x+503.26, where y is the content of sildenafil in cocktail, in mg/L, and x is intensity of Raman characteristic peaks at 1584 cm?1. Rapid determination of sildenafil by SERS is feasible and reliable, serving as a novel, rapid, and accurate method for quantitative determination of sildenafil in cocktail. The method meets the requirements of analysis and detection of sildenafil in other alcoholic beverages.

Abstract: A subsurface valve including a valve body having an inlet, and outlet, and a valve portion. A plunger is shiftably mounted in the valve body to selectively fluidically connect the inlet and the outlet. A valve system is arranged in the valve portion. The valve system includes a fixed member comprising a magnet and a moveable member shiftably mounted in the valve body and mechanically connected to the plunger. A control system is operatively connected to the fixed member. The control system is operable to selectively adjust a magnetic flux of the magnet to shift the moveable member and the plunger.