Abstract: An air conditioner for a vehicle with an improved structure so that hot air is not directly discharged to a defrost vent in a floor mode or a mix mode, includes an air conditioning case in which an air flow path is formed, and a cooling heat exchanger and a heating heat exchanger provided sequentially on the air flow path of the air conditioning case in an airflow direction, wherein a defrost vent, a face vent, and a floor vent are formed on the air conditioning case, wherein the defrost vent includes a first defogging flow path allowing air passing through the heating heat exchanger to be discharged directly, and a second defogging flow path allowing air passing through the cooling heat exchanger or the heating heat exchanger to be mixed and discharged therethrough.

Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Abstract: Disclosed herein is a method for producing a cyst-expressed transgenic animal using a PDK2 gene. The production method comprises preparing a PKD2 protein expression vector, inserting the expression vector into the nucleus of a fertilized egg to produce a PKD2 expression vector-containing fertilized egg, and transplanting the produced fertilized egg into the uterus of a surrogate mother. According to the invention disclosed herein, there is provided a method for producing transgenic animals, in which cysts are expressed only by the overexpression of the PKD2 gene. Also, transgenic mice are provided which can be effectively used in the investigation of cyst expression mechanisms and cyst control systems.