Abstract: A high-quality voice signal processing device through removal of ambient noise based on multi-sensor signal fusion, includes: a voice microphone sensor that senses and outputs a speaker's voice signal; an accelerometer sensor that senses vibration of the speaker's vocal cords and outputs a signal; a noise reduction processing MCU that extracts a voice section according to vocal cord vibration using the output signal of the accelerometer sensor, synthesizes a low-frequency component of the accelerometer sensor and a low-frequency component of the voice microphone sensor at different synthesis ratios based on a level of noise extracted from the output signal of the voice microphone sensor using voice section information, and restores and outputs a voice signal by adding the synthesized low-frequency components and a high-frequency component of the voice microphone sensor; and a wireless communication module that externally outputs the restored voice signal.