Abstract: New and useful neurostimulation systems are provided that include an implantable pulse generator dimensioned and configured for implantation in the skull of a patient. The implantable pulse generator has an electrode operatively associated with a distal end portion thereof and can be provided with adjustment means, such as an adjustable biasing member or spring arranged between the electrode to the distal end portion of the pulse generator. Also provided are systems involving networked neurostimulators that are configured and adapted to work jointly in accordance with prescribed treatment protocol to effect a desired recovery from brain injury. Such networked neurostimulation systems are particularly advantageous for effecting relatively large and/or relatively distant regions of the brain. Additionally, systems and methods for motor-evoked potential (MEP)-based neuromodulation are provided. Further, AC and/or DC stimulation can be utilized, depending on the precise implementation.

Abstract: An epidural cortical stimulation system includes a stimulation body and a connecting lead. The stimulation body has a core formed of a shape-memory material, insulation provided around the core, defining an outer surface of the stimulation body, and at least one electrode arranged on the outer surface of the stimulation body, adapted and configured to contact the dura of a patient. The connecting lead extends from a proximal end of the body, and is adapted and configured for electrical communication with a control unit for providing power to the body electrical cortical stimulation.

Abstract: A self-expandable epidural cortical electrode includes an electrically conductive expandable body and a connecting lead extending from the body. The body has an insulating layer on a first side and at least one region on a second side without an insulating layer. The connecting lead is adapted and configured for electrical communication with a control unit for providing power to the body electrical cortical stimulation.

Abstract: The subject invention is directed to new and useful neurostimulation systems that include an implantable pulse generator dimensioned and configured for implantation in the skull of a patient. The implantable pulse generator has an electrode operatively associated with a distal end portion thereof and can be provided with adjustment means, such as an adjustable biasing member or spring arranged between the electrode to the distal end portion of the pulse generator. The subject invention is also directed to systems involving networked neurostimulators that are configured and adapted to work jointly in accordance with prescribed treatment protocol to effect a desired recovery from brain injury. Such networked neurostimulation systems are particularly advantageous for effecting relatively large and/or relatively distant regions of the brain. The subject invention is further directed to systems and methods for motor-evoked potential (MEP)-based neuromodulation.