Patents by Inventor Yong Ji Chung

Yong Ji Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10738081
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: August 11, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Publication number: 20200246473
    Abstract: The present invention relates to a compound having a structure in which isotretinoin is linked to a peptide via a covalent bond and an antibiotic, anti-inflammatory, or anti-oxidative pharmaceutical or cosmetic composition comprising the same. A compound having a structure in which isotretinoin is linked to a peptide via a covalent bond according to the present invention exhibits excellent physiological activity such as antibiotic, anti-inflammatory, or anti-oxidative actions, as well as having outstanding properties, such as solubility in water, etc., and thus can find useful applications in various fields including medicines, cosmetics, etc.
    Type: Application
    Filed: May 11, 2018
    Publication date: August 6, 2020
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji CHUNG, Eun Mi KIM
  • Patent number: 10723777
    Abstract: The present disclosure relates to peptides exhibiting an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fats as well as an outstanding anti-diabetes effect by effectively lowering blood sugar levels. The peptides that downregulate the expression of the adipogenic markers PPAR?, ACC and/or aP2, upregulate the expression of the lipolytic factors pHSL, AMPK-?1, CGI-58 and/or ATGL, and reduce sizes of adipocyte and levels of cholesterol in blood are described. The excellent activity and stability of the peptides described herein provides advantages in applications such as drugs and quasi-drug products.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: July 28, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Patent number: 10695279
    Abstract: The present invention provides a peptide having skin-whitening activity. The peptide of the present invention exhibits an excellent skin whitening effect by inhibiting melanogenesis, inhibiting the activity of tyrosinase, inhibiting the expression of melanosis-involved factors, and inhibiting melanosome transfer. The peptide of the present invention has excellent skin permeability due to the small size thereof. Excellent activity and stability of the foregoing peptide of the present invention can be very favorably applied to cosmetics.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: June 30, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung-Ji Lee, Jan Di Kim
  • Publication number: 20200197285
    Abstract: The present disclosure relates to a peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, 3, or 4, a pharmaceutical composition for preventing or treating skin disease including the peptide, a cosmetic composition for skin condition improvement including the peptide, a food composition for skin condition improvement including the peptide, a method of preventing or treating skin disease using the peptide, and a use of the peptide in preventing or treating skin disease or improving skin condition.
    Type: Application
    Filed: July 3, 2018
    Publication date: June 25, 2020
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung Ji LEE
  • Patent number: 10669312
    Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 2, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong-Ji Chung, Eun-Mi Kim, Eung-Ji Lee, Tae-Hoon Lee, A-Reum Han
  • Publication number: 20200148721
    Abstract: The present invention provides a peptide exhibiting melanogenesis promoting activity. A peptide according to the present invention increases the activity and expression of tyrosinase and the expression of factors involved in melanogenesis, thereby exhibiting an outstanding effect on melanogenesis. The peptide of the present invention can be used for the prevention, alleviation, and treatment of hypomelanosis. The outstanding activity and stability stated above allow the peptide of the present invention to be very favorably applied to medicines, quasi-medicines, and cosmetics.
    Type: Application
    Filed: February 21, 2018
    Publication date: May 14, 2020
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung-Ji LEE
  • Patent number: 10626145
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: April 21, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Patent number: 10568828
    Abstract: The present invention provides a peptide which shows a hair growth-promoting activity. The peptide of the present invention promotes the growth of follicular cells and increases the expression of a hair growth-related growth factor and hair growth-related factors, thereby showing an excellent effect in hair growth. The peptide of the present invention can be used for preventing and alleviating hair loss, promoting hair growth, and improving hair growth. In addition, the superior activity and stability of the peptide of the present invention allows the peptide to be very favorably applied to quasi drugs and cosmetics.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: February 25, 2020
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung-Ji Lee, Min Woong Kim
  • Publication number: 20200048323
    Abstract: The peptide of the present invention exhibits an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fats as well as an outstanding anti-diabetes effect by effectively lowering blood sugar levels. The peptide of the present invention downregulates the expression of the adipogenic markers PPAR?, ACC and/or aP2, upregulates the expression of the lipolytic factors pHSL, AMPK-?1. CGI-58 and/or ATGL, and reduces sizes of adipocyte and levels of cholesterol in blood. The excellent activity and stability of the peptide of the present invention may be very advantageously applied to drugs and quasi-drug products.
    Type: Application
    Filed: March 29, 2017
    Publication date: February 13, 2020
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji CHUNG, Eun Mi KIM
  • Patent number: 10526373
    Abstract: The present invention provides a peptide which shows a melanin generation-promoting activity. The peptide of the present invention increases the activity and expression of tyrosinase and increases the expression of factors related to melanin generation, thereby showing an excellent effect in melanin generation. The peptide of the present invention can be used for preventing, alleviating, and treating hypomelanosis. The above-mentioned superior activity and stability of the peptide of the present invention allows the peptide to be very favorably applied to medicines, quasi drugs, and cosmetics.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: January 7, 2020
    Assignee: Caregen Co., Ltd.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung-Ji Lee, Jan Di Kim
  • Patent number: 10508140
    Abstract: The present invention provides: a peptide which shows a hair growth-promoting activity and/or a melanin generation-promoting activity; a composition for preventing and/or alleviating hair loss, comprising the peptide as an effective ingredient; a composition for promoting hair growth, comprising the peptide as an effective ingredient; a use of the peptide for preventing and/or alleviating hair loss; a use of the peptide for promoting hair growth; a pharmaceutical composition for preventing and/or treating hypomelanosis, comprising the peptide as an effective ingredient; a cosmetic composition for preventing and/or treating hypomelanosis, comprising the peptide as an effective ingredient; and a use of the peptide for preventing and/or treating hypomelanosis.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: December 17, 2019
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung-Ji Lee
  • Publication number: 20190374599
    Abstract: The present invention relates to an antibacterial, anti-inflammatory, or antioxidant composition and, more specifically, to a compound having a structure in which salicylic acid is linked to a peptide via a covalent linkage, and to an antibacterial, anti-inflammatory, or antioxidant pharmaceutical or cosmetic composition containing the compound. The compound having a structure in which salicylic acid is linked to a peptide via a covalent linkage, of the present invention, has excellent physiological activity, such as antibacterial, anti-inflammatory, or antioxidant activity, as well as excellent characteristics, such as solubility in water, and thus the compound can be favorably used in various fields of food, drug, or cosmetics.
    Type: Application
    Filed: February 16, 2017
    Publication date: December 12, 2019
    Inventors: Yong Ji CHUNG, Eun Mi KIM
  • Patent number: 10487113
    Abstract: A peptide having activity to improve skin condition is described. The peptide exhibits a very excellent effect in improving skin condition by inhibiting MMP2 activity. A composition containing the peptide exhibits excellent biological activities, such as inhibiting collagen decomposition and melanosome migration, and thus can be used in wrinkle reduction, skin regeneration, skin elasticity improvement, anti-skin aging, wound regeneration, acne reduction, skin regeneration or skin whitening. The composition containing the peptide can be used as a pharmaceutical composition for preventing or treating MMP activity-related diseases and inflammation diseases.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 26, 2019
    Assignee: Caregen Co., Ltd.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Publication number: 20190328642
    Abstract: The present invention provides a peptide having skin-whitening activity. The peptide of the present invention exhibits an excellent skin whitening effect by inhibiting melanogenesis, inhibiting the activity of tyrosinase, inhibiting the expression of melanosis-involved factors, and inhibiting melanosome transfer. The peptide of the present invention has excellent skin permeability due to the small size thereof. Excellent activity and stability of the foregoing peptide of the present invention can be very favorably applied to cosmetics.
    Type: Application
    Filed: April 27, 2017
    Publication date: October 31, 2019
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung-Ji LEE, Jan Di KIM
  • Publication number: 20190270772
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Application
    Filed: March 20, 2019
    Publication date: September 5, 2019
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji CHUNG, Eun Mi KIM
  • Publication number: 20190270773
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Application
    Filed: March 20, 2019
    Publication date: September 5, 2019
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji CHUNG, Eun Mi KIM
  • Publication number: 20190270774
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Application
    Filed: March 20, 2019
    Publication date: September 5, 2019
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Patent number: 10351597
    Abstract: A peptide and a peptide complex of the present invention exhibit an anti-obesity effect by inhibiting fat accumulation and decomposing already accumulated fat, and exhibit an excellent effect with respect to diabetes by effectively reducing blood sugar. The peptide and the peptide complex of the present invention decrease the expression of PPAR?, ACC, and aP2, which are adipogenic markers, increase the expression of pHSL, AMPK-?1, CGI-58, and ATGL, which are lipolytic factors, and reduce the size of fat cells and blood cholesterol values. The peptide and the peptide complex of the present invention, which have excellent activity and safety, can be advantageously applied to drugs and quasi-drugs.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: July 16, 2019
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Patent number: 10351598
    Abstract: The present invention provides peptides with an anti-obesity and/or anti-diabetic activity consisting of an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, and optionally modified at their C- or N-terminal ends.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: July 16, 2019
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim