Abstract: New uses of an EGFR inhibitor are disclosed. Methods of treatment using the EGFR inhibitor are also disclosed.

Abstract: An LED structure includes a substrate, an LED chip disposed on the substrate, a wavelength conversion layer disposed above a light-emitting surface of the LED chip, and a cut-on optical filter disposed on a central region of the wavelength conversion layer.

Abstract: The present invention relates to a pharmaceutical composition comprising PD-1 antagonist and an EGFR Inhibitor. The present combination can be administered independently or separately, in a quantity which is jointly therapeutically effective for the treatment of cancer. The invention also provides the use of such a combination for the manufacture of a medicament; the use of such a combination as a medicine; a kit of part comprising such a combination; and a method of treatment of such a combination.

Abstract: Methods for the treatment of EGFR mutated cancer. For example, treatment of non-small cell lung cancer (NSCLC) with activating EGFR mutations (e.g., L858R and ex19del) the acquired or resistant “gatekeeper” T790M mutation, or any combination of these mutations.

Abstract: Systems, methods, and non-transitory computer-readable media can determine a meeting for which at least one resource has been reserved for a period of time, the meeting having been scheduled through a calendaring system. A determination is made whether the at least one resource is being used for the meeting at a time within the period of time for which the meeting was scheduled. The reservation for the at least one resource is canceled upon determining that the resource is not being used for the meeting, wherein the resource is then made available for reservation for a different meeting.

Abstract: An LED package structure with multiple color temperatures includes a substrate, a circuit layer disposed on the substrate, a plurality of first LED chips and a plurality of second LED chips disposed on the circuit layer, and a light conversion layer disposed on the substrate and the circuit layer. The light conversion layer has a spiral surface arranged away from the substrate. The light conversion layer includes a first light conversion portion and a second light conversion portion arranged around a lateral side of the first light conversion portion. The color temperature of the first light conversion portion is different from that of the second light conversion portion. The first LED chips are embedded in the first light conversion portion, and the second LED chips are embedded in the second light conversion portion. Thus, the LED package structure provided by the instant disclosure has good production efficiency.

Abstract: Systems, methods, and non-transitory computer-readable media can determine a meeting for which at least one resource has been reserved for a period of time, the meeting having been scheduled by a meeting organizer through by a calendaring system. A determination is made that a calendar event that references the meeting is not present in a calendar corresponding to the meeting organizer. The reservation for the at least one resource is canceled. The resource is available for reservation during the period of time for a different meeting.

Abstract: A switch includes an insulative housing, a fixed contact, a movable contact and an actuator. The insulative housing defining a receiving cavity enclosed by a number of peripheral walls each of which includes an inner surface exposed to the receiving cavity. The actuator includes a bottom portion slidably received in the receiving cavity, a bottom operator for deforming of the moveable contact and a button. The bottom portion includes a first side wall and a first rib protruding sidewardly therefrom. The first rib is slidable against a first inner surface of the peripheral walls while the first side wall is separated a distance from the first inner surface. As a result, contacting areas of the actuator and corresponding inner surface are greatly reduced, and soldering materials, such as flux, originally influencing movement of the actuator can be avoided.

Abstract: A switch includes an insulative housing, a pair of first and second contacts fixed in the insulative housing and a dome-shaped moveable contact. The insulative housing includes a receiving space and a first peripheral wall located outside of the receiving space. The first and the second contacts include first and second contacting sections, respectively. The first and the second contacting sections are separated a distance from each other and exposed in the receiving space. The dome-shaped moveable contact is mounted in the receiving space under condition that the moveable contact is constantly in contact with the second contacting section while the moveable contact is alternatively driven to engage with the first contacting section so as to establish electrical connection between the first contact and the second contact. The first peripheral wall defines a sinuated air-passageway communicating the receiving space to outside.

Abstract: A switch includes an insulative housing, a pair of first and second contacts fixed in the insulative housing and a dome-shaped moveable contact. The insulative housing includes a receiving space and a first peripheral wall located outside of the receiving space. The first and the second contacts include first and second contacting sections, respectively. The first and the second contacting sections are separated a distance from each other and exposed in the receiving space. The dome-shaped moveable contact is mounted in the receiving space under condition that the moveable contact is constantly in contact with the second contacting section while the moveable contact is alternatively driven to engage with the first contacting section so as to establish electrical connection between the first contact and the second contact. The first peripheral wall defines a sinuated air-passageway communicating the receiving space to outside.

Abstract: A tilt switch (100) includes an insulative housing (2), a number of contacts (3) retained in the insulative housing, a conductive rotary ball (4), and a top cover (5) attached to the insulative housing. The insulative housing includes a bottom wall (21) and a number of vertical walls (22) cooperatively defining a receiving space (20). The bottom wall defines a plurality of passageways (211) and a plurality of cutouts (212). The cutouts extend along an up-and-down direction and communicates between the passageways and exterior. Each cutout has a smaller top end and a larger bottom end for preventing soldering material from entering into the receiving space. The contacts are retained in the passageways of the insulative housing. The rotary ball is received in the receiving space and connects with selected ones for establishing different states.

Abstract: A switch includes an insulative housing, a fixed contact, a movable contact and an actuator. The insulative housing defining a receiving cavity enclosed by a number of peripheral walls each of which includes an inner surface exposed to the receiving cavity. The actuator includes a bottom portion slidably received in the receiving cavity, a bottom operator for deforming of the moveable contact and a button. The bottom portion includes a first side wall and a first rib protruding sidewardly therefrom. The first rib is slidable against a first inner surface of the peripheral walls while the first side wall is separated a distance from the first inner surface. As a result, contacting areas of the actuator and corresponding inner surface are greatly reduced, and soldering materials, such as flux, originally influencing movement of the actuator can be avoided.

Abstract: A push-push switch includes a housing having a space, a plurality of stationary terminals received in the housing, a button assembled to the housing, a movable terminal assembled to the button, and a spring member located between the housing and the button. The space has a first post defining a protrusion thereon. The stationary terminal defines a contacting portion extending onto a surface of the first post and a soldering portion extending out of the housing. The movable terminal further defines a downwardly-extending contact arm and a downwardly-extending felt-generated spring arm extending from a planar base portion thereof while at different positions. The contact arm is established electrically connection with the contacting portion of the stationary terminal when the button is depressed, and the felt-generated spring arm is engaged with the protrusion of the first post in the meantime.

Abstract: A card connector, comprising: an insulative housing having a base, first and second sidewalls extending upwardly from two opposite sides of the base, a card receiving space defined by the base and the first and second sidewalls; a plurality of contacts held within the housing, the contacts having contact sections extending beyond the base; a pair of detecting switches including a stable switch and a movable switch both around a region located backwardly of the first sidewall; and a flange-like plane portion on said first sidewall and essentially vertical to said first sidewall, a front guiding entrance defined by said flange-like plane portion, the first sidewall, the second sidewall and the base.

Abstract: A push-push switch comprises a housing having a space, a plurality of stationary terminals received in the housing, a button assembled to the housing, a movable terminal assembled to the button, and a spring member located between the button and the button. The space has a first post defining a protrusion thereon. The stationary terminal defines a contacting portion extending onto a surface of the first post and a soldering portion extending out of the housing. The button defines a second post extending into the first post when the push-push switch is completely assembled. The movable terminal defines a base portion having a mounting hole around the second post for assembling the movable terminal on the button. The movable terminal further defines a downwardly-extending contact arm and a downwardly-extending felt-generated spring arm.

Abstract: A card connector, comprising: an insulative housing having a base, first and second sidewalls extending upwardly from two opposite sides of the base, a card receiving space defined by the base and the first and second sidewalls; a plurality of contacts held within the housing, the contacts having contact sections extending beyond the base; a pair of detecting switches including a stable switch and a movable switch both around a region located backwardly of the first sidewall; and a flange-like plane portion on said first sidewall and essentially vertical to said first sidewall, a front guiding entrance defined by said flange-like plane portion, the first sidewall, the second sidewall and the base.