Abstract: Disclosed are combination therapies comprising administration of a CD73 inhibitor and an adenosine A2A or A2B receptor inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies and A2A/A2B inhibitors are also disclosed.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: Aspects of the disclosure relate to a method of operating a scheduled entity for wireless communication. In some aspects, the scheduled entity detects a fluctuation in a beam strength of at least one transmit beam from a scheduling entity. The scheduled entity transmits a first message to the scheduling entity, the first message indicating at least the fluctuation in the beam strength of the at least one transmit beam from the scheduling entity.

Abstract: The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

Abstract: The present disclosure provides a method and device for configuring a channel state information reference signal (CSI-RS), and a method and device for parsing CSI-RS. The configuration method includes: configuring configuration information of the CSI-RS by a base station; generating a signaling carrying the configuration information of the CSI-RS by the base station; and transmitting the signaling by the base station. The configuration information includes at least one of: a number of CSI-RS ports, a number K of components of a pilot resource pattern, a number N of ports of the components of the pilot resource pattern, and a CSI-RS port-numbering mode, where the CSI-RS port-numbering mode is selected from M candidate port-numbering modes, and M, K, and N are positive integers.

Abstract: The present invention belongs to the technical field of metal materials for additive manufacturing, and relates to a Mn—Cu-based damping alloy powder for use in a selective laser melting (SLM) process and a preparation method thereof. The powder has chemical components in percent by weight as follows: C: ?0.15%, Ni: 4.9-5.2%, Si: ?0.15%, Fe: 1.8-5.0%, Cu: 20-23%, P: ?0.03%, S: ?0.06%, and the balance being Mn and inevitable impurities. The preparation method includes: preparation of master alloy, powdering by vacuum induction melting gas atomization (VIGA), mechanical vibrating and air classification screening under protection of an inert gas and collecting. Compared with the prior art, the powder of the present invention has a high sphericity, a high apparent density, a small angle of repose, a desired fluidity and a relatively high yield of fine powders having a size of 15-53 ?m.

Abstract: Systems and methods for reclaiming and remagnetizing permanent magnet motors such as may be used in electric submersible pumps. In one embodiment, a method includes removing a permanent magnet rotor assembly from a motor and heating the rotor to burn off the residual oil and evaporate water in between laminations of the rotor and on the rotor surface. The rotor should be heated to a temperature that is above a flashpoint of oil on the rotor and below a Curie temperature of a material of a set of permanent magnets in the rotor (e.g., at least 600° F. for at least 12 hours). The heating may partially or fully demagnetize the permanent magnets in the rotor. The exposed surfaces of the rotor are then cleaned and the permanent magnets in the rotor are remagnetized using a specialized magnetizing fixture.

Abstract: One exemplary embodiment provides a dual-speed dual-core enhanced drilling equipment which comprises an outer cylinder, a downhole power device, a large cutting head and a small cutting head, wherein the large cutting head is provided with a first centerline, a through hole arranged along the first centerline and a first diameter; the outer cylinder is sleeved outside the downhole power device and forms an annular space, and the outer cylinder directly or indirectly connects the upper drill string with the large cutting head so that the large cutting head and the downhole power device can rotate together with the upper drill string; the downhole power device is provided with a power generation section capable of generating power and a rotation output section which penetrates through the through hole to be connected with the small cutting head and provides independent power for the small cutting head, so that the small cutting head revolves around the first centerline under the driving of the upper drill strin

Abstract: Systems and methods for electric motor, where the stator core has one or more stator core sections, each of which is a single-piece unit formed of soft magnetic composite (SMC) material, and where the stator core sections are positioned end-to-end with seals at each end to form a plurality of stator slots, where each of the stator slots extends through each of the stator core sections and is in fluid communication with the others to form a sealed stator chamber. The sealed stator chamber may have an expansion chamber to allow expansion and contraction of dielectric fluid in the stator chamber while maintaining separation of the dielectric oil from lubricating oil which is within the motor but external to the stator chamber. The sealed stator chamber can prevent well fluids that leak into the motor from reaching the stator windings and degrading their insulation.

Abstract: Systems and methods for electric motor, where the stator core has one or more stator core sections, each of which is a single-piece unit formed of soft magnetic composite (SMC) material, and where the stator core sections are positioned end-to-end with seals at each end to form a plurality of stator slots, where each of the stator slots extends through each of the stator core sections and is in fluid communication with the others to form a sealed stator chamber. The sealed stator chamber may have an expansion chamber to allow expansion and contraction of dielectric fluid in the stator chamber while maintaining separation of the dielectric oil from lubricating oil which is within the motor but external to the stator chamber. The sealed stator chamber can prevent well fluids that leak into the motor from reaching the stator windings and degrading their insulation.

Abstract: Provided is signaling transmitting and receiving methods, device, network-side device, terminal and storage medium. The signaling transmitting method includes: determining a first parameter set and/or a second parameter set for N resource groups; and transmitting an indication signaling, the indication signaling carries indication information for indicating the first parameter set and/or the second parameter set. The signaling receiving method includes: receiving an indication signaling transmitted by a network-side device. The indication signaling carries indication information for indicating a first parameter set and/or a second parameter set determined by the network-side device for N resource groups. The first parameter set is a Physical Downlink Shared Channel Resource Element (PDSCH RE) mapping set. The second parameter set is a Quasi-Co-Location (QCL) parameter set. N is a positive integer greater than 1.

Abstract: Provided are a channel state processing method and apparatus, a system, a terminal, a base station, and a storage medium. The method includes: receiving a configuration parameter sent by the base station; determining channel state information according to the configuration parameter; vectorizing the channel state information, and determining a reference vector coefficient for the channel state information; determining, according to the reference vector coefficient, a vector coefficient variation of the vectorized channel state information; and reporting the vector coefficient variation and the reference vector coefficient separately.

Abstract: A convertible force latching system includes two complementary connector bodies. Each connector body has a first mating face under which two series of magnets oriented alternating directions. A moving portion of the latching system allows the connector bodies and the magnets within to alter their alignment by the interaction of a user along a predetermined motion path. In a first arrangement, the series of magnets are aligned with such that the magnets of one connector body are attracted to the magnets of the other connector body. When the user actuation shifts the moving portion, the second arrangement positions the series of magnets such that they are aligned such that the magnets of one connector body are repelled to the magnets of the other connector body.

Abstract: Provided are a method and apparatus for transmitting and receiving channel state information, a communication node, and a storage medium. A CSI matrix H is decomposed to obtain a vector group, where the vector group comprises at least two vector matrices, element information of at least one vector matrix in the vector group is quantized, and the quantized element information is transmitted.

Abstract: A data receiving method includes: receiving first downlink control information; receiving first data in a subframe subsequent to a subframe corresponding to the first downlink control information; if second downlink control information is not received, storing the first data located between a current subframe and the subframe corresponding to the first downlink control information; if the second downlink control information is received, acquiring demodulation auxiliary information; receiving data overlapping in time domain and frequency domain in a subframe subsequent to a subframe corresponding to the second downlink control information, the overlapping data comprising second data and third data; demodulating the stored first data according to the demodulation auxiliary information to obtain demodulated data corresponding to second user equipment; determining the third data in the overlapping data according to the demodulated data corresponding to the second user equipment; and acquiring the second data from

Abstract: A switching power converter is provided that communicates with a mobile device to receive a value of a load detection current. The switching power converter adjusts the cycling of a power switch until a constant current mode of operation is entered with a known output current driving the mobile device. The switching power converter subtracts the load current from the output current to measure a soft-short circuit current.

Abstract: Provided is an underwater repair system for a cavity region of a concrete panel rock-fill dam panel, including a moving platform, a work cabin, a pressure drainage apparatus, a traction apparatus, and a positioning apparatus; the traction apparatus controlling the movement of the moving platform on the surface of a dam concrete panel; the positioning apparatus transmits a detection position, the work cabin is a pressure cabin, the work cabin being connected to the pressure drainage apparatus, and a drill apparatus and grouting apparatus being arranged in the work cabin; the moving platform moves into the cavity region, and the pressure drainage apparatus starts up to drain the water in the work cabin, a partially closed waterless space being formed inside the work cabin, the drill apparatus drilling the concrete panel at the upper end of the cavity region and the grouting apparatus subsequently implementing grouting to complete the repair.

Abstract: A motor includes a stator, a rotor rotatable relative to the stator, a support member, and a circuit assembly. The circuit assembly includes a plurality of electronic components. The rotor is rotatably mounted to the support member. The stator is received in the rotor. The stator is fixed to the support member, and the support member is at least partially received in an inner side of the stator. A portion of the support member received in the inner side of the stator defines a receiving space, and at least part of the electronic components of the circuit assembly is received in the receiving space of the support member. The support member is partially received in the inner side of the stator, and the circuit assembly is at least partially received in the support member, which makes the motor have a relatively smaller axial size.

Abstract: The present disclosure provides HKMG transistor structures and fabrication methods thereof. An exemplary method includes providing a base substrate having a first region and a second region; forming a dielectric layer having a first opening in the first region and a second opening in the second region over; forming a gate dielectric layer on a side surface of the first opening and a portion of the base substrate in the first opening and on a side surface of the second opening and a portion of the base substrate in the second opening; filling a sacrificial layer in the first opening; forming a second work function layer in the second opening and a second gate electrode layer on the second work function layer; removing the sacrificial layer; and forming a first work function layer in the first opening and a first gate electrode layer on the first work function layer.