Abstract: Four linker molecules were designed to attach peptides to various aqueous-compatible polymer solid phases for Solid Phase Peptide Synthesis (SPPS) in aqueous solutions. Linker molecule A is utilized to attach peptides to an anionic exchange resin in an aqueous solution, and linker molecule B is employed for binding peptides to a cationic exchange resin in an aqueous solution. Both anionic and cationic exchange resins are reusable once the peptide synthesis process is completed. Linker molecule C is utilized to connect the peptide to an amino resin, whereas linker molecule D is employed to bind the peptide to a carboxyl resin. Additionally, linker molecule C can serve as a precursor to linker molecule A, and linker molecule D can function as a precursor to linker molecule B. In all four linker molecules, the amino acid (AA) is linked to solid phases through a benzylic ester bond, which can be cleaved under acidic conditions to release the peptide chain at the end of synthesis.

Abstract: A laser cleaning method for multiple tabs includes: performing a parallelism correction of each galvanometer to be spliced relative to a processing platform; splicing multiple galvanometers into a galvanometer array, performing parallelism calibration between adjacent galvanometers in the galvanometer array; performing a distortion correction on a single frame produced by each galvanometer; splicing multiple single frames corresponding to multiple galvanometers into an entire frame corresponding to the galvanometer array; normalizing a single frame coordinate system corresponding to each single frame into an entire frame coordinate system corresponding to the entire frame; obtaining offset information of a material strip edge of a material strip passing through a laser cleaning device relative to a material strip travel direction, and performing offset compensation on the galvanometer array based on the offset information; and performing laser cleaning simultaneously on multiple tabs on a pole piece by the ga

Abstract: Provided are antibodies or antigen-binding fragments that bind to human CD26, bispecific T-cell engagers including the sequence of such antibodies or antigen-binding fragments, and applications of such antibodies or antigen-binding fragments in the preparation of drugs for the treatment of tumors with high expression of CD26.

Abstract: CD45 is used as a biomarker in screening the effectiveness of a CD26 antibody or derivative thereof in treating tumors in a test subject. Specifically, when CD45 is not expressed or has low expression, determining that the treatment of the test subject who has received a CD26 antibody or a derivative thereof is effective or has a high probability of being effective; and when CD45 expression is high or relatively high, determining that the treatment of the test subject who has received a CD26 antibody or a derivative thereof is ineffective or has a high probability of being ineffective. It has been found that CD26 acts as a new mechanism for treatment effectiveness and precision of novel tumor immunotherapy targets.

Abstract: Provided is a method for realizing the controlled release and sustained release of the activity of bioactive molecules and use for drugs. Provided is a PEG modifier of a specific structure. The PEG modifier can be widely applied to the controlled release and sustained release of the activity of various bioactive molecules. A conjugate is formed by reacting the PEG modifier of the specific type and structure with IL-2. In a certain in vitro condition or in vivo physiological condition, PEG gradually falls off from the conjugate and the activity of IL-2 is gradually released, so that a certain effective plasma concentration where bioactive molecules are relatively stable can be maintained, and thus the in vivo or in vitro sustained release and controlled release of the activity of the drug are realized.

Abstract: Disclosed is a method for scheduling cars at a narrow curve based on a parking space for temporary avoidance. The method includes: fusing car data obtained by laser radar and millimeter wave radar, so as to predict car states and driving trajectories of meeting cars; computing an expected meeting point of the cars through prediction of the driving trajectories of the cars; and executing, on the basis of the expected meeting point, different car avoidance strategies according to road conditions and a number of parking spaces for temporary avoidance, so as to implement car avoidance and scheduling of car meeting at the narrow curve.

Abstract: Provided is use of kinin or derivative thereof, in particular long-acting kinin or derivative thereof, in treating vascular cognitive impairment (VCI), post-stroke cognitive impairment (PSCI), or cerebral small vessel disease (CSVD). VCI and PSCI are generally associated with cognitive function impairment and psychoactive behavioral symptom. Drugs for treating cognitive impairment in VCI and PSCI include cholinesterase inhibitors, non-competitive N-methyl-D-asparagine receptor antagonists, and drugs for treating psychoactive behavioral symptom include antidepressants. Patients with chronic CSVD may have symptoms such as cognitive disorder, movement disorder, emotional disorder, defecation disorder and other symptoms. Cholinesterase inhibitors and non-competitive N-methyl-D-asparagine receptor antagonists can be used for cognitive disorder, and antidepressants are generally used for depression.

Abstract: A recombinant type I allergen of Artemisia annua pollen (Art a 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art a 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art a 1 is equivalent to that of a native protein, and the Art a 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

Abstract: Method for acquiring seismic data is described. The method includes obtaining undersampled seismic data acquired from a non-uniform sampling grid. Attenuating multiples from the undersampled seismic data.

Abstract: A first playback device can include a wireless network interface, an audio input interface, one or more processors, and data storage. The data storage stores instructions that, when executed by the processors, cause the first playback device to determine a first radio frequency (RF) energy level associated with RF signal communications from a second playback device to the first playback device. The first playback device modifies a threshold RF energy level for holding off transmissions by the first playback device based on the first RF energy level. The first playback device receives multi-channel audio content via the audio input interface and detects an ambient RF energy level.

Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.

Abstract: A phase shifter, a phase shifter array, an antenna array and an electronic device are provided and belong to the field of communication technology. The phase shifter includes: first and second dielectric substrates opposite to each other, a first transmission line and a second transmission line on a side of the first dielectric substrate close to the second dielectric substrate, patch electrodes on a side of the second dielectric substrate close to the first dielectric substrate, and a tunable dielectric layer between a layer where the transmission lines are located and a layer where the patch electrodes are located; wherein orthographic projections of two ends of each patch electrode on the first dielectric substrate overlap with orthographic projections of the first and second transmission lines on the first dielectric substrate, respectively; and at least two of the plurality of patch electrodes are connected to different first bias voltage lines.

Abstract: A recombinant type I allergen of Artemisia vulgaris pollen (Art v 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art v 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art v 1 is equivalent to that of a native protein, and the Art v 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

Abstract: Provided are a safety control method and apparatus for an electric drive system, a device, and a storage medium. The safety control method for an electric drive system includes: acquiring a current operating mode of an electric drive system, the current working mode includes a boost charging mode and a power output mode; configuring a safety state corresponding to the current operating mode for the electric drive system; and when a fault occurs, controlling the electric drive system to enter the safety state, in the safety state, the output torque of the electric drive system is caused to be less than or equal to a preset torque value corresponding to the current operating mode.

Abstract: The present invention discloses a vibration suppression system and method for a star simulation system using laser interference detection. The system includes a laser light source, a first beam splitter, a collimator set, a second beam splitter, a mirror, a detection convergent mirror assembly, a CCD detector, a computer control system, a jitter compensating mirror and a flat splitter; the optical path of the whole system includes a reference optical path and a detection compensating signal optical path. The reference optical path and the detection compensating signal optical path converge at the same time on the CCD detector to constitute a vibration detection interference optical path, and the computer control system performs feedback compensation according to the interferogram intensity change formed by the vibration detection interference optical path. Both the CCD detector and the jitter compensating mirror are connected to the computer control system.

Abstract: A system for purifying helium gas, a method, and an application. The system includes a first gas-liquid separation device, a primary helium extraction tower, a second gas-liquid separation device, a secondary helium extraction tower, and a nitrogen removal tower, which are in sequential communication. The first gas-liquid separation device performs first treatment to convert helium-containing natural gas into a first gas and first liquid phases; the primary helium extraction tower performs first distillation on the first gas and first liquid phases to obtain a second gas and second liquid phases; the second gas-liquid separation device performs second treatment to convert the second gas phase to a third gas and third liquid phase; the secondary helium extraction tower performs second distillation on the third gas and third liquid phases to obtain crude helium and a fourth liquid phase form which nitrogen is removed by the nitrogen removal tower.

Abstract: A system for enhancing traveltime information in a seismic dataset and determining a velocity model. The system includes a first initial velocity model, a forward modelling procedure, a machine-learned model, a drilling system with a wellbore planning system, and a computer. The computer is configured to: receive a non-synthetic seismic data set for a subsurface region of interest; perturb the first initial velocity model forming a first plurality of velocity models; simulate, with the forward modelling procedure, a first plurality of seismic data sets; form a first plurality of transformed seismic data sets with enhanced traveltime; train the machine-learned model using the first plurality of velocity models and the first plurality of transformed seismic data sets; transform the non-synthetic seismic data set to a non-synthetic transformed seismic data set; and process the non-synthetic seismic data set with the trained machine-learned model to predict a velocity model for the subsurface region.

Abstract: A backlight module includes a back plate, a plastic frame disposed on one side of the back plate and connected with the back plate, a light source assembly located on an inner side of the plastic frame, and a reflective sheet, a light guide plate, and an optical membrane group sequentially stacked and located on the inner side of the plastic frame; the light source assembly includes a circuit board and a light source disposed on a first side surface of the circuit board, and the light source is located at a first side edge of the light guide plate; the light guide plate includes a first surface facing the reflective sheet and a second surface facing away from the reflective sheet; a first rectangular annular step and a second rectangular annular step are provided on an end face of the plastic frame facing the back plate.

Abstract: A frame sealing adhesive of the liquid-crystal phase shifter is disposed between two transparent substrates, the frame sealing adhesive encloses a first cavity, a first part of the metal-trace layer is located inside the first cavity, and a second part of the metal-trace layer is located outside the first cavity. The second part is disposed on first surfaces or second surfaces of the two transparent substrates. If the second part is disposed on the first surfaces of the two transparent substrates, metal cushion layers are provided between the frame sealing adhesive and the first surfaces of the two transparent substrates. If the second part is disposed on the second surfaces of the two transparent substrates, the first part and the second part are electrically connected by metal via holes provided in the transparent substrates, and the frame sealing adhesive contacts the first surfaces of the two transparent substrates.