Patents by Inventor Yong Mao

Yong Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210121855
    Abstract: Disclosed are a nitrogen-doped hierarchical-porous carbon-loaded nano-Pd catalyst and a preparation method thereof. The preparation method includes preparing nitrogen-doped hierarchical-porous carbon, mixing the nitrogen-doped hierarchical-porous carbon with water, adjusting a pH value of the mixed solution to be alkaline, mixing the mixed solution with a Pd metal precursor aqueous solution, and then adding a reducing agent to obtain the nitrogen-doped hierarchical-porous carbon-loaded nano-Pd catalyst after reduction. The prepared nitrogen-doped hierarchical-porous carbon-loaded nano-Pd catalyst includes a nitrogen-doped porous carbon material carrier with hierarchical pores and Pd metal nanoparticles loaded in the hierarchical pores of the carrier. The Pd metal nanoparticles have a size of 2˜14 nm and a regular polyhedron shape.
    Type: Application
    Filed: October 19, 2020
    Publication date: April 29, 2021
    Applicant: ZHEJIANG UNIVERSITY
    Inventors: Yong WANG, Shanjun MAO, Zhe WANG
  • Patent number: 10964410
    Abstract: The present disclosure pertains to a system, a method of using such a system, and a non-transitory computer-readable medium containing instructions to such a system for generating annotated gene fusion data from processing both a patient's DNA and RNA sequence information thereby filtering out weak candidate gene fusions. Thus the annotated gene fusion data contains clinically relevant information and accurate gene fusion detections (low false-positives) for use in clinical and/or R&D settings. The system, method and computer-readable medium allows a user to generate gene fusion data by detecting breakpoints from a patient's DNA-SEQ and RNA-SEQ, creating candidate breakpoint data by combining matching breakpoints from the DNA-SEQ and RNA-SEQ breakpoint data, determining confidence levels of the candidate breakpoint, identifying corresponding gene fusions, and annotating clinically relevant information about the gene fusions.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: March 30, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Yong Mao, Nevenka Dimitrova, Kostyantyn Volyanskyy
  • Patent number: 10730851
    Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: August 4, 2020
    Assignee: Yunnan Institute of Materia Medica
    Inventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
  • Publication number: 20200234801
    Abstract: A method (100) for recruiting a patient for a clinical trial, comprising: receiving (110) a dataset comprising information about one or more clinical trials each including patient eligibility criteria; extracting (120) the patient eligibility criteria from each of the clinical trials; converting (130) the patient eligibility criteria to a standardized patient eligibility criterion using a structured clinical trial mark-up language; storing (140) the patient eligibility criterion in a database (862), each of the criterion associated with one or more clinical trials; receiving (150) patient-specific data values about a patient; querying (160) the clinical trial eligibility criteria database using the patient-specific data values to identify eligibility criterion satisfied by the patient-specific data value; identifying (170) a clinical trial associated with the one or more standardized patient eligibility criterion satisfied by a received patient-specific data value; and providing (180) a report of the identifi
    Type: Application
    Filed: October 5, 2018
    Publication date: July 23, 2020
    Inventors: Yong Mao, Woei-Jye Yee, Alexander Ryan Mankovich, Qingxin Wu, Kostyantyn Volyanskyy, Nevenka Dimitrova
  • Publication number: 20200024658
    Abstract: A method and a system for interpreting data between two quantitative genomic datasets are described, wherein datasets are associated with the same disease or condition, for example, samples from the same patient obtained on different genomic platforms with varying data acquisition parameters. The data samples in each of the first and second datasets are rank ordered and the relative distances among the data samples are determined. The value ranks and relative distances are then used to correlate to data samples in the first and second quantitative genomic datasets, with the output provided to a user, such as a clinician or a patient.
    Type: Application
    Filed: March 28, 2018
    Publication date: January 23, 2020
    Inventors: Kostyantyn Volyanskyy, Nevenka Dimitrova, Yong Mao
  • Publication number: 20200020423
    Abstract: A system and method for providing a prioritized list of clinical trials that are relevant to a patient suffering from an illness or disease, such as cancer, are disclosed. Specifically, a method for conducting an automated, real time clinical trial search and a prioritization analysis is described. The method comprises the steps of conducting an automated full-text clinical trial search based on structuralization of clinical trial eligibility data and knowledge-based inference, initiating a query from the patient's side, and providing a prioritized list of all accessible clinical trials fulfilling a particular query. The system provides better sensitivity, precision and negative predictive value than the current most known clinical trial matching tool: clinicaltrials.gov.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 16, 2020
    Inventors: Qingxin Wu, Alexander Ryan Mankovich, Abhishek Talluli, Kostyantyn Volyanskyy, Nevenka Dimitrova, Yong Mao, Charles Yee
  • Publication number: 20190270720
    Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.
    Type: Application
    Filed: November 21, 2016
    Publication date: September 5, 2019
    Applicant: Yunnan Institute of Materia Medica
    Inventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
  • Publication number: 20190189248
    Abstract: Methods, systems and apparatus for detecting subpopulations of constituents of at least one biological organism are disclosed. In accordance with exemplary embodiments, cluster partitions of biological data samples compiled from constituents of at least one biological organism are evaluated (114) by computing inconsistency scores for the partitions based on an inconsistency measure. In addition, for at least one of the plurality of partitions, a non-zero value is allocated to the inconsistency measure of at least one cluster that has only one biological data sample. Further, the subpopulations are identified by selecting the partition of having the minimum inconsistency score as the subpopulations.
    Type: Application
    Filed: May 11, 2017
    Publication date: June 20, 2019
    Applicant: Koninklijke Philips N.V.
    Inventors: Konstantin VOLYANSKYY, Nevenka DIMITROVA, Yong MAO
  • Publication number: 20190163918
    Abstract: A method for assessing risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising: (i) generating an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles; (ii) generating an inquirer database comprising allele request information about a plurality of inquirers; (iii) receiving a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer; (iv) updating the request frequency information based on the received request; (v) updating the allele request information for the requesting inquirer; (vi) calculating an allele risk score; (vii) calculating an inquirer risk score; and (viii) assessing, based on the allele risk score and the inquirer risk score, a risk associated with the received request.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 30, 2019
    Inventors: Jin Qu, Fubiao Xia, Yong Mao, Alexander Ryan Mankovich, Raymond J. Krasinski
  • Publication number: 20180341746
    Abstract: The present disclosure pertains to a system, a method of using such a system, and a non-transitory computer-readable medium containing instructions to such a system for generating annotated gene fusion data from processing both a patient's DNA and RNA sequence information thereby filtering out weak candidate gene fusions. Thus the annotated gene fusion data contains clinically relevant information and accurate gene fusion detections (low false-positives) for use in clinical and/or R&D settings. The system, method and computer-readable medium allows a user to generate gene fusion data by detecting breakpoints from a patient's DNA-SEQ and RNA-SEQ, creating candidate breakpoint data by combining matching breakpoints from the DNA-SEQ and RNA-SEQ breakpoint data, determining confidence levels of the candidate breakpoint, identifying corresponding gene fusions, and annotating clinically relevant information about the gene fusions.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 29, 2018
    Inventors: Yong Mao, Nevenka Dimitrova, Kostyantyn Volyanskyy
  • Publication number: 20180330805
    Abstract: A data-driven integrative visualization system and a method for visualization and exploration of the multi-modal features of a cohort of samples, is disclosed Specifically, a method for providing an interactive computation and visualization front-end of a genomics platform for presenting the complex multiparametric and high dimensional, multi-omic data of a patient with respect to a cohort of samples, that assists the user in understanding the similarities and differences across individual or groups of samples, identify correlation among different features and improve treatment planning and long term patient care, is described. The method may include obtaining and inputting multi-omic data of a patient and/or cohorts, identifying multi-modal feature variations and their relationships, and displaying this information in an interactive circular format on a GUI, from which the user can access further information.
    Type: Application
    Filed: May 8, 2018
    Publication date: November 15, 2018
    Inventors: Yee Him Cheung, Yong Mao, Nevenka Dimitrova, Nilanjana Banerjee, Johanna Maria de Bont, Jozef Hieronymus Maria Raijmakers, Kostyantyn Volyanskyy
  • Publication number: 20180301205
    Abstract: A patient-trial matching system (100) includes a structuralizer (102) configured to convert input non-structured patient health data and input non-structured clinical trial eligibility criteria into structured patient health data and structured clinical trial eligibility criteria by organizing a content of the non-structured data as known data elements. The patient-trial matching system further includes a semantic matcher (122) configured to match the structured patient health data and the structured clinical trial eligibility criteria based on user input matching criteria and outputs matched results. The patient-trial matching system further includes a ranking engine (126) configured to rank the matched results using ranking criteria (128), which include ranking patients matched to a clinical trial of interest in response to matching to find a group of trial patients and ranking clinical trials matched to a particular patient in response to matching to find a clinical trial.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 18, 2018
    Inventor: Yong Mao
  • Patent number: 9220259
    Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: December 29, 2015
    Assignee: LifeCell Corporation
    Inventors: Rick T. Owens, Mike Liu, Yong Mao
  • Publication number: 20140296623
    Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
    Type: Application
    Filed: June 12, 2014
    Publication date: October 2, 2014
    Inventors: Rick T. Owens, Wendell Sun, Mike Liu, Yong Mao
  • Patent number: 8784499
    Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: July 22, 2014
    Assignee: LifeCell Corporation
    Inventors: Rick Owens, Wendell Sun, Mike Liu, Yong Mao
  • Patent number: 8619220
    Abstract: A manufacturing method of a color filter including following steps is provided. First, a partition is formed on a substrate to form a plurality of pixel regions on the substrate. Next, a color pigment is provided along a continuous pigment-providing route, so as to form the color pigment on a sequence of pixel regions among the plurality of pixel regions and the partition. The method mentioned above can prevent the unfilled phenomenon of the pigment around the corners of the pixel region. Besides, a liquid crystal display panel having the color filter is also provided.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: December 31, 2013
    Assignee: Au Optronics Corporation
    Inventors: Wei-Ya Wang, Shu-Chin Lee, Wen-Lung Chen, Fu-Chuan Tsai, Yung-Lung Lin, Yong-Mao Lin, Chun-Chieh Tsao
  • Publication number: 20130253212
    Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
    Type: Application
    Filed: May 21, 2013
    Publication date: September 26, 2013
    Applicant: LIFECELL CORPORATION
    Inventors: Rick T. Owens, Mike Liu, Yong Mao
  • Patent number: 8486616
    Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 16, 2013
    Assignee: Lifecell Corporation
    Inventors: Rick T. Owens, Mike Liu, Yong Mao
  • Patent number: 8343717
    Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: January 1, 2013
    Assignee: Lifecell Corporation
    Inventors: Rick T. Owens, Mike Liu, Yong Mao
  • Publication number: 20120301354
    Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
    Type: Application
    Filed: August 7, 2012
    Publication date: November 29, 2012
    Inventors: Rick T. Owens, Mike Liu, Yong Mao