Abstract: A method of promoting nerve regeneration in a subject that includes administering to the subject a therapeutically effective amount of a composition that includes at least one therapeutically-active extract fraction of Centella asiatica. One example of making the extract fraction of Centella asiatica involves extracting Centella asiatica plant material resulting in an extract residue and successively fractionating the Centella asiatica extract residue with at least two eluants of increasing polarity.

Abstract: Disclosed herein are several methods for promoting nerve regeneration. The methods include administering at least one tyrphostin, or a pharmaceutically acceptable salt thereof. In one non-limiting example, the tyrphostin is tyrphostin A9. These methods can be used to promote nerve growth in the central or peripheral nervous system. The methods are of use in treating neurodegenerative diseases, such as Parkinson's disease, or in treating the transaction of a partial or complete transaction of a nerve in the peripheral or central nervous system.

Abstract: A method of promoting nerve regeneration in a subject that includes administering to the subject a therapeutically effective amount of a composition that includes at least one therapeutically-active extract fraction of Centella asiatica. One example of making the extract fraction of Centella asiatica involves extracting Centella asiatica plant material resulting in an extract residue and successively fractionating the Centella asiatica extract residue with at least two eluants of increasing polarity.