Patents by Inventor Yong-Rui Zou

Yong-Rui Zou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted replacement of a gene without endogenous and selectable residual sequences
    Publication number: 20030167489
    Abstract: Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with human genes, either through conventional gene targeting, or by use of the bacteriophage-derived Cre-loxP recombination system. The transgenic animals undergo antibody affinity maturation, and a class switch from the native immunoglobulin to the humanized form.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 4, 2003
    Inventors: Klaus Rajewsky, Yong-Rui Zou
  • Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice
    Patent number: 6570061
    Abstract: Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with human genes, either through conventional gene targeting, or by use of the bacteriophage-derived Cre-loxP recombination system. The transgenic animals undergo antibody affinity maturation, and a class switch from the native immunoglobulin to the humanized form.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: May 27, 2003
    Inventors: Klaus Rajewsky, Yong-Rui Zou