Abstract: A chemical mechanical polishing method is provided. A chemical mechanical polishing method comprising providing a polishing pad, supplying a first purging compound having a first temperature onto the polishing pad, supplying a first slurry having a third temperature onto the polishing pad supplied with the first purging compound, supplying a second purging compound having a second temperature lower than the first temperature onto the polishing pad, and supplying a second slurry having a fourth temperature lower than the third temperature onto the polishing pad supplied with the second purging compound.

Abstract: A cooling structure includes a housing having a cooling channel defined therein through which a coolant flows and includes a sealing cap fitted to a hole of the housing to seal the hole. The sealing cap includes a blocking member configured to be in contact with an internal surface of the housing. The cooling structure may be for cooling a motor, such as an in-wheel vehicle motor.

Abstract: A channel structure includes a cooling channel continuously formed inside a housing. A coolant is configured to flow in the cooling channel. The cooling channel includes a plurality of channel portions spaced apart from each other and extending in the housing by changing directions.

Abstract: The present disclosure provides a sealing device and an in-wheel motor including the sealing device. The in-wheel motor includes a stator, a rotor rotatably disposed with respect to the stator, an annular inner seal connected to the stator and spaced apart from the rotor by a predetermined gap so as to be disposed between the stator and the rotor, and an annular slinger coupled to an end portion of the rotor, wherein the annular inner seal seals between the slinger and the in-wheel motor.

Abstract: A display device includes: a first base having a display area; light-emitting elements on the first base; and an encapsulation layer over the light-emitting elements. The encapsulation layer includes: a first inorganic layer; an organic layer on the first inorganic layer; and a second inorganic layer on the organic layer. The first inorganic layer includes: a first buffer layer on the light-emitting elements; a first barrier layer on the first buffer layer; a first porous layer on the first barrier layer; a second barrier layer on the first porous layer; and a second buffer layer on the second barrier layer. A refractive index of the first buffer layer, the first barrier layer, and the first porous layer are different from one another, and the refractive index of the first porous layer is smaller than the refractive index of the first buffer layer and the first barrier layer.

Abstract: The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.

Abstract: The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.

Abstract: The present invention relates to a novel method of purifying adefovir dipivoxil of Formula 1. The purification method according to the present invention comprises the steps of dissolving impure adefovir dipivoxil containing byproducts generated during a synthetic reaction, salts thereof or complexes thereof in water or a water-containing mixed solvent; purifying the adefovir dipivoxil solution through a reverse-phase column; and adding a base to the purified adefovir dipivoxil solution and extracting the same with an organic solvent. Further, the present invention provides a method of preparing amorphous adefovir dipivoxil by removing the solvent from the high purity solution of adefovir dipivoxil represented by formula I purified by the above method.

Abstract: The present invention relates to an amorphous solid dispersion with improved stability comprising 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine as a nucleotide analogue, a pharmaceutical composition comprising the same, and a method for preparing the same.