Patents by Inventor Yong Taik Lim

Yong Taik Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210161814
    Abstract: The present invention relates to a cryogel scaffold capable of controlling the degree of degradation and a soft bio-integrated device in which a drug modulating an immunosuppressive action in solid tumor microenvironment is loaded in the scaffold.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 3, 2021
    Applicant: Research & Business Foundation Sungkyunkwan University
    Inventors: Yong Taik LIM, Chanyoung SONG, Phuengkham HATHAICHANOK, Long REN
  • Publication number: 20200046831
    Abstract: The present invention relates to a nanoemulsion comprising an oil layer comprising imidazoquinoline-based toll-like receptor 7 or 8 agonist and oil, and a use thereof as an adjuvant and vaccine. According to the present invention, it is possible to provide a vaccine adjuvant in the form of a nanoemulsion that can dissolve an insoluble imidazoquinoline-based material in oil using a dispersion helper and disperse the oil solution easily and reproducibly in a water-soluble manner.
    Type: Application
    Filed: February 13, 2018
    Publication date: February 13, 2020
    Inventors: Yong Taik LIM, Sun-Young KIM
  • Patent number: 10543258
    Abstract: The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: January 28, 2020
    Assignee: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
    Inventors: Yeong Min Park, In Duk Jung, Yong Taik Lim, Jung Hee Park, Sung Jae Shin
  • Publication number: 20190380960
    Abstract: The present invention relates to a multi-domain vesicle comprising an immunostimulatory material, a production method of the multi-domain vesicle and an immunomodulatory composition comprising the multi-domain vesicle. According to one aspect of the present invention, the multi-domain vesicle comprises: at least two liposomes making contact and connected with each other, and a multi-domain vesicle outer wall surrounding the at least two liposomes.
    Type: Application
    Filed: March 2, 2018
    Publication date: December 19, 2019
    Inventor: Yong Taik LIM
  • Publication number: 20190380961
    Abstract: The present invention relates to a multi-domain vesicle comprising an immunosuppressive factor control material, a production method of the multi-domain vesicle and an immunomodulatory composition comprising the multi-domain vesicle. According to one aspect of the present invention, the multi-domain vesicle comprises: at least two liposomes making contact and connected with each other, and a multi-domain vesicle outer wall surrounding the at least two liposomes.
    Type: Application
    Filed: March 2, 2018
    Publication date: December 19, 2019
    Inventor: Yong Taik LIM
  • Publication number: 20190083581
    Abstract: The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 21, 2019
    Applicant: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
    Inventors: Yeong Min PARK, In Duk JUNG, Yong Taik LIM, Jung Hee PARK, Sung Jae SHIN
  • Patent number: 10058496
    Abstract: A thermosensitive ionic composite having a multistage phase transition characteristic, a method for preparing the thermosensitive ionic composite, and a biodegradable composition containing the thermosensitive ionic composite are provided.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: August 28, 2018
    Assignee: Research & Business Foundation Sungkyunkwan University
    Inventor: Yong Taik Lim
  • Patent number: 9623121
    Abstract: The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: April 18, 2017
    Assignees: BIOLEADERS CORPORATION, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOOKMIN UNIVERSITY INDUSTRY - ACADEMIC COOPERATION FOUNDATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee
  • Publication number: 20160193348
    Abstract: The present invention relates to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, and more particularly, to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, a preparation method thereof, and a drug delivery system employing the mucous membrane-adhesive property of the nanomicelles. According to the present invention, the nanomicelle drug delivery system based on poly-gamma-glutamic acid that is a natural biopolymer can be used for the delivery of a drug to mucous membranes to thereby increase the in vivo stability and effectiveness of the drug.
    Type: Application
    Filed: June 4, 2013
    Publication date: July 7, 2016
    Inventors: Jae-Chul Choi, Yong Taik Lim, Haryoung Poo, Moon-Hee Sung
  • Publication number: 20160158274
    Abstract: The present invention relates to a composition for dispersing or hydrating mucus, which comprises poly-gamma-glutamic acid, a biocompatible natural polymer, and more particularly, to a composition for treating mucus hypersecretory disease, which comprises poly-gamma-glutamic acid or poly-gamma-glutamic acid nanogels. The composition according to the present invention is effective in treating mucus-related diseases by effectively dispersing and hydrating mucus which is excessively secreted in vivo and highly sticky.
    Type: Application
    Filed: May 27, 2014
    Publication date: June 9, 2016
    Inventors: Il-Han Lee, Yong Taik Lim
  • Publication number: 20160114044
    Abstract: A composition for drug delivery based on a biocompatible anionic polymer and a producing method thereof are provided.
    Type: Application
    Filed: August 26, 2015
    Publication date: April 28, 2016
    Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, BIOLEADERS CORPORATION
    Inventors: Yong Taik LIM, Seung-Pyo HONG
  • Patent number: 9314520
    Abstract: The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: April 19, 2016
    Assignees: BIOLEADERS CORPORATION, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION
    Inventors: Moon-Hee Sung, Haryoung Poo, Chul Joong Kim, Young-Ki Choi, Yong Taik Lim, Dong Jin Jeong, Sang-Mu Shim
  • Publication number: 20160046809
    Abstract: A thermosensitive ionic composite having a multistage phase transition characteristic, a method for preparing the thermosensitive ionic composite, and a biodegradable composition containing the thermosensitive ionic composite are provided.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 18, 2016
    Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventor: Yong Taik LIM
  • Patent number: 9138491
    Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (?-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a ?-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (?-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (?PGA) and cationic chitosan.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 22, 2015
    Assignees: BIOLEADERS CORPORATION, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee, Hyun Min Kim
  • Patent number: 8758822
    Abstract: The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: June 24, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Yong Taik Lim, Jung Hyun Han
  • Publication number: 20140170077
    Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (?-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a ?-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (?-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (?PGA) and cationic chitosan.
    Type: Application
    Filed: April 7, 2011
    Publication date: June 19, 2014
    Applicants: THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM, BIOLEADERS CORPORATION
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, Il Han Lee, Hyun Min Kim
  • Patent number: 8753606
    Abstract: The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: June 17, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Yong Taik Lim
  • Publication number: 20140161727
    Abstract: The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination.
    Type: Application
    Filed: November 18, 2011
    Publication date: June 12, 2014
    Applicants: BIOLEADERS CORPORATION, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, THE INDUSTRY AND ACADEMIC IN CHUNGNAM NATIONAL UNIVERSITY
    Inventors: Moon-Hee Sung, Yong Taik Lim, Young-Woock Noh, II Han Lee
  • Patent number: 8734762
    Abstract: The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: May 27, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Yong Taik Lim, Bang Sil Choi, Jung Hyun Han
  • Patent number: 8697389
    Abstract: The present invention relates to cell labeling and imaging using a multifunctional perfluorocarbon (PFC) nanoemulsion. In particular, the perfluorocarbon nanoemulsion containing optical nanoparticle is provided with both optical characteristics and 19F magnetic resonance characteristics, thus can be used for magnetic resonance imaging (MRI) and optical imaging (OI) simultaneously. Cell labeling and imaging using the perfluorocarbon nanoemulsion containing quantum dot nanoparticle exerted no effect on cell viability. Therefore, perfluorocarbon nanoemulsion can be applied to methods for multifunctional and effectively cell labeling and imaging.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: April 15, 2014
    Assignee: Korea Research Institute of Bioscience And Biotechnology
    Inventors: Bong Hyun Chung, Yong Taik Lim