Abstract: The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters. According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.

Abstract: A complementary thin film transistor (TFT) includes a substrate and a first TFT and a second TFT disposed on the substrate, wherein a first conductive semiconductor layer of the first TFT and a second gate electrode layer of the second TFT are disposed in the same layer and include the same material.

Abstract: A display device includes a display panel having a folding axis extending in a first direction; and a panel supporter disposed on a surface of the display panel. The panel supporter includes a first layer including a first base resin and first fiber yarns extending in the first direction and dispersed in the first base resin, a second layer disposed on the first layer, the second layer including a second base resin and second fiber yarns extending in a second direction intersecting the first direction and dispersed in the second base resin, and a third layer disposed on the second layer, the third layer including a third base resin and third fiber yarns extending in the first direction and dispersed in the third base resin.

Abstract: The present disclosure relates to a functional cosmetic composition using broccoli exosomes as an active ingredient and a functional cosmetic product containing the same. The broccoli exosomes have a lipid bilayer structure and are well absorbed into skin cells, and the absorbed broccoli exosomes remove reactive oxygen within skin cells and stimulate anti-oxidant signaling mechanisms, so they show anti-oxidant efficacy, and promote hyaluronic acid synthesis, and thus, they can be useful for preparation of functional cosmetics for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

Abstract: The present disclosure relates to a pharmaceutical composition for relieving and treating pain based on exosomes. The exosomes according to the present disclosure contain various cytokines, gene, bioactive factors and proteins and the like related to nerve cell regeneration and pain relief secreted in the process of cell proliferation and cell behavior, and therefore, can heal fundamental causes which cause pain.

Abstract: The present disclosure relates to a new use of a tangential flow filtration device and a continuous concentration system for producing an ultra-high concentration medical exosome solution.

Abstract: A composition, for inducing chondrocyte differentiation or regenerating cartilage tissue or both, includes exosomes derived from stem cells differentiating into chondrocytes.

Abstract: The present disclosure relates to a large-scale production method of plant exosomes. The method of the present disclosure can isolate high purity plant exosomes from a large amount of raw plants, using centrifugation and TFF, which can process a large amount of plant raw materials at once. This improves a conventional isolation process of plant exosomes stayed at the laboratory level, and thereby, suggests an easy process for large-scale production.

Abstract: The present disclosure relates to a composition for preventing or treating pulmonary fibrosis, containing an exosome isolated from an adipose-derived stem cell as an active ingredient, a use of the exosome in preparation of a pharmaceutical for preventing or treating pulmonary fibrosis and a method for preventing pulmonary fibrosis, including a step of administering a pharmaceutical composition containing the exosome as an active ingredient to a subject.

Abstract: The present disclosure relates to a composition for inducing differentiation into beige adipocytes, which contains an exosome derived from stem cells differentiating into beige adipocytes as an active ingredient, a pharmaceutical composition, a health functional food and a differentiation medium composition containing the composition and a method for inducing differentiation into beige adipocytes using the same.

Abstract: The present disclosure relates to a composition for preventing or treating acute liver failure using exosomes. The inventors of the present disclosure have experimentally identified in an acute liver failure animal model that mice to which exosomes derived from adipose-derived mesenchymal stem cells were administered survived at higher rates, had improved levels of aspartate aminotransferase (AST) and alanine aminotransaminase (ALT) and exhibited superior apoptosis-inhibiting and anti-inflammatory effects, compared with mice to which the exosomes were not administered. Thus, the composition of the present disclosure can be usefully used for development of medical products, foods, etc. for preventing, alleviating or treating acute liver failure.

Abstract: The present invention relates to a method of treating a subject having drug-resistant cancer, comprising administering a composition comprising exosomes derived from differentiating stem cells as an active ingredient. The exosomes isolated differentiating stem cells according to the present invention have an excellent expression rate of bioactive factors affecting differentiation and have an effect of facilitating reprogramming of cancer stem cells and differentiating them into cancer cells with weakened drug resistance.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating osteoporosis comprising exosomes isolated from adipose tissue-derived stem cells as an active ingredient. The exosomes isolated from the adipose tissue-derived stem cells according to the present invention can facilitate osteogenesis and enhance bone density, and therefore it can be useful for prevention or treatment of osteoporosis.

Abstract: Provided are a method and a device for transmitting and receiving multimedia data. The present invention comprises: receiving of multimedia data and confirming of loss data; determining, with respect to the degree of the loss of the received data, of whether or not the lost data can be recovered by means of application layer forward error correction (AL-FEC); if data recovery by means of the AL-FEC is not possible, making of an automatic retransmission request (ARQ) with respect to the lost data; and receiving of data retransmitted with respect to the ARQ and recovering of the lost data.

Abstract: The present disclosure relates to a composition for inducing differentiation into beige adipocytes, which contains an exosome derived from stem cells differentiating into beige adipocytes as an active ingredient, a pharmaceutical composition, a health functional food and a differentiation medium composition containing the composition and a method for inducing differentiation into beige adipocytes using the same.

Abstract: A cosmetic composition for skin whitening, wrinkle improvement or skin regeneration includes, as an active ingredient, exosomes derived from stem cells comprising proliferating stem cells.

Abstract: A composition, for inducing chondrocyte differentiation or regenerating cartilage tissue or both, includes exosomes derived from stem cells differentiating into chondrocytes.

Abstract: A cosmetic composition for skin whitening, wrinkle improvement or skin regeneration includes, as an active ingredient, exosomes derived from stem cells comprising proliferating stem cells.

Abstract: A composition for inducing differentiation into adipocytes or regenerating adipose tissues comprises, as an ingredient, exosomes derived from stem cells differentiating into adipocytes, or exosomes derived from proliferating stem cells.

Abstract: Provided are a method and a device for transmitting and receiving multimedia data. The present invention comprises: receiving of multimedia data and confirming of loss data; determining, with respect to the degree of the loss of the received data, of whether or not the lost data can be recovered by means of application layer forward error correction (AL-FEC); if data recovery by means of the AL-FEC is not possible, making of an automatic retransmission request (ARQ) with respect to the lost data; and receiving of data retransmitted with respect to the ARQ and recovering of the lost data.