Abstract: Disclosed are macrocyclic peptide compounds or a salt thereof, which are useful as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds may be useful in treating cancers, inflammatory and autoimmune diseases.

Abstract: Disclosed are an equipment failure mode predetermination and residual life prediction coupling system and method. The equipment failure mode predetermination and residual life prediction coupling system realizes coupling of equipment failure mode predetermination and residual life prediction, continuous collection of health information of equipment, predetermination of the failure mode and prediction of the residual life based on the state of health of the equipment in operation monitored and perceived in real time by sensor sets.

Abstract: Embodiments of the present disclosure provide a display panel, a manufacturing method therefor, and a display apparatus. The display panel includes a first substrate and a second substrate which are aligned, liquid crystals are filled between the first substrate and the second substrate, the first substrate and the second substrate which are aligned have a display region and a peripheral region surrounding the display region, the peripheral region is provided with a frame sealing adhesive located between the first substrate and the second substrate and surrounding the display region, and the frame sealing adhesive is configured to seal the liquid crystals.

Abstract: A high-strength and tough multi-component soft magnetic alloy and preparation method thereof are provided. The high-strength and tough multi-component soft magnetic alloy is composed of the following components in atomic percentage: Fe 32-45%, Co 24-29%, Ni 24-29%, Al 2.5-8%, Ti 1.5-3.5%, Ta 1.0-5%, Nb 0-2%, and Mo 0-2%. The multi-component alloys prepared by the present invention exhibit a face-centered cubic structure of the matrix, featured with high strength, high ductility, low coercivity and relatively high saturation magnetization. These properties make it suitable for manufacturing critical components for applications in industries such as electrical engineering, automatic control, mobile communications, and others.

Abstract: The invention discloses a benzimidazole or azabenzimidazole compound, a preparation method therefor and use thereof. The benzimidazole or azabenzimidazole compound has a structure shown in formula (I). Use of the compound and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a hydrate thereof in preparing a GLP-1 receptor agonist and use thereof in preparation of a medicament for treating and/or preventing metabolic diseases.

Abstract: An array substrate, including a first substrate, and a plurality of gate lines and a plurality of data lines defining a plurality of subpixel regions each including a reflective region and a transmissive region, wherein the reflective region includes a reflective electrode, and the transmissive region includes a transmissive electrode; a first spacing region including a preset subregion is between two adjacent reflective electrodes in a first direction; the data line includes a first portion in the preset subregion, and a width of the first portion in the first direction is smaller than that of the preset subregion; and the array substrate further includes a first light shielding pattern opposite to the first portion and in the same layer as the gate lines, where an orthographic projection of the first light shielding pattern on the first substrate completely covers an orthographic projection of the preset subregion on the first substrate.

Abstract: A method of evaluating an ability of a large language model (LLM) to generate an accurate hypothesis model (HM) of a linear programming word problem (LPWP) is provided. An attributed bipartite graph of the HM is transformed into an attributed bipartite graph of the ground truth model of the LPWP. The number of transformation steps required for the transformation effectively measures the ability of the LLM to generate an accurate HM. The use of attributed bipartite graphs provide invariance in the order to LPWP variables and constraints. Corresponding apparatus and systems are also provided.

Abstract: Systems and methods embedding a frequency domain-based watermark in tabular data are provided. In some methods, a covariance matrix is computed for the tabular data. Row vectors of the tabular data are projected onto two orthonormal vectors e1, e2 of the covariance matrix. A signal space for the projected row vectors is determined. A frequency f* with a lowest power from the signal space is located. A watermark is embedded in the tabular data based on the frequency f*.

Abstract: A virtual object control method is provided. The method includes: displaying a battle interface, the battle interface including a first virtual object, at least one second virtual object, and a first control; determining a target virtual object from the at least one second virtual object, and labeling the target virtual object in a predetermined manner; receiving a first trigger signal acting on the first control; and controlling, in response to determining that the first trigger signal meets an automatic control condition, the first virtual object to use a virtual prop to change a target attribute value of the target virtual object.

Abstract: Embodiments of this application provide a screen refresh rate switching method, an electronic device, and a computer-readable storage medium. The method includes: when a screen is in an idle state, setting, if a plurality of preset conditions are met, a refresh rate of the screen to a first refresh rate, where the plurality of preset conditions includes that a screen luminance is less than a preset screen luminance threshold, an ambient light luminance is less than a preset ambient light luminance threshold, and a proportion of low grayscale pixels of an image that is currently displayed on the screen is greater than a preset proportion; and setting, if none of the plurality of preset conditions is met, the refresh rate of the screen to a second refresh rate, where the second refresh rate is less than the first refresh rate.

Abstract: Provided is a light source device, including a first laser light source group, a second laser light source group, a dichroic mirror, a fluorescence converter, and an emission component. The first laser light source group emits laser light of a first waveband, and the second laser light source group emits laser light of a second waveband and laser light of a third waveband. The dichroic mirror is disposed on light-output sides of the first laser light source group and the second laser light source group, and the fluorescence converter and the emission component are respectively disposed on light-output sides of the dichroic mirror. The dichroic mirror is configured to emit laser light of various wavebands, and the fluorescence converter generates target fluorescence under the excitation of the laser light of the first waveband, and the target fluorescence is reflected by the dichroic mirror to the emission component.

Abstract: A bispecific antibody simultaneously targeting two different epitopes or targets is coupled with a camptothecin drug to form a bispecific antibody-toxin conjugate that is stable in treatment and excellent in uniformity, and a drug-to-antibody ratio (DAR) thereof is 6.0-8.0. The antibody-toxin conjugate has a structure as represented by general formula (I), wherein Ab represents the bispecific antibody simultaneously targeting two different epitopes or targets, which is coupled with a linker-camptothecin drug. In addition, the present invention further relates to a preparation and purification method for the antibody-toxin conjugate, and an application thereof in tumor treatment. Furthermore, the present invention further relates to a linker-drug compound capable of being coupled with Ab to form the antibody-toxin conjugate.

Abstract: Methods, apparatus and systems are described that relate to uncooled long-wave infrared (LWIR) photodetectors capable of operating at room temperature and having a simple structure that can be manufactured at low cost. One example LWIR photodetector includes a layer of amorphous silicon (a-Si) disposed on a silicon substrate and a layer of amorphous germanium (a-Ge) disposed on the a-Si layer, wherein the a-Ge layer is operable to absorb infrared light and provide photoconductive gain, and the a-Si layer is operable to produce carrier multiplication via cycling excitation process.

Abstract: Systems, methods, and computer-readable media are provided for variable precision first in, first out (FIFO) buffers (VPFB) that dynamically changes the amount of data to be stored in the VPFB based on a current amount of data stored in the VPFB and/or based on a current amount of available memory space of the VPFB. The currently unavailable memory space (or the current available memory space) is used to select the size of a next data block to be stored in the VPFB. Other embodiments are disclosed and/or claimed.

Abstract: A distributed storage method includes offline merging, by a first thread service of a distributed storage system, M small files in a file system; generating, by the first thread service, M pieces of metadata in the offline merging process; loading, by a second thread service of the distributed storage system, the M pieces of metadata into a metadata set; searching, by the second thread service, the metadata set for metadata of a first small file when the second thread service receives a first instruction; and performing, by the second thread service, the operation corresponding to the first instruction when the second thread service finds the metadata of the first small file in the metadata set.

Abstract: The present disclosure provides a display panel. The display panel includes a base substrate, a first conductive layer and an active layer that are stacked in sequence. The first conductive layer includes a plurality of gate signal lines. The gate signal line includes a body part and a plurality of additional parts. An orthographic projection of the body part on the base substrate extends along a first direction. The plurality of additional parts are distributed at intervals in the first direction and coupled to a side of the body part in a second direction. The additional part is used to form a gate of a driving transistor. The active layer includes a plurality of active structures disposed corresponding to the plurality of additional parts. Orthographic projections of the plurality of active structures on the base substrate are separated from each other.