Patents by Inventor Yongbi Chen

Yongbi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of refining valsartan comprising more than or equal to 10% D-isomers
    Patent number: 9815801
    Abstract: The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than or equal to 10% D-isomers to dissolve it, then adding a certain amount of inorganic base, separating solids out after salification, distilling a filtrate after filtration, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate with an acid, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables isomers of the product to be below 0.5%, and produce a yield of more than or equal to 40%, being suitable for industrial production.
    Type: Grant
    Filed: February 15, 2015
    Date of Patent: November 14, 2017
    Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.
    Inventors: Yongbi Chen, Wenling Zhang, Peng Wang, Jian Chen
  • METHOD OF REFINING VALSARTAN COMPRISING MORE THAN OR EQUAL TO 10% D-ISOMERS
    Publication number: 20160347723
    Abstract: The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than or equal to 10% D-isomers to dissolve it, then adding a certain amount of inorganic base, separating solids out after salification, distilling a filtrate after filtration, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate with an acid, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables isomers of the product to be below 0.5%, and produce a yield of more than or equal to 40%, being suitable for industrial production.
    Type: Application
    Filed: February 15, 2015
    Publication date: December 1, 2016
    Inventors: Yongbi Chen, Wenling Zhang, Peng Wang, Jian Chen