Patents by Inventor Yongbo Peng

Yongbo Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL ANTIBODY TARGETING SIRPa AND USE THEREOF
    Publication number: 20240368301
    Abstract: The present invention relates to the field of biomedicine, specifically to a monoclonal antibody targeting SIRP?, and a preparation method and the use thereof. The SIRP? antibody or the antigen-binding portion thereof prepared by the present invention has a high affinity for SIRP? and a low affinity for SIRP?, which differ by two orders of magnitude. The SIRP? antibody or the antigen-binding portion thereof can efficiently block the binding of CD47 to SIRP?-V1, SIRP?-V2 and SIRP?-V8, thereby promoting the activation of macrophages, particularly enhancing the regulatory antibody-dependent cellular phagocytosis (ADCP) of a target tumor cell, bridging about innate and adaptive immune responses, and promoting the synergistic anti-cancer effect of the SIRP? antibody or the antigen-binding portion thereof with a checkpoint inhibitor PD-(L)1 monoclonal antibody. The antibody can be used for treating various cancers and microbial infectious diseases.
    Type: Application
    Filed: August 16, 2022
    Publication date: November 7, 2024
    Inventors: Lizhen HE, Pin YU, Feihu XU, Liang ZHOU, Xuancheng GUO, Yongbo PENG, Hong CHEN, Tongying WANG, Handong SUN, Chen LI
  • 6-SHOGAOL FOR USING IN A METHOD FOR THE TREATMENT OF LEUKEMIA
    Publication number: 20110136916
    Abstract: The present invention relates to the field of natural drugs, particularly to 6-shogaol for using in a method for the treatment of leukemia. The present invention provides a method for treating leukemia by applying a therapeutically effective dose of 6-shogaolt and this therapeutic method can be used for treating leukemia in mammals including human being.
    Type: Application
    Filed: November 3, 2010
    Publication date: June 9, 2011
    Applicant: China Pharmaceutical University
    Inventors: Ping Li, Yongbo Peng, Lianwen Qi, Xiaodong Wen, Jiang Ma, Ping Zhou, Lei Zhang, Qun Liu, Ehu Liu, Jun Chen