Patents by Inventor Yongchun Chen

Yongchun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220144832
    Abstract: The present invention relates to crystalline forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, and related synthetic intermediates, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Zhongjiang Jia, Shili Chen, Mei Li, Pingli Liu, Yongchun Pan, Yongzhong Wu, Jiacheng Zhou
  • Publication number: 20220144830
    Abstract: The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Jiacheng Zhou, Shili Chen, Zhongjiang Jia, Yi Li, Qiyan Lin, Pingli Liu, Yongchun Pan, Timothy Martin, Bo Shen, Chongsheng Eric Shi, Naijing Su, Yongzhong Wu, Michael Xia
  • Publication number: 20220010051
    Abstract: A polyurethane composition reaction mixture including: (a) at least one organic isocyanate; and (b) at least one butylene oxide-based hydrophobic polyol; a process for making the above polyurethane composition; a polyurethane composite article composition, a process for making the above polyurethane composite article composition; and a process for making a composite article from the above polyurethane composite article composition.
    Type: Application
    Filed: September 28, 2018
    Publication date: January 13, 2022
    Inventors: Hua Ren, Beilei Wang, Huan Chen, Yongchun Chen, Dong Yun, Cheng Shen
  • Patent number: 11015092
    Abstract: A composition comprising, in weight percent (wt %) based on the weight of the composition: (A) greater than zero to 39 wt % of at least one of a polar olefin polymer and a styrenic block copolymer; (B) greater than zero to 20 wt % of an epoxy or amine-functionalized silane; (C) 60 to 99 wt % of an organic solvent for a mixture of (1) the polar olefin polymer and/or styrenic block copolymer, and (2) the epoxy or amine-functionalized silane; and (D) zero to 10 wt % of a polyisocyanate crosslinking agent.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: May 25, 2021
    Assignee: Dow Global Technologies LLC
    Inventors: Yongchun Chen, Hang Wu, Tao Han, Haiyang Yu
  • Patent number: 10870257
    Abstract: The present disclosure is directed to a process for preparing foamed articles comprising at least one ethylene/?-olefin interpolymer and use of the foamed articles in various applications, such as footwear applications. The ethylene/?-olefin interpolymers of the present disclosure are multi-block copolymers comprising at least one soft block and at least one hard block.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: December 22, 2020
    Assignee: Dow Global Technologies LLC
    Inventors: Haiyang Yu, Xiaochun Liu, Yongchun Chen
  • Patent number: 10793709
    Abstract: A novel polymer mixture having fast drying time, a multilayer article comprising at least two layers of the dried polymer mixture and having good mechanical properties, water resistance and weatherability, and a method of preparing the multilayer article.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 6, 2020
    Assignee: Dow Global Technologies LLC
    Inventors: Liang Zhang, Jingui Jiang, Yongchun Chen, Yan Li, Wei Li
  • Patent number: 10767082
    Abstract: Polymer compositions for UV curable primer formulations, as described herein. The primer formulations contain a modifier selected from the following: at least one modifier selected from a) through d) below: a) R1R2C?CR3-(CO)—Z (Formula A), as described herein, b) an acrylate-containing oligomer that has a Mn?1500 g/mol, and an acid value from 50 to 500 mg KOH/g; c) a random terpolymer comprising, in polymerized form, vinyl chloride, vinyl acetate, and at least one of the following: a hydroxyl-containing alkyl acrylate, a hydroxyl-containing alkyl meth-acrylate, or a combination thereof or d) any combination of a) through c). Such primer formulations are useful for the binding of olefin-based polymer foams.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 8, 2020
    Assignee: Dow Global Technologies LLC
    Inventors: Haiyang Yu, Qichun Wan, Yongchun Chen, Shaoguang Feng
  • Patent number: 10752770
    Abstract: Embodiments of this invention relate to a composition comprising of (A) an anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer and/or (b) a styrene-based polymer and/or a functionalized styrene-based polymer, (B) a polyamide wax slurry, and (C) organic solvent, and which composition can be used as an adhesive to bond a fabric to a polyolefin elastomer (POE) thermoplastic sheet, articles made from the composition, and methods of producing the composition and articles.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 25, 2020
    Assignee: Dow Global Technologies LLC
    Inventors: Yongchun Chen, Hang Wu, Haiyang Yu, Weiming Ma, Hong Yang, Xiao Yi Pang
  • Publication number: 20200164615
    Abstract: The present disclosure is directed to a process for preparing foamed articles comprising at least one ethylene/?-olefin interpolymer and use of the foamed articles in various applications, such as footwear applications. The ethylene/?-olefin interpolymers of the present disclosure are multi-block copolymers comprising at least one soft block and at least one hard block.
    Type: Application
    Filed: March 14, 2016
    Publication date: May 28, 2020
    Inventors: Haiyang Yu, Xiaochun Liu, Yongchun Chen
  • Patent number: 10618259
    Abstract: A coated substrate which includes a) a fabric substrate layer; b) an adhesive layer which is formed from a first composition comprising a thermoplastic elastomer and an anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer that has a chlorine content from 1 to 20 wt %, based on the total weight of the anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer and the thermoplastic elastomer; and c) a non-polar olefin-based layer formed from a second composition comprising at least one non-polar olefin-based polymer is provided. Also provided are an adhesive composition and articles comprising the coated substrate.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: April 14, 2020
    Assignee: Dow Global Technologies LLC
    Inventors: Haiyang Yu, Yong Chen, Yongchun Chen, Hang Wu
  • Publication number: 20190203084
    Abstract: A composition comprising, in weight percent (wt %) based on the weight of the composition: (A) greater than zero to 39 wt % of at least one of a polar olefin polymer and a styrenic block copolymer; (B) greater than zero to 20 wt % of an epoxy or amine-functionalized silane; (C) 60 to 99 wt % of an organic solvent for a mixture of (1) the polar olefin polymer and/or styrenic block copolymer, and (2) the epoxy or amine-functionalized silane; and (D) zero to 10 wt % of a polyisocyanate crosslinking agent.
    Type: Application
    Filed: August 23, 2016
    Publication date: July 4, 2019
    Inventors: Yongchun Chen, Hang Wu, Tao Han, Haiyang Yu
  • Publication number: 20190084284
    Abstract: A method for bonding a fabric to a polyolefin elastomer. The method comprises applying to the fabric: (a) from 10 to 90 wt % of an aqueous dispersion of a thermoplastic polymer; and (b) from 90 to 10 wt % of an aqueous dispersion of a rosin, wherein percentages are based on total dry weight of thermoplastic polymer and rosin.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Inventors: Yong Chen, Yongchun Chen, Weichao Gu, Yongfu Liang, Xiao Yi Pang, Haiyang Yu
  • Publication number: 20180346707
    Abstract: Embodiments of this invention relate to a composition comprising of (A) an anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer and/or (b) a styrene-based polymer and/or a functionalized styrene-based polymer, (B) a polyamide wax slurry, and (C) organic solvent, and which composition can be used as an adhesive to bond a fabric to a polyolefin elastomer (POE) thermoplastic sheet, articles made from the composition, and methods of producing the composition and articles.
    Type: Application
    Filed: November 23, 2016
    Publication date: December 6, 2018
    Inventors: Yongchun Chen, Hang Wu, Haiyang Yu, Weiming Ma, Hong Yang, Xiao Yi Pang
  • Patent number: 9771318
    Abstract: Provided is a composition comprising one or more compound having the structure of formula II: wherein A is a residue of a polyisocyanate, L is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, n is 5 to 25, m is 0 to 100, and Z is methyl or ethyl or propyl, and wherein the ratio of the sum of the moles of isocyanate groups plus the moles of said L groups to the moles of said Z groups is 2:1 to 30:1. Also provided is an emulsion in which the particles comprise such a composition and further comprise one or more water-insoluble compound that does not have the structure A-NCO.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: September 26, 2017
    Assignees: Rohm and Haas Company, Dow Global Technologies LLC
    Inventors: Yongchun Chen, Shiling Zhang, Ling Yuan, Guoling Hou
  • Publication number: 20170217142
    Abstract: A method for bonding a fabric to a polyolefin elastomer. The method comprises applying to the fabric: (a) from 10 to 90 wt % of an aqueous dispersion of a thermoplastic polymer; and (b) from 90 to 10 wt % of an aqueous dispersion of a rosin, wherein percentages are based on total dry weight of thermoplastic polymer and rosin.
    Type: Application
    Filed: July 17, 2014
    Publication date: August 3, 2017
    Inventors: Yong Chen, Yongchun Chen, Weichao Gu, Yongfu Liang, Xiao Yi Pang, Haiyang Yu
  • Publication number: 20170106635
    Abstract: A coated substrate which includes a) a fabric substrate layer; b) an adhesive layer which is formed from a first composition comprising a thermoplastic elastomer and an anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer that has a chlorine content from 1 to 20 wt %, based on the total weight of the anhydride and/or carboxylic acid functionalized, chlorinated olefin-based polymer and the thermoplastic elastomer; and c) a non-polar olefin-based layer formed from a second composition comprising at least one non-polar olefin-based polymer is provided. Also provided are an adhesive composition and articles comprising the coated substrate.
    Type: Application
    Filed: June 11, 2015
    Publication date: April 20, 2017
    Inventors: Brian Yu, Yong Chen, Yongchun Chen, Hang Wu
  • Publication number: 20160251507
    Abstract: A novel polymer mixture having fast drying time, a multilayer article comprising at least two layers of the dried polymer mixture and having good mechanical properties, water resistance and weatherability, and a method of preparing the multilayer article.
    Type: Application
    Filed: October 11, 2013
    Publication date: September 1, 2016
    Applicant: Dow Chemical (China) Investment Company Limited
    Inventors: Liang Zhang, Jingui Jiang, Yongchun Chen, Yan Li, Wei Li
  • Publication number: 20150337089
    Abstract: Provided is a composition comprising (a) one or more polyisocyanate, wherein said polyisocyanate has the structure of formula I: A-NCO??I and (b) one or more compound having the structure of formula II: A-L-Q-G??II wherein A in structure II is identical to A in structure I, L is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, Q is an organic group, and G is an anionic group, and wherein the ratio of the sum of the moles of isocyanate groups plus the moles of said L groups to the moles of said Q groups is 3:1 to 10:1. Also provided is an emulsion in which the particles comprise such a composition and further comprise (c) one or more water-insoluble compound that is different from said polyisocyanate (a).
    Type: Application
    Filed: October 28, 2013
    Publication date: November 26, 2015
    Inventors: Yongchun CHEN, Guoling HOU, Shiling ZHANG
  • Publication number: 20150274649
    Abstract: Provided is a composition comprising one or more compound having the structure of formula II: wherein A is a residue of a polyisocyanate, L is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, n is 5 to 25, m is 0 to 100, and Z is methyl or ethyl or propyl, and wherein the ratio of the sum of the moles of isocyanate groups plus the moles of said L groups to the moles of said Z groups is 2:1 to 30:1.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 1, 2015
    Inventors: Yongchun Chen, Shiling Zhang, Ling Yuan, Guoling Hou
  • Publication number: 20150265991
    Abstract: Provided is a composition comprising (a1) one or more compound that is a trimer of a diisocyanate that has structure A1-NCO; (b1) one or more compound having the structure A1-L1-(CH2CH2O)n—Z; (a2) one or more compound that is a trimer of a diisocyanate that has structure A2-NCO; and (b2) one or more compound having the structure A2-L2-Q-G; wherein A1 in structure II-1 is identical to A1 in structure I-1, L1 is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, n is 5 to 25, Z is an alkyl group, A2 in structure II-2 is identical to A2 in structure I-2, L2 is a linking group formed by a reaction of an isocyanate group with an isocyanate-reactive group, Q is an organic group, G is an anionic group, A1 and A2 may be identical or different, wherein wa1+wa2 is 0% to 90%, wherein wa1 is the weight percent of said compound (a1), based on the total solids weight of said composition, wherein wa2 is the weight percent of said compound (a2), based on the total solids weight of
    Type: Application
    Filed: October 28, 2013
    Publication date: September 24, 2015
    Inventors: Yongchun CHEN, Shiling ZHANG, Guoling HOU, Mai CHEN