Abstract: An exemplary system, method, and computer-accessible medium for generating computed tomography (“CT”) image(s) of a subject(s) can be provided which can include receiving low dose CT imaging information for the subject(s), where the low dose CT imaging information can be based on a radiation dose of less than about 50 mAs, receiving a priori CT image data, and generating the CT image(s) based on the low dose CT imaging information and the a priori CT image data. A further CT images(s) can be generated based on the CT image(s) and the a priori CT image data. The a priori CT image data can include a set of Markov Random Field (MRF) coefficients derived from high dose or full dose CT image data.