Patents by Inventor Yongfu Liu

Yongfu Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC TLR7 AGONIST, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20240124486
    Abstract: A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.
    Type: Application
    Filed: September 26, 2021
    Publication date: April 18, 2024
    Inventors: Guozhi TANG, Dawei MA, Mengwei HUANG, Yongfu LIU, Yingyi WANG
  • Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease
    Patent number: 11708344
    Abstract: The present invention provides novel compounds having the general formula (Formula I): wherein R1 to R6, G1, G2, A1 to A4 and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: July 25, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dongdong Chen, Song Feng, Min Jiang, Yongfu Liu, Jiamin Zheng
  • FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20230074887
    Abstract: The present invention provides novel compounds having the general formula (Formula I): wherein R1 to R6, G1, G2, A1 to A4 and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 1, 2019
    Publication date: March 9, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Min JIANG, Yongfu LIU, Jiamin ZHENG
  • CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220402897
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 22, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Chungen LIANG, Yongfu LIU, Xuefei TAN, Jun WU, Jianping WANG
  • CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220388972
    Abstract: The present invention provides compounds having the general formula (I) wherein R1 to R10, Gi, G2, X and m are as described herein, compositions including the compounds and methods of using the compounds for treating hepatitis B.
    Type: Application
    Filed: December 12, 2019
    Publication date: December 8, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Yongfu LIU, Xuefei TAN, Jiamin ZHENG
  • FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220363657
    Abstract: The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.
    Type: Application
    Filed: September 11, 2019
    Publication date: November 17, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Chungen LIANG, Yongfu LIU, Hong SHEN, Xuefei TAN, Jun WU, Dongdong CHEN, Chao LI, Li WANG
  • HEXAHYDRO-1H-PYRAZINO[1,2-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20220340597
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, n and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 7, 2020
    Publication date: October 27, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Wei ZHU, Zhiwei ZHANG, Zhisen ZHANG, Hong SHEN, Yongfu LIU, Yafei LIU, Haixia LIU, Buyu KOU, Fabian DEY, Lue DAI, Linuo ZHU
  • N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220169639
    Abstract: The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 2, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Jiamin ZHENG, Yongfu LIU, Dongdong CHEN, Hong SHEN, Xuefei TAN
  • Spirodiamine derivatives as aldosterone synthase inhibitors
    Patent number: 10035804
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: July 31, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Kurt E. Amrein, Junli Chen, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Dongbo Li, Hans Peter Maerki, Rainer E. Martin, Alexander Mayweg, Xuefei Tan, Jun Wu, Jianhua Yu
  • Dihydroquinoline pyrazolyl compounds
    Patent number: 9796726
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R10, R11, R12, R13, R14, R15, R16, R17 and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 24, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Dongbo Li, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Jun Wu
  • Dihydroquinoline pyrazolyl compounds
    Patent number: 9796702
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, m and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 24, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Dongbo Li, Jun Wu
  • Pyridinyloxy- and phenyloxy-pyrazolyl compounds
    Patent number: 9790217
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 17, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Dongbo Li, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Jun Wu
  • NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS
    Publication number: 20170226116
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R10, R11, R12, R13, R14, R15, R16, R17 and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Dongbo Li, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Jun Wu
  • PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS
    Publication number: 20170226097
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Benoit Hornsperger, Bernd Kuhn, Dongbo Li, Yongfu Liu, Hans P. Maerki, Rainer E. Martin, Alexander V. Mayweg, Xuefei Tan, Lisha Wang, Jun Wu
  • Compounds for the treatment and prophylaxis of respiratory syncytial virus disease
    Patent number: RE49481
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: April 4, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Song Feng, Lu Gao, Tao Guo, Mengwei Huang, Chungen Liang, Yongfu Liu, Lisha Wang, Jason Christopher Wong, Jim Zhen Wu, Xihan Wu, Hongying Yun, Xiufang Zheng
  • Tire
    Patent number: D1016726
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: March 5, 2024
    Assignee: TIANJIN WANDA TYRE CO., LTD.
    Inventors: Peng Geng, Chuan Liu, Yongfu Guan
  • Tire
    Patent number: D1016727
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: March 5, 2024
    Assignee: TIANJIN WANDA TYRE CO., LTD.
    Inventors: Peng Geng, Chuan Liu, Yongfu Guan
  • Tire
    Patent number: D1016728
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: March 5, 2024
    Assignee: TIANJIN WANDA TYRE CO., LTD.
    Inventors: Peng Geng, Chuan Liu, Yongfu Guan
  • Tire
    Patent number: D1016729
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: March 5, 2024
    Assignee: TIANJIN WANDA TYRE CO., LTD.
    Inventors: Peng Geng, Chuan Liu, Yongfu Guan
  • Tyre
    Patent number: D1023903
    Type: Grant
    Filed: November 15, 2022
    Date of Patent: April 23, 2024
    Inventors: Chuan Liu, Yongfu Guan, Kaiyun Song, Peng Geng, Weina Hu