Patents by Inventor Yonghan CHEN

Yonghan CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for synthesizing etelcalcetide
    Patent number: 10647742
    Abstract: Provided is a method for solid phase synthesis of Etelcalcetide, comprising synthesizing Etelcalcetide backbone peptide resin, removing the side chain protecting group of Cys in the peptide chain, and then activating the sulfydryl group of the Cys side chain on the peptide resin with 2,2?-dithiodipyridine and constructing a disulfide bond with L-Cys, such that a crude Etelcalcetide peptide is obtained by cleaving. The method does not require undergoing multi-step purification, the yield and purity of the obtained crude peptide are relatively high, and the total yield of the refined peptide after purification is greatly increased.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 12, 2020
    Assignee: HYBIO PHARMACEUTICAL CO., LTD.
    Inventors: Yonghan Chen, Pengcheng Mi, Anjin Tao, Jiancheng Yuan
  • METHOD FOR SYNTHESIZING ETELCALCETIDE
    Publication number: 20190010185
    Abstract: Provided is a method for solid phase synthesis of Etelcalcetide, comprising synthesizing Etelcalcetide backbone peptide resin, removing the side chain protecting group of Cys in the peptide chain, and then activating the sulfydryl group of the Cys side chain on the peptide resin with 2,2?-dithiodipyridine and constructing a disulfide bond with L-Cys, such that a crude Etelcalcetide peptide is obtained by cleaving. The method does not require undergoing multi-step purification, the yield and purity of the obtained crude peptide are relatively high, and the total yield of the refined peptide after purification is greatly increased.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 10, 2019
    Applicant: HYBIO PHARMACEUTICAL CO., LTD.
    Inventors: Yonghan CHEN, Pengcheng MI, Anjin TAO, Jiancheng YUAN