Abstract: The disclosure provides a method for monitoring a short-term voltage stability of a power system. The method includes: obtaining a topology and time series of a current power system; inputting the topology and the time series of the current power system into a trained spatial-temporal graph network model, the trained spatial-temporal graph network model being obtained by classification learning on a spatial-temporal graph network model based on a simulation sample dataset; outputting a status of the short-term voltage stability of the power system; and sending an alarm signal in response to outputting an unstable status of the short-term voltage stability of the power system.

Abstract: Provided are an auxiliary alloy casting piece, a high-remanence and high-coercive force NdFeB permanent magnet, and preparation methods thereof. The method for preparing the auxiliary alloy casting piece includes the following steps: providing an auxiliary alloy material including, by mass percentage, 40% to 45% of Pr, 1% to 2% of Co, 0.5% to 1% of Ga, 0.6% to 0.8% of B, 0.1% to 0.2% of V, 0.3% to 0.7% of Ti, and a balance of Fe; smelting the auxiliary alloy material to obtain a smelted material; and subjecting the smelted material to a quick-setting casting to obtain the auxiliary alloy casting piece; where the quick-setting casting includes a refining and a casting in sequence.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Provided herein are targeting peptides and vectors containing a sequence that encodes the targeting peptides that deliver agents to specific substructures in the brain.

Abstract: In order to overcome the problems in existing lithium ion batteries having high compactness and high-specific-surface-area negative electrodes of serious side reactions of electrolytes and high gas production, the present invention provides a lithium ion battery, comprising a positive electrode, a negative electrode, and a non-aqueous electrolyte. The negative electrode comprises a negative electrode material layer, the compaction density of the negative electrode material layer is greater than or equal to 1.4 g/cm3, and the negative electrode material layer comprises a negative electrode active material, and the non-aqueous electrolyte comprises a solvent, an electrolyte salt, a vinylene carbonate, a fluoroethylene carbonate, and an unsaturated phosphate represented by structural formula 1, and the electrolyte salt comprises LiPF6 and LiFSI. The lithium ion battery provided by the present invention has good cycle performance, high and low temperature storage performance, and lithium precipitation resistance.

Abstract: The present disclosure relates to a method and system for evaluating the macro resilience of offshore oil well control equipment. The method for evaluating the macro resilience of offshore oil well control equipment comprises six steps: determining the type and strength of external disaster; calculating the failure rate of components; calculating the recovery rate of the components; modeling the BN for a degradation process; modeling the BN for a maintenance process; and calculating the resilience of the offshore oil well control equipment. A system for evaluating the macro resilience of offshore oil well control equipment comprises an external disaster evaluation module, a component failure rate calculation subsystem, a reliability degradation process simulation module, a fault identification module, a component recovery rate calculation module, a reliability recovery process simulation module, a reliability change curve derivation unit and an resilience calculation unit.

Abstract: The present disclosure belongs to the field of petroleum engineering, and specifically relates to a subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network. The subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network includes three steps: digital twin model establishment, degradation process re-prediction model establishment, and remaining useful life calculation model establishment.

Abstract: The disclosure provides a milling system and method under different lubrication conditions. The system uses a tool to mill the workpiece, a force measuring system to measure the milling force, a tool change system to replace the tools, a tool storage to store the tools. It can store the tools, provide the lubricating oil to the milling surface, select different tools according to different processing conditions, select the best angle differences of the unequal spiral angle tools according to different conditions comprising dry cutting, casting-type lubrication, minimal quantities of lubrication or minimal quantities of nanofluid lubrication, and/or choose the optimal tool according to different cutting parameters in order to obtain the minimum milling force.

Abstract: The present disclosure belongs to the field of petroleum engineering, and specifically relates to a subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network. The subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network includes three steps: digital twin model establishment, degradation process re-prediction model establishment, and remaining useful life calculation model establishment.

Abstract: The present disclosure belongs to the field of marine engineering, and in particular relates to a method and system for guaranteeing the safety of offshore oil well control equipment. The method comprises: identifying the state of a main structure of the offshore oil well control equipment, identifying the state of a hydraulic control unit of offshore oil well control equipment, identifying the state of an electronic control unit of offshore oil well control equipment, predicting the state of the offshore oil well control equipment and making a real-time decision based on existing information; and the system for guaranteeing the safety of the offshore oil well control equipment comprises a state identification subsystem of a main structure, a state identification subsystem of the hydraulic control unit, a state identification subsystem of the electronic control unit and a state prediction and real-time decision subsystem.

Abstract: A multi-path combined high-low voltage plasma drilling method, a drill bit for drilling and a drill bit apparatus for drilling utilizing this method. The drilling method includes: disposing a plurality of mutually independent plasma generators on a plasma drill bit, wherein the plasma generators are independently connected to a plasma power source on the ground through wires; allowing each of the plasma generators to eject high-frequency pulsed plasma arc under the control of its corresponding combined high-low voltage pulse power source on the ground; ejecting the high-frequency pulsed plasma arc onto a wall of a drilling well, forming impulsive high temperature thermal shock stress inside the rocks on the wall of the drilling well; and breaking the rocks under the shock of thermal stress to form rock debris.

Abstract: An embodiment of the present disclosure provides a multi-path combined high-low voltage plasma drilling power source and drilling system. The multi-path combined high-low voltage plasma drilling power source comprises a high-voltage DC circuit, low-voltage DC circuits, high-voltage breakdown modules and an upper computer; wherein the high-voltage DC circuit is connected with the low-voltage DC circuits through cables; the low-voltage DC circuits and the high-voltage breakdown modules simultaneously supply power to plasma generators through cables; the upper computer monitors the low-voltage DC circuits in real time; and the same power source comprises a plurality of low-voltage DC circuits and high-voltage breakdown modules.

Abstract: The present disclosure belongs to the field of offshore oil, and in particular relates to a method for assessing the safety integrity level of offshore oil well control equipment. The method for assessing the safety integrity level of the offshore oil well control equipment comprises three major steps: creating a safety instrumented function evaluation module and dividing the related devices for performing the safety instrumented functions into a sensor subsystem; a controller subsystem and an actuator subsystem, establishing a dynamic Bayesian network model for respective subsystems for calculation; and integrating, analyzing and optimizing the safety integrity data of the subsystems.

Abstract: The disclosure provides a milling system and method under different lubrication conditions. The system uses a tool to mill the workpiece, a force measuring system to measure the milling force, a tool change system to replace the tools, a tool storage to store the tools. It can store the tools, provide the lubricating oil to the milling surface, select different tools according to different processing conditions, select the best angle differences of the unequal spiral angle tools according to different conditions comprising dry cutting, casting-type lubrication, minimal quantities of lubrication or minimal quantities of nanofluid lubrication, and/or choose the optimal tool according to different cutting parameters in order to obtain the minimum milling force.

Abstract: The disclosure provides a milling system and method under different lubrication conditions. The system uses a tool to mill the workpiece, a force measuring system to measure the milling force, a tool change system to replace the tools, a tool storage to store the tools. It can store the tools, provide the lubricating oil to the milling surface, select different tools according to different processing conditions, select the best angle differences of the unequal spiral angle tools according to different conditions comprising dry cutting, casting-type lubrication, minimal quantities of lubrication or minimal quantities of nanofluid lubrication, and/or choose the optimal tool according to different cutting parameters in order to obtain the minimum milling force.

Abstract: The disclosure provides a method and system for injecting cutting fluid during milling under different working conditions. By analyzing influence of an airflow field in a milling area under different working conditions on injection of cutting fluid, an influence rule of a helical angle and a rotation speed of a cutter on the flow field is quantitatively analyzed, an optimal target distance of a nozzle, an angle between the nozzle and a milling cutter feeding direction and an angle between the nozzle and the surface of a workpiece are comprehensively determined, the nozzle is set according to a determined setting manner, and lubricating oil is sprayed to the milling area by utilizing the nozzle.

Abstract: The disclosure provides a method and system for milling injected cutting fluid under different working conditions. By analyzing influence of airflow fields in a milling area under different working conditions on injection of cutting fluid, an influence rule of a helical angle and a rotation speed of a cutter on the flow field is quantitatively analyzed, an optimal target distance of a nozzle, an angle between the nozzle and a milling cutter feeding direction and an angle between the nozzle and the surface of a workpiece are comprehensively determined, the nozzle is set according to a determined setting manner, and lubricating oil is sprayed to the milling area by utilizing the nozzle.

Abstract: The present disclosure provides a multi-path combined high-low voltage plasma rock-breaking drill bit, drill bit apparatus and drilling method. The multi-path combined high-low voltage plasma rock-breaking drill bit comprises: a drill bit body, insulators, plasma generators, drilling fluid outlets, plasma integrated pipelines, a drilling fluid pipe; wherein a plurality of plasma generators are distributed on the same drill bit body; the axis of the plasma generator and the axis of the drill bit body form a certain included angle; each of the plasma generators is independently connected to the ground through its respective plasma integrated pipeline and operates independently; and drilling fluid flows out of the drilling fluid outlets, takes away the heat generated by the operation of the plasma generators, thereby cooling the plasma generators.

Abstract: Disclosed is a method for prophylaxis or treatment of infection of a virus, or for modulating innate immunity, in a subject comprising administering to the subject a therapeutically effective amount of a PUM1 inhibitor. A pharmaceutical composition comprising the PUM1 inhibitor is also disclosed.

Abstract: The present disclosure belongs to the field of petroleum engineering, in particular to a fully-electrically driven downhole safety valve. The fully-electrically driven downhole safety valve comprises a downhole safety valve mechanism and a downhole safety valve control system; wherein the downhole safety valve mechanism includes an electronic cabin module, a transmission control module, a motion conversion module, a magnetic coupling and spring module. and a valve module; the downhole safety valve control system includes a downhole comprehensive unit and an uphole comprehensive unit.