Patents by Inventor Yonghua Gai

Yonghua Gai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinoxalinyl tripeptide hepatitis C virus inhibitors
    Publication number: 20080032936
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: August 4, 2006
    Publication date: February 7, 2008
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Yonghua Gai, Deqiang Niu, Yat Sun Or, Zhe Wang
  • MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS
    Publication number: 20080008681
    Abstract: The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 10, 2008
    Inventors: Deqiang Niu, Dong Liu, Joel Moore, Guoyou Xu, Ying Sun, Yonghua Gai, Datong Tang, Yat Sun Or, Zhe Wang
  • Quinoxalinyl Macrocyclic Hepatitis C Virus Serine Protease Inhibitors
    Publication number: 20070299078
    Abstract: The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: June 26, 2007
    Publication date: December 27, 2007
    Inventors: Deqiang Niu, Dong Liu, Joel Moore, Guoyou Xu, Ying Sun, Yonghua Gai, Datong Tang, Yat Or, Zhe Wang
  • Tetracyclic bicyclolides
    Patent number: 7312201
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: December 25, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Yat Sun Or, Zhe Wang
  • ?-(N-sulfonamido)acetamide derivatives as ?-amyloid inhibitors
    Patent number: 7300936
    Abstract: There is provided a series of novel ?-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of ?-amyloid peptide (?-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 27, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael F. Parker, Katharin E. McElhone, Robert A. Mate, Joanne J. Bronson, Yonghua Gai, Carl P. Bergstrom, Lawrence R. Marcin, John E. Macor
  • 11,12-lactone bicyclolides
    Patent number: 7291602
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: November 6, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Zhigang Chen, Yat Sun Or, Zhe Wang
  • Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
    Publication number: 20070207972
    Abstract: The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivative known as EDP-182 (IX-a).
    Type: Application
    Filed: January 23, 2007
    Publication date: September 6, 2007
    Inventors: Guoyou Xu, Yonghua Gai, Guoqlang Wang, Yat Sun Or, Zhe Wang
  • 3,6-Bicyclolides
    Patent number: 7229972
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: June 12, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yat Sun Or, Datong Tang, Yonghua Gai, Ying Sun, Guoyou Xu, Zhe Wang
  • Spirocyclic bicyclolides
    Publication number: 20060252713
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: May 3, 2006
    Publication date: November 9, 2006
    Inventors: Yonghua Gai, Datong Tang, Ying Sun, Zhigang Chen, Yat Or, Zhe Wang
  • 11,12-Lactone bicyclolides
    Publication number: 20060148731
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Zhigang Chen, Yat Or, Zhe Wang
  • Tetracyclic bicyclolides
    Publication number: 20060142215
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Yat Or, Zhe Wang
  • 3,6-bicyclolides
    Publication number: 20060142214
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: June 29, 2006
    Inventors: Yat Or, Datong Tang, Ying Sun, Yonghua Gai, Guoyou Xu, Zhe Wang
  • 3,6-Bicyclolides
    Publication number: 20060122128
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 7, 2004
    Publication date: June 8, 2006
    Inventors: Yat Or, Datong Tang, Yonghua Gai, Ying Sun, Guoyou Xu, Zhe Wang
  • Processes for the preparation of 6-11 bicyclic erythromycin derivatives
    Publication number: 20060058248
    Abstract: The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives.
    Type: Application
    Filed: October 25, 2005
    Publication date: March 16, 2006
    Inventors: Guoyou Xu, Datong Tang, Yonghua Gai, Heejin Kim, Guoqiang Wang, Ly Phan, Yat Or, Zhe Wang
  • Polymorphic forms of 6-11 bicyclic ketolide derivatives
    Publication number: 20050203035
    Abstract: The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
    Type: Application
    Filed: February 14, 2005
    Publication date: September 15, 2005
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Or, Hui-Yin Li
  • Processes for the preparation of 6-11 bicyclic erythromycin derivatives
    Publication number: 20040171818
    Abstract: The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives.
    Type: Application
    Filed: January 14, 2004
    Publication date: September 2, 2004
    Inventors: Guoyou Xu, Datong Tang, Yonghua Gai, Heejin Kim, Guoqiang Wang, Ly Tam Phan, Yat Sun Or, Zhe Wang
  • Alpha-(N-sulfonamido)acetamide derivatives as beta-amyloid inhibitors
    Publication number: 20040127494
    Abstract: There is provided a series of novel &agr;-(N-sulfonamido)acetamide compounds of the Formula (I) 1
    Type: Application
    Filed: December 20, 2002
    Publication date: July 1, 2004
    Inventors: Michael F. Parker, Katharine E. McElhone, Robert A. Mate, Joanne J. Bronson, Yonghua Gai, Carl P. Bergstrom, Lawrence R. Marcin, John E. Macor
  • Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors
    Patent number: 6492550
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: December 10, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
  • Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors
    Patent number: 6414179
    Abstract: Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Ra and Rb are as defined in the specification.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jacques Banville, Anne Marinier, Yonghua Gai, Serge Plamondon, Stephan Roy, Neelakantan Balasubramanian
  • Alpha-substituted thio,-oxo trifluoromethylketones as phospholipase inhibitors
    Publication number: 20020068722
    Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases.
    Type: Application
    Filed: February 8, 2001
    Publication date: June 6, 2002
    Inventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian