Abstract: Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjutant.

Abstract: Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.

Abstract: Provided in the present invention is the use of a mevalonic acid pathway inhibitor in the preparation of a drug for treating and/or preventing tumours, inducing immunogenic death of tumour cells, inducing immune responses and activating T cells or DC cells to directly promote host immunity. Also provided in the present invention is a pharmaceutical composition comprising the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and a combination of the mevalonic acid pathway inhibitor and an antitumour drug (for example, an immune checkpoint inhibitor and any drug that can lead to new antigen production) and/or the radiotherapy.

Abstract: Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate to pathway as an adjuvant.

Abstract: A trailer dolly can include various features to be adjustable between a manual configuration and a vehicular towing configuration. In the manual configuration, a user can manually maneuver the trailer dolly to position the trailer, such as by using one or more retractable handles. Where the user desires to maneuver the trailer with a vehicle, the trailer dolly can be adjusted to the vehicle towing configuration. In an example, the trailer dolly can be coupled to the vehicle with a second hitch attached to the trailer dolly, the second hitch located distally along the tow bar with respect to the trailer hitch supporting the trailer load. Accordingly, the trailer dolly can be used for both manual and vehicular applications and the user can transition between the manual and vehicular configurations while the trailer is hitched to the trailer dolly.

Abstract: A trailer dolly can include various features to be adjustable between a manual configuration and a vehicular towing configuration. In the manual configuration, a user can manually maneuver the trailer dolly to position the trailer, such as by using one or more retractable handles. Where the user desires to maneuver the trailer with a vehicle, the trailer dolly can be adjusted to the vehicle towing configuration. In an example, the trailer dolly can be coupled to the vehicle with a second hitch attached to the trailer dolly, the second hitch located distally along the tow bar with respect to the trailer hitch supporting the trailer load. Accordingly, the trailer dolly can be used for both manual and vehicular applications and the user can transition between the manual and vehicular configurations while the trailer is hitched to the trailer dolly.

Abstract: The present invention discloses a centralized power supply shielding structure of a cabinet-level server, where the structure includes multiple plug-in frames, a power supply copper bar which is configured to supply power to the multiple plug-in frames, and an inner container shielding can. Multiple plugs of the power supply copper bar are correspondingly inserted into the multiple plug-in frames to supply power to the multiple plug-in frames in a centralized way. The inner container shielding can wraps on a periphery of the power supply copper bar to shield the multiple plug-in frames from the power supply copper bar. The cabinet-level server and its centralized power supply shielding structure of the present invention implement a shielding structure for centralized power supply by a copper bar of integration of a frame and a cabinet, which can be applied in an application scene of an open rack and has a simple structural design.