Abstract: The present disclosure proposes a type of three-dimensional eyeglasses, including a polarizer and a first wave plate on one side of the polarizer, the first wave plate is a quarter-wavelength wave plate and includes a first left lens and a first right lens corresponding to the left eye and the right eye of a user respectively, the optical axis of the first left lens is vertical to that of the first right lens, and the angles formed between the direction of the transmission axis of the polarizer and those of the optical axes of the first left lens and the first right lens are both 45 degrees, wherein, a second wave plate is arranged on the side of the polarizer away from the first wave plate, the light from a screen passes through the first wave plate, the polarizer and the second wave plate and is then emitted, and the second wave plate is arranged in such a manner that the light emitted after passing through the three-dimensional eyeglasses is circularly polarized light.

Abstract: This document provides methods and materials related to determining whether or not a mammal (e.g., a human) has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or amyotrophic lateral sclerosis (ALS)). For example, methods and materials for using the levels of TDP-43 polypeptides and/or TDP-43 polypeptide cleavage products (e.g., 25 kD and 35 kD TDP-43 polypeptide cleavage products) in a biological fluid (e.g., cerebrospinal fluid) to determine whether or not a mammal has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or ALS) are provided.