Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX??(I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X??(II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

Abstract: An apparatus includes a storage medium, and a transducer positioned adjacent to the storage medium, wherein the transducer includes a first electrode and a second electrode, with the width of the first electrode being less than the width of the second electrode. A method including: applying a first voltage to a transducer to write data to a storage medium, and applying a second voltage to the transducer to read data from the storage medium, wherein the magnitude of the first voltage is greater than the magnitude of the second voltage.

Abstract: Novel compounds of formula (I): suitable for use as in vivo imaging agents are provided as well as precursors suitable for the preparation of said compounds. The present invention also provides pharmaceuticals comprising the compounds and kits for the preparation of the pharmaceuticals. Furthermore, use of the compounds for imaging peripheral benzodiazepine receptors in a subject is provided, in particular for imaging pathological conditions in which PBR are upregulated, e.g. Parkinson's disease, multiple sclerosis, Alzheimer's disease and Huntington's disease, neuropathic pain, arthritis, asthma, atherosclerosis and cancer.

Abstract: An apparatus includes a storage medium, a transducer positioned adjacent to the storage medium and along an axis, and first and second support members connected to the transducer at positions that are spaced apart in the direction of the axis.

Abstract: An apparatus includes a storage medium, and a transducer positioned adjacent to the storage medium, wherein the transducer includes a first electrode and a second electrode, with the width of the first electrode being less than the width of the second electrode. A method including: applying a first voltage to a transducer to write data to a storage medium, and applying a second voltage to the transducer to read data from the storage medium, wherein the magnitude of the first voltage is greater than the magnitude of the second voltage.

Abstract: The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R?, R?, and R?? are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R? may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.

Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX??(I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X??(II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

Abstract: A process for fabricating a polymer based circuit by the following steps. A mold of a design is formed through a lithography process. The design is transferred to a polymer substrate through a hot embossing process. A metal layer is then deposited over at least part of said design and at least one electrical lead is connected to said metal layer.

Abstract: The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R?, R?, and R?? are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R? may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.

Abstract: The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F? to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)nX (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F?, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

Abstract: The present invention includes a device comprising a plurality of interconnected computers. Each of the plurality of interconnected computers preferably includes a storage device that is configured to store a cookie entry when the computer user visits a web page. The cookie entry preferably comprises a path name, a description of web page content, and a uniform resource locator of the web page. The device further includes at least one processor in communication with the plurality of interconnected computers. The processor is preferably configured to accept a search query from a computer user, compare the search query with the cookie entry, and provide the computer user with the uniform resource locator of the cookie entry that match the search query.

Abstract: The present invention includes a method of composing at least one literary work. The method includes establishing a story theme; providing a plurality of interconnected computers; allowing users to use the plurality of interconnected computers; forming a cast of authors from the users of the plurality of interconnected computers; and allowing the cast of authors to compose a script based on the story theme.

Abstract: Methods and apparatuses for facilitating online communications are described. One method comprises allowing at least one message author to compose a message; allowing the message author to provide a description of the message; defining a plurality of message types, each type distinguishable by its message description; associating the author's message with a message type from the plurality of defined message types; allowing at least one potential message recipient to enter a profile, the profile comprising an indication of the type of message the potential message recipient desires to receive; and, associating the author's message with at least one potential message recipient profile based on the message type.