Patents by Inventor Yongku Peter Cho

Yongku Peter Cho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TARGETING GLIOBLASTOMA STEM-LIKE CELLS AND METHODS OF USE THEREOF
    Publication number: 20240018263
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Application
    Filed: September 7, 2023
    Publication date: January 18, 2024
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • Antibodies targeting glioblastoma stem-like cells and methods of use thereof
    Patent number: 11780932
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: October 10, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20220169684
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: February 10, 2022
    Publication date: June 2, 2022
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Channelrhodopsins for optical control of cells
    Patent number: 11274128
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 15, 2022
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Channelrhodopsin variants and uses thereof
    Patent number: 10882892
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 5, 2021
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • ANTIBODIES TARGETING GLIOBLASTOMA STEM-LIKE CELLS AND METHODS OF USE THEREOF
    Publication number: 20200354472
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Application
    Filed: October 9, 2018
    Publication date: November 12, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20200291074
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Channelrhodopsins for optical control of cells
    Patent number: 10717769
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: July 21, 2020
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane KA-Shu Wong, Yongku Peter Cho
  • Channelrhodopsins for optical control of cells
    Patent number: 10711044
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: July 14, 2020
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Mutant channelrhodopsins with altered ion selectivity
    Patent number: 10590181
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.
    Type: Grant
    Filed: April 18, 2015
    Date of Patent: March 17, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward S. Boyden, Yongku Peter Cho, Nathan C. Klapoetke, Amy S. Chuong, Fei Chen
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20200031883
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 30, 2020
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20190352347
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Channelrhodopsins for optical control of cells
    Patent number: 10472399
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Channelrhodopsins for optical control of cells
    Patent number: 10472398
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20170088590
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 30, 2017
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • MUTANT CHANNELRHODOPSINS WITH ALTERED ION SELECTIVITY
    Publication number: 20160176933
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.
    Type: Application
    Filed: April 18, 2015
    Publication date: June 23, 2016
    Applicant: MASSUCHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Edward S. Boyden, Yongku Peter Cho, Nathan C. Klapoetke, Amy S. Chuong, Fei Chen
  • CHANNELRHODOPSIN VARIANTS AND USES THEREOF
    Publication number: 20160039902
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 11, 2016
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS
    Publication number: 20140324134
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: November 12, 2012
    Publication date: October 30, 2014
    Applicants: Massachusetts Institute of Technology, The Governrs of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • BLOOD-BRAIN BARRIER TARGETING ANTIBODIES
    Publication number: 20110262460
    Abstract: This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies.
    Type: Application
    Filed: June 9, 2011
    Publication date: October 27, 2011
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Eric V. Shusta, Xin Xiang Wang, Yongku Peter Cho
  • Blood-brain barrier targeting anti-bodies
    Patent number: 7981417
    Abstract: This invention provides antibodies that bind brain endothelial cell receptors resulting in endocytosis/transcytosis of the receptor and bound ligands. In some embodiments, the ligand comprises the antibody in combination with a pharmaceutically active compound and the antibody directs delivery of the compound across the blood brain barrier (BBB). The invention also provides methods of identifying endothelial cell specific antibodies by panning the library against cultured cell monolayers. The invention further allows for identifying endothelial cell receptors that bind the antibody thereby providing target receptors against which to isolate further cognate ligands and their associated transport systems and by which to identify transcytosis transporters targeted by the antibodies.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: July 19, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric V. Shusta, Xin Xiang Wang, Yongku Peter Cho