Patents by Inventor Yongkuan ZHU

Yongkuan ZHU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NITROGEN-CONTAINING POLYCYCLIC FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20240174674
    Abstract: A nitrogen-containing polycyclic fused ring compound represented by formula I, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof are provided. The compound has an inhibitory effect on RET gatekeeper residue mutant RET V804M mutation, RET solvent front residue mutant G810R, and other clinically relevant RET mutants and RET-wt. The compound can also significantly inhibit the growth of a TT cell line derived from thyroid cancer and Ba/F3 cells transformed by various RET mutants, and has a stronger inhibition effect than selective RET inhibitor LOXO-292. In addition, the compound can block cellular RET autophosphorylation and downstream pathways, and can significantly induce TT cell death.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 30, 2024
    Inventors: Jun ZHONG, Yongkuan ZHU, Yongbo LIU, Xiaohu CHEN, Libin LIU, Minchun CHEN, Hao WANG, Qin GAO
  • FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
    Publication number: 20230060425
    Abstract: The invention relates to novel compounds of the formula (I) in which the Q, R1, Ra, Rb, Rc, Rd and n have the meanings given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.
    Type: Application
    Filed: February 24, 2020
    Publication date: March 2, 2023
    Inventors: Laura HOFFMEISTER, Ruediger FISCHER, Matthieu WILLOT, Dominik HAGER, Kerstin ILG, Marc LINKA, Ulrich GOERGENS, Peter LOESEL, Jing XIANG, Yongkuan ZHU, Andreas TURBERG