Patents by Inventor Yongkui Sun

Yongkui Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200352906
    Abstract: The use of EP4 receptor antagonist compounds represented by Formula (I) (or pharmaceutically acceptable salts thereof) as defined herein is provided for treating cancer or inflammatory disease by administering such an EP4 antagonist alone or in combination with an antibody therapy, radiation therapy, anti-metabolite chemotherapy to a subject in need thereof.
    Type: Application
    Filed: February 2, 2019
    Publication date: November 12, 2020
    Applicants: Shenzhen Ionova Life Science Co., Ltd., Foshan Ionova Biotherapeutics Co., Inc.
    Inventors: Gang Zhou, Yongkui Sun, Zhaoyin Wang
  • Patent number: 7976595
    Abstract: A method of gasification burner online feeding for a coal-water slurry gasifier, where a coal-water slurry line and an oxidizer line are both protected by shield gas. The method may realize online, pressurized and continuous feeding of the gasification burners which are fixed after they stalled for other reasons than their own, thus greatly reducing the probability of accidental shutdown of gasifiers and improving the reliability of long-term service of the multi-nozzle opposed gasifier.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: July 12, 2011
    Assignee: Yankuang Group Corporation Limited
    Inventors: Xin Wang, Minglin Zhang, Qingrui Zhu, Min Zhu, Jiyong Zhang, Xinfang Jiang, Yifei Zhang, Yongkui Sun, Mei Han, Weihua Zhang
  • Patent number: 7495123
    Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: February 24, 2009
    Assignees: Solvias AG, Merck & Co., Inc.
    Inventors: Yi Xiao, Yongkui Sun, Thorsten Rosner, Nelo R. Rivera, Shane W. Krska, Andrew M. Clausen, Joseph D. Armstrong, III, Felix Spindler, Christophe Malan
  • Patent number: 7468459
    Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: December 23, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Yi Xiao, Joseph D. Armstrong, III, Shane W. Krska, Eugenia Njolito, Nelo R. Rivera, Yongkui Sun, Thorsten Rosner
  • Publication number: 20080216406
    Abstract: A method of gasification burner online feeding for a coal-water slurry gasifier, where a coal-water slurry line and an oxidizer line are both protected by shield gas. The method may realize online, pressurized and continuous feeding of the gasification burners which are fixed after they stalled for other reasons than their own, thus greatly reducing the probability of accidental shutdown of gasifiers and improving the reliability of long-term service of the multi-nozzle opposed gasifier.
    Type: Application
    Filed: February 14, 2008
    Publication date: September 11, 2008
    Inventors: Xin Wang, Minglin Zhang, Qingrui Zhu, Min Zhu, Jiyong Zhang, Xinfang Jiang, Yifei Zhang, Yongkui Sun, Mei Han, Weihua Zhang
  • Publication number: 20080058522
    Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
    Type: Application
    Filed: April 5, 2005
    Publication date: March 6, 2008
    Inventors: Yi Xiao, Yongkui Sun, Thorsten Rosner, Nelo Rivera, Shane Krska, Andrew Clausen, Joseph Armstrong, Felix Spindler, Christophe Malan
  • Publication number: 20060194977
    Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
    Type: Application
    Filed: March 15, 2004
    Publication date: August 31, 2006
    Inventors: Yi Xiao, Joseph Armstrong III, Shane Krska, Eugenia Njolito, Nelo Rivera, Yongkui Sun, Thorsten Rosner
  • Patent number: 6835860
    Abstract: Iodohydroxylated olefins can be prepared by treating an olefin with an aqueous solution of an iodine monohalide selected from iodine monochloride and iodine monobromide.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: December 28, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Yongkui Sun, Thorsten Rosner
  • Publication number: 20030187291
    Abstract: Iodohydroxylated olefins can be prepared by treating an olefin with an aqueous solution of an iodine monohalide selected from iodine monochloride and iodine monobromide.
    Type: Application
    Filed: January 31, 2003
    Publication date: October 2, 2003
    Inventors: Yongkui Sun, Thorsten Rosner
  • Patent number: 6603013
    Abstract: The present invention relates to a process wherein heterogeneous finely-dispersed palladium catalysts are used in a cross-coupling reaction of alkenyl halides and aryl or heteroaryl boronic acids in the presence of base in an aprotic solvent to produce aryl- or heteroaryl-olefin compounds of Formula I:
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: August 5, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Yongkui Sun, Carl LeBlond, John R. Sowa, Jr.
  • Publication number: 20020128478
    Abstract: This invention relates to a process for the Heck coupling reaction where heterogeneous palladium catalysts are used to activate aryl halides for a carbon-carbon coupling with olefins in the presence a base and an aprotic solvent to produce aryl-olefin compounds. The process, in particular, provides for the use of aryl chlorides substituted with electron-withdrawing or electron-donating group for the cross coupling with olefins.
    Type: Application
    Filed: March 4, 2002
    Publication date: September 12, 2002
    Inventors: Shane W. Krska, Thorsten S. Rosner, Yongkui Sun
  • Publication number: 20020045775
    Abstract: The present invention relates to a process wherein heterogeneous finely dispersed palladium catalysts are used for cross coupling of alkenyl halides and boronic acids in the presence of base in an aprotic solvent to produce aryl- or heteroaryl-olefin compounds. The process provides for use with either electron-withdrawing or electron-donating substituents for cross coupling of alkyl halides with boronic acids.
    Type: Application
    Filed: July 16, 2001
    Publication date: April 18, 2002
    Inventors: Yongkui Sun, Carl LeBlond, John R. Sowa
  • Publication number: 20020016512
    Abstract: This invention relates to a ligandless process wherein heterogeneous Pd catalysts are used to activate aryl and heteroaryl chlorides for cross coupling aryl and heteroaryl chlorides and boronic acids. The process provides for use with either electron-withdrawing or electron-donating substituents, for cross coupling with boronic acids.
    Type: Application
    Filed: July 16, 2001
    Publication date: February 7, 2002
    Inventors: Yongkui Sun, Carl LeBlond, John R. Sowa
  • Patent number: 6025500
    Abstract: The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, enalapril.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: February 15, 2000
    Assignee: Merck & Co., Ltd.
    Inventors: Mark A. Huffman, Paul J. Reider, Carl Leblond, Yongkui Sun