Abstract: A silane functionalized block copolymer (SiHSBC) is disclosed comprising: 80 to 99.90 wt. % of a hydrogenated styrenic block copolymer (HSBC) and 0.1 to 20 wt. % of a silane, based on the total weight of the SiHSBC. The HSBC is obtained by hydrogenation of a styrenic block copolymer (SBC) comprising at least one polymer block A derived from a vinyl aromatic monomer, and at least one polymer block B derived from a conjugated diene monomer. The polymer block B has greater than 80 wt. % of a polymerized 1,3-butadiene monomer, based on the total weight of the polymerized conjugated diene monomer in the polymer block B. The SiHSBC as well as thermoplastic elastomer composition containing the SiHSBC show improved adhesion to polar and non-polar substrates without the need of an adhesive layer or primer layer.

Abstract: The present invention provides pharmaceutically acceptable salts of compounds of Formula I that are potent EP4 receptor antagonists and can be used for treating cancer or inflammatory diseases alone or in combination with antibody therapy, radiation therapy, anti-metabolite chemotherapy to a subject in need thereof.

Abstract: The use of EP4 receptor antagonist compounds represented by Formula (I) (or pharmaceutically acceptable salts thereof) as defined herein is provided for treating cancer or inflammatory disease by administering such an EP4 antagonist alone or in combination with an antibody therapy, radiation therapy, anti-metabolite chemotherapy to a subject in need thereof.

Abstract: A method of gasification burner online feeding for a coal-water slurry gasifier, where a coal-water slurry line and an oxidizer line are both protected by shield gas. The method may realize online, pressurized and continuous feeding of the gasification burners which are fixed after they stalled for other reasons than their own, thus greatly reducing the probability of accidental shutdown of gasifiers and improving the reliability of long-term service of the multi-nozzle opposed gasifier.

Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.

Abstract: A method of gasification burner online feeding for a coal-water slurry gasifier, where a coal-water slurry line and an oxidizer line are both protected by shield gas. The method may realize online, pressurized and continuous feeding of the gasification burners which are fixed after they stalled for other reasons than their own, thus greatly reducing the probability of accidental shutdown of gasifiers and improving the reliability of long-term service of the multi-nozzle opposed gasifier.

Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.

Abstract: Iodohydroxylated olefins can be prepared by treating an olefin with an aqueous solution of an iodine monohalide selected from iodine monochloride and iodine monobromide.

Abstract: Iodohydroxylated olefins can be prepared by treating an olefin with an aqueous solution of an iodine monohalide selected from iodine monochloride and iodine monobromide.

Abstract: The present invention relates to a process wherein heterogeneous finely-dispersed palladium catalysts are used in a cross-coupling reaction of alkenyl halides and aryl or heteroaryl boronic acids in the presence of base in an aprotic solvent to produce aryl- or heteroaryl-olefin compounds of Formula I:

Abstract: This invention relates to a process for the Heck coupling reaction where heterogeneous palladium catalysts are used to activate aryl halides for a carbon-carbon coupling with olefins in the presence a base and an aprotic solvent to produce aryl-olefin compounds. The process, in particular, provides for the use of aryl chlorides substituted with electron-withdrawing or electron-donating group for the cross coupling with olefins.

Abstract: The present invention relates to a process wherein heterogeneous finely dispersed palladium catalysts are used for cross coupling of alkenyl halides and boronic acids in the presence of base in an aprotic solvent to produce aryl- or heteroaryl-olefin compounds. The process provides for use with either electron-withdrawing or electron-donating substituents for cross coupling of alkyl halides with boronic acids.

Abstract: This invention relates to a ligandless process wherein heterogeneous Pd catalysts are used to activate aryl and heteroaryl chlorides for cross coupling aryl and heteroaryl chlorides and boronic acids. The process provides for use with either electron-withdrawing or electron-donating substituents, for cross coupling with boronic acids.

Abstract: The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, enalapril.