Patents by Inventor Yongkun YANG

Yongkun YANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY AND CHIMERIC ANTIGEN RECEPTOR (CAR) BINDING TO CD70, AND APPLICATION THEREOF
    Publication number: 20230399412
    Abstract: A CD70 antibody and a chimeric antigen receptor (CAR) that can specifically bind to a CD70 protein. The CAR comprises a CD70 binding domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. Further disclosed is an application of the antibody and the CAR for treating diseases or conditions related to CD70 expression.
    Type: Application
    Filed: October 12, 2021
    Publication date: December 14, 2023
    Applicant: Nanjing IASO Biotechnology Co., Ltd.
    Inventors: Yongkun Yang, Guang Hu, Panpan Niu, Guangrong Meng, Jialu Mo, Jianhua Zhang, Qianli Hu, Wei Cheng, Taochao Tan, Qiaoe Wei, Xiangyin Jia, Zhenyu Dai
  • FULLY HUMANIZED BISPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING CD19 AND CD22 AND USE THEREOF
    Publication number: 20230241212
    Abstract: Provided is a bispecific chimeric antigen receptor targeting CD19 and CD22, which comprises extracellular antigen binding domains of heavy-chain variable regions and light-chain variable regions of anti-CD19 and anti-CD22 antibodies. Further provided is a bispecific CAR-T cell targeting CD19 and CD22.
    Type: Application
    Filed: June 30, 2021
    Publication date: August 3, 2023
    Applicant: Nanjing IASO Biotherapeutics Co., Ltd.
    Inventors: Yongkun Yang, Guang Hu, Taochao Tan, Zhenyu Dai, Panpan Niu, Guangrong Meng, Wei Cheng, Xiangyin Jia, Jialu Mo, Wen Wang, Bailu Xie, Junfeng Yang, Fei Zhou
  • FULLY HUMAN ANTI-HUMAN CD22 CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF
    Publication number: 20230174654
    Abstract: The present invention provides an anti-CD22 antibody molecule and a CD22-targeted chimeric antigen receptor (CAR) constructed using the anti-CD22 antibody molecule. The present invention also provides an application of the anti-CD22 antibody molecule and the CAR in the preparation of drugs for treating CD22-related diseases.
    Type: Application
    Filed: April 2, 2021
    Publication date: June 8, 2023
    Applicant: Nanjing IASO Biotherapeutics Co., Ltd.
    Inventors: Guang Hu, Yongkun Yang, Panpan Niu, Guangrong Meng, Wei Cheng, Jialu Mo
  • FULLY HUMAN ANTIBODY TARGETING CD19 AND APPLICATION THEREOF
    Publication number: 20220220200
    Abstract: Provided are a fully human antibody targeting CD19 or a single chain antibody or fragment thereof. Further provided is a chimeric antigen receptor (CAR) constructed by using a single chain antibody (scFv) derived from the fully human antibody. The fully human antibody and the CAR can be used for the construction of CAR-T cells targeting CD19. Compared with CAR-T cells using murine antibodies, the CAR-T cells have better compatibility with the human body, which is beneficial to their long-term proliferation and survival in the body.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 14, 2022
    Applicant: NANJING IASO BIOTHERAPEUTICS CO., LTD.
    Inventors: Taochao Tan, Zhenyu Dai, Xiangyin Jia, Qiaoe Wei, Yongkun Yang
  • Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
    Patent number: 11266690
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 8, 2022
    Assignees: Nanjing IASO Biotherapeutics Co., Ltd., Innovent Biologics (Suzhou) Co., Ltd.
    Inventors: Jianfeng Zhou, Junjian Liu, Guang Hu, Yongkun Yang, Guangrong Meng, Wenjing Gao, Yuyu Wang, Panpan Niu
  • Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
    Patent number: 11026975
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: June 8, 2021
    Assignees: Nanjing IASO Biotherapeutics Co., Ltd., Innovent Biologics (Suzhou) Co., Ltd.
    Inventors: Jianfeng Zhou, Junjian Liu, Guang Hu, Yongkun Yang, Guangrong Meng, Wenjing Gao, Yuyu Wang, Panpan Niu
  • CHIMERIC ANTIGEN RECEPTOR (CAR) BINDING TO BCMA, AND USES THEREOF
    Publication number: 20200376030
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Application
    Filed: January 31, 2019
    Publication date: December 3, 2020
    Inventors: Jianfeng ZHOU, Junjian LIU, Guang HU, Yongkun YANG, Guangrong MENG, Wenjing GAO, Yuyu WANG, Panpan NIU
  • CHIMERIC ANTIGEN RECEPTOR (CAR) BINDING TO BCMA, AND USES THEREOF
    Publication number: 20200246381
    Abstract: The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 6, 2020
    Inventors: Jianfeng ZHOU, Junjian LIU, Guang HU, Yongkun YANG, Guangrong MENG, Wenjing GAO, Yuyu WANG, Panpan NIU