Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of KRas. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the KRas inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia, lung cancer, colorectal cancer, pancreatic cancer, and other diseases or conditions dependent on KRas interaction.

Abstract: A vibratory grouting drilling rig includes: a drilling rig bracket, a moving bracket, and a driving mechanism mounted on the drilling rig bracket for driving the moving bracket to move; wherein a working bracket is slidingly mounted on the moving bracket, and a sliding direction of the working bracket is identical to a moving direction of the moving bracket; a vibratory grouting rod and a drilling rod are mounted on the working bracket; multiple flexible connectors are connected between the working bracket and the drilling rig bracket, and are arranged along the moving direction of the moving bracket; the flexible connectors go around an end of the moving bracket and are connected to the drilling rig bracket. When the moving bracket moves, the flexible connectors pull the working bracket to move relative to the moving bracket, thus providing extra drilling force.

Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.

Abstract: This application relates to a protective apparatus. The protective apparatus is configured to protect a to-be-welded part, the to-be-welded part includes a welding region, and the protective apparatus includes a base and a protective mechanism. The base is configured for embedding the to-be-welded part. The protective mechanism is connected to the base. The protective mechanism includes a welding hole, where the welding hole is provided corresponding to the welding region; and a surface of the protective mechanism facing the welding hole is provided with a thermally conductive coating, where the thermally conductive coating is configured to guide substances formed in welding the to-be-welded part to slide down along the surface of the thermally conductive coating. The protective apparatus in this application can improve welding quality of the welding region, thereby enhancing performance of the to-be-welded part.

Abstract: The present disclosure provides a grid system, including a grid body and supports, where the grid body includes a water intake module, a filtering module, a residue scraping module, a residue pressing module, and a water discharge module; the filtering module is disposed at a middle-upper part of the grid body, the water intake module and the residue pressing module are organically coupled at a lower part of the filtering module, and the water intake module includes a water inlet and a water distribution area; the filtering module includes a water retaining platform, an inflow water guide plate, screen plate areas, and a central water retaining weir; the residue scraping module includes scrapers, a driving motor, a support frame, a residue inlet, and a guide rail; the residue pressing module includes a squeezing cylinder, a motor, and a residue outlet.

Abstract: An electrode plate conveying mechanism includes: a first conveying roller used for conveying an electrode plate; and a negative pressure supply unit arranged on at least one end of the first conveying roller, spaced apart from the first conveying roller in an axial direction of the first conveying roller, and used for forming a negative pressure around a tab of the electrode plate so as to prevent the tab from being folded.

Abstract: Disclosed is a compound of formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a co-crystal or a deuterated product thereof, or a pharmaceutical composition containing same, and the use thereof as a CD73 antagonist in the preparation of a drug for treating related diseases, wherein the definition of each group in formula (I) is consistent with the definition in the description.

Abstract: This application provides example variable gain amplifiers and example phased array transceivers. One example variable gain amplifier includes an amplification circuit, configured to amplify an input signal; a control circuit, configured to control a gain of the amplification circuit by adjusting an output current of the amplification circuit; an inductive load, where the inductive load is coupled to a signal output end of the amplification circuit; and an inductive adjustment circuit, where the inductive adjustment circuit and the inductive load are inductively coupled, and where the inductive adjustment circuit is adjustable.

Abstract: Embodiments are directed to a substantially linear luminaire assembly which includes an elongated translucent or transparent housing, where the housing comprises a first end and a second end. One or more light sources may be at least partially enclosed by the elongated housing. A detachable lens assembly may be affixed at or near at least one of the first end and the second end. The detachable lens assembly may include one or more lenses improve a uniformity of light ray distribution of light rays emitted by the one or more light sources.

Abstract: A switch circuit, a mixer, and an electronic device, where the switch circuit includes a first metal oxide semiconductor (MOS) transistor, a second MOS transistor, a third MOS transistor, and a fourth MOS transistor, both a gate of the first MOS transistor and a gate of the fourth MOS transistor are connected to a first port, and both a gate of the second MOS transistor and a gate of the third MOS transistor are connected to a second port; and a lead between the gate of the first MOS transistor and the first port, a lead between the gate of the second MOS transistor and the second port, a lead between the gate of the third MOS transistor and the second port, and a lead between the gate of the fourth MOS transistor and the first port all have an equal length. In this way, linearity is relatively high.

Abstract: A product identification method comprises instructing an antenna in a product verification area to collect first product identification data of identified products in the case where a user enters the product verification area of a product identification passage; instructing the antenna in the product verification area to collect product verification data of identified products in the case where a user enters a product settlement area of the product identification passage; and determining user product data based on the first product identification data and the product verification data. A product verification area is provided to eliminate a tag outside the passage being falsely read and reduce a tag false reading probability.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A thienopyrimidine compound (a compound of formula N) and a preparation method therefor are provided. Specifically, the preparation method includes the steps of: (a) in a solvent A, reacting, in the presence of an organic base and acyl chloride, a compound of formula N-2 with 3-amino-6-methoxypyridazine to obtain a compound of formula N-1; and (b) in a solvent B, converting, in the presence of a base, the compound of formula N-1 into the compound of formula N. The preparation method does not require toxic and expensive reagents, has mild reaction conditions and a high product purity, and is suitable for industrial production.

Abstract: This technology comprises a combined accessory of an in-situ concrete 3-D printed horizontal load-bearing member and a preparation method. The combined accessory includes 3-D printed concrete and a bottom mesh, the 3-D printed concrete contains fine aggregates having the particle size of 0.08 mm-4.75 mm, and the fluidity of the 3-D printed concrete is larger than or equal to 110 mm and smaller than or equal to 190 mm; the bottom mesh is a reinforcing mesh or expanded metal, the diameter of the reinforcing bar is larger than or equal to 0.5 mm, and the mesh aperture of the reinforcing mesh is smaller than or equal to 7.5 times of an upper limit of the particle size of the fine aggregate and is larger than or equal to 7.5 times of a lower limit of the particle size of the fine aggregate.

Abstract: A probe includes a fast-scanning cyclic voltammetry electrode, a conductive wall disposed around the fast-scanning cyclic voltammetry electrode, and a wire in electronic communication with the fast-scanning cyclic voltammetry electrode. The conductive wall is grounded. Fast scanning cyclic voltammetry electrode currents are enclosed within the conductive wall. Resulting fast scanning cyclic voltammetry can have sub-?V level artifacts.

Abstract: Disclosed are a dedusting apparatus, a battery manufacturing device, and a dedusting method. The dedusting apparatus is used for removing dust on the surface of a material belt, and includes a dust suction mechanism and a magnetic mechanism, wherein the magnetic mechanism is arranged opposite to the dust suction mechanism at an interval to form a gap for the material belt to pass through, and the magnetic mechanism is used for generating an alternating magnetic field. By arranging the magnetic mechanism and the dust suction mechanism opposite to each other on both sides of the material belt in the thickness direction, when the material belt passes through the gap between the magnetic mechanism and the dust suction mechanism, metal dust passing through the gap along with the material belt is affected by the alternating magnetic field and induced to form an eddy current.

Abstract: A whispering gallery mode resonator based on a cylindrical cavity in an optical fiber and a fabrication method thereof are disclosed, which belong to the technical field of optical fiber application. The whispering gallery mode resonator includes an optical fiber body, a cylindrical cavity is provided in the optical fiber body, a top end of the cylindrical cavity is i open, and a bottom end of the cylindrical cavity is located inside the optical fiber body. Part or all of the cylindrical cavity blocks a part of transmitted beam of the optical fiber body, such that the part of the transmitted beam of the optical fiber body is coupled to an inner wall of the cylindrical cavity in a tangential direction, and then periodically propagates on the inner wall of the cylindrical cavity to form a whispering gallery mode.