Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A thienopyrimidine compound (a compound of formula N) and a preparation method therefor are provided. Specifically, the preparation method includes the steps of: (a) in a solvent A, reacting, in the presence of an organic base and acyl chloride, a compound of formula N-2 with 3-amino-6-methoxypyridazine to obtain a compound of formula N-1; and (b) in a solvent B, converting, in the presence of a base, the compound of formula N-1 into the compound of formula N. The preparation method does not require toxic and expensive reagents, has mild reaction conditions and a high product purity, and is suitable for industrial production.

Abstract: This technology comprises a combined accessory of an in-situ concrete 3-D printed horizontal load-bearing member and a preparation method. The combined accessory includes 3-D printed concrete and a bottom mesh, the 3-D printed concrete contains fine aggregates having the particle size of 0.08 mm-4.75 mm, and the fluidity of the 3-D printed concrete is larger than or equal to 110 mm and smaller than or equal to 190 mm; the bottom mesh is a reinforcing mesh or expanded metal, the diameter of the reinforcing bar is larger than or equal to 0.5 mm, and the mesh aperture of the reinforcing mesh is smaller than or equal to 7.5 times of an upper limit of the particle size of the fine aggregate and is larger than or equal to 7.5 times of a lower limit of the particle size of the fine aggregate.

Abstract: A probe includes a fast-scanning cyclic voltammetry electrode, a conductive wall disposed around the fast-scanning cyclic voltammetry electrode, and a wire in electronic communication with the fast-scanning cyclic voltammetry electrode. The conductive wall is grounded. Fast scanning cyclic voltammetry electrode currents are enclosed within the conductive wall. Resulting fast scanning cyclic voltammetry can have sub-?V level artifacts.

Abstract: Disclosed are a dedusting apparatus, a battery manufacturing device, and a dedusting method. The dedusting apparatus is used for removing dust on the surface of a material belt, and includes a dust suction mechanism and a magnetic mechanism, wherein the magnetic mechanism is arranged opposite to the dust suction mechanism at an interval to form a gap for the material belt to pass through, and the magnetic mechanism is used for generating an alternating magnetic field. By arranging the magnetic mechanism and the dust suction mechanism opposite to each other on both sides of the material belt in the thickness direction, when the material belt passes through the gap between the magnetic mechanism and the dust suction mechanism, metal dust passing through the gap along with the material belt is affected by the alternating magnetic field and induced to form an eddy current.

Abstract: A whispering gallery mode resonator based on a cylindrical cavity in an optical fiber and a fabrication method thereof are disclosed, which belong to the technical field of optical fiber application. The whispering gallery mode resonator includes an optical fiber body, a cylindrical cavity is provided in the optical fiber body, a top end of the cylindrical cavity is i open, and a bottom end of the cylindrical cavity is located inside the optical fiber body. Part or all of the cylindrical cavity blocks a part of transmitted beam of the optical fiber body, such that the part of the transmitted beam of the optical fiber body is coupled to an inner wall of the cylindrical cavity in a tangential direction, and then periodically propagates on the inner wall of the cylindrical cavity to form a whispering gallery mode.

Abstract: Embodiments are directed to a horticultural luminaire and method for assembling the horticultural luminaire. The horticultural luminaire may include a center body having a top surface and a bottom surface and comprising three or more items of material. A driver may be coupled to each of the items of material. The horticultural luminaire may also include a plurality of arms onto which lighting units are mounted. For each arm of the plurality of arms, a first end of the arm may be detachably coupled to a corresponding item of the three or more items of material. A corresponding driver may provide electrical power to light the lighting units on each arm.

Abstract: Disclosed is a medium to large-sized cable peeling device, including a main component having a base, a cable support positioned on top of the base and a positioning frame positioned in the middle of the cable support; and a cutting assembly positioned below the positioning frame and in the middle of the cable support, the cutting assembly has an adjustment component positioned below the positioning frame, a cutting blade positioned at the bottom of the adjustment component, a locking component positioned inside the cutting blade and a rotating component positioned below the adjustment component and in the middle of the cable support. The invention achieves adjustment of cable peeling based on the thickness of the cable insulation by setting up a main component and a cutting assembly, which prevents damage to cable core during the cutting process and enables the blade to cut at an angle, thereby improving cutting efficiency.

Abstract: The present invention discloses an electro-vibration coupled stress relief system, comprising a host computer, an arbitrary waveform card, a power amplifier, an electromagnetic exciter, an energy amplification device, an acceleration sensor, a charge amplifier, an oscilloscope, a power module, a charging module, an electric energy storage module, a discharge module, a pulse current sampling measurement module and a copper electrode.

Abstract: Disclosed is a prefabricated laminated slab made in accordance with a pretensioning fibermesh anti-cracking process and a manufacturing method thereof, and belongs to the technical field of fabricated structure engineering. The prefabricated laminated slab comprises a concrete layer, fiber grids, distribution bars and truss bars. The fiber grids are subjected to prestress tensioning and pouring to form a novel laminated slab with the pretensioning process, an overall pouring process of layered formworks is adopted, the construction problem during prestress tensioning of the fiber grids of the component can be effectively solved, the crack resistance of the laminated slab can be improved by adopting the prestress grids, the rigidity is increased, and the crack width under normal use conditions is reduced.

Abstract: Provided are a roller assembly, a battery cell manufacturing device, and an adjustment method of a roller, which relates to the field of battery manufacturing technology. The roller assembly includes a holder, a roller, and a first adjusting member. The roller is rotatably mounted on the holder. The first adjusting member is rotatably mounted on the holder, and one end of the roller is rotatably connected to the first adjusting member. A rotation axis of the roller does not coincide with a rotation axis of the first adjusting member. One end of the roller is rotatably mounted on the holder through the first adjusting member. The rotation axis of the first adjusting member does not coincide with the rotation axis of the roller, and therefore, rotation of the first adjusting member is capable of driving a corresponding end of the roller to rotate, thereby adjusting an extension direction of the roller.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: This application provides a communication method for a wireless fidelity Wi-Fi system and an apparatus, and relates to the field of communication technologies, to improve an anti-interference capability of an IoT device, and improve a coverage capability and a wall penetration capability. The communication method for a wireless fidelity Wi-Fi system includes: generating a Wi-Fi frame including a preamble, where a synchronization sequence of the preamble includes at least one extension code, and the extension code includes N symbols generated based on a Barker code, where N=?*M, M is a chip length of the Barker code, and ? is a positive integer; and transmitting the Wi-Fi frame.

Abstract: Operating an engine system includes autoigniting a first fuel including a plurality of liquid fuels premixed with air, to trigger ignition of a direct-injected main fuel in a first engine cycle, and receiving data indicative of an undesired heat release of combustion of the first fuel. The undesired heat release may include an undesired heat release rate (HRR) modality such as a multistage combustion. Relative amounts of the plurality of the liquid fuels are varied and admitted to the cylinder in a second engine cycle, and the first fuel having the varied relative amounts autoignited to trigger ignition of the direct-injected main fuel in the second engine cycle. The undesired heat release can be limited in the second engine cycle based on the varied relative amounts of the liquid fuels. The first fuel may include a blend of dimethyl ether (DME), methanol (MeOH), and water. The direct-injected main fuel may include MeOH and water. Related apparatus and control logic is also disclosed.

Abstract: An electrode assembly manufacturing device includes a winding mechanism, a heating mechanism, a conveyor belt arranged between the heating mechanism and the winding mechanism, and a forming mechanism. The winding mechanism is configured to wind a positive electrode sheet, a separator, and a negative electrode sheet into an electrode assembly. The conveyor belt is configured to transfer the electrode assembly from the winding mechanism to the heating mechanism. The heating mechanism is configured to heat the electrode assembly. The forming mechanism is configured to press and form the electrode assembly.

Abstract: A display panel includes heating lines each including part located in a display region, and a heating bus and a power supply pin located in a non-display region. The heating bus is electrically connected to the power supply pin and the heating lines. The display region includes first and second sub-regions, the heating lines include first and second heating lines. One first heating line is located in the first sub-region. One second heating line is located in the second sub-region. A length of the heating bus connected between one first heating line and the power supply pin is greater than a length of heating bus connected between one second heating line and the power supply pin. An arrangement density of first heating line is greater than that of the second heating line, or a resistance of the first heating line is smaller than that of the second heating line.