Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: A circuit includes a power supply node, a reference node, an output node, a first transistor coupled between the power supply and output nodes, and an amplifier including a non-inverting input coupled to the power supply node through a first passive device, an inverting input coupled to the reference node through a second passive device, and an output coupled to a gate of the first transistor. A first inverter is coupled between the output and reference nodes and generates a mode control signal responsive to a mode select signal, a first switching device is configured to, responsive to the mode control signal, selectively couple the non-inverting input of the amplifier to the reference node through a third passive device, and a second switching device is configured to, responsive to the mode control signal, selectively couple the inverting input of the amplifier to the output node through a fourth passive device.

Abstract: A circuit includes an output node and an amplifier and first and second branches coupled between power supply and reference nodes. The first branch includes a first switching device coupled between a first amplifier input and the reference node, the second branch includes a second switching device coupled between the output node and a second amplifier input, and a third switching device is coupled between the power supply and output nodes. Responsive to a first voltage level on the power supply node, each of the first and second switching devices is switched off and the third switching device is switched on, and responsive to a second voltage level on the power supply node greater than the first voltage level, each of the first and second switching devices is switched on and the third switching device is switched off.

Abstract: A circuit (to shape a follower voltage for a follower circuit) includes a tie-low circuit and an anti-noise circuit. The tie-low circuit is connected between a follower node and a first reference voltage. The tie-low circuit is responsive to a second reference voltage. The follower node is connectable to the follower circuit. The anti-noise circuit is connected between the follower node and the second reference voltage. The anti-noise circuit is configured to protect the follower voltage at the follower node from otherwise being distorted by a noise voltage being coupled capacitively to the follower node.

Abstract: A circuit includes an output node and an amplifier and first and second branches coupled between power supply and reference nodes. The first branch includes a first switching device coupled between a first amplifier input and the reference node, the second branch includes a second switching device coupled between the output node and a second amplifier input, and a third switching device is coupled between the power supply and output nodes. Responsive to a first voltage level on the power supply node, each of the first and second switching devices is switched off and the third switching device is switched on, and responsive to a second voltage level on the power supply node greater than the first voltage level, each of the first and second switching devices is switched on and the third switching device is switched off.

Abstract: A circuit includes a first passive device between supply and bias nodes, a first switching device and a second passive device between the bias and a reference node, a transistor between the supply and an output node, a third passive device and a second switching device between the output and a feedback node, a fourth passive device between the feedback and reference nodes, a third switching device between the supply and output nodes, and an amplifier controlling the transistor based on bias node and feedback node voltages. In a first mode, the first and second switching devices are off, the third switching device is on, and the supply node receives a first voltage level. In a second mode, the first and second switching devices are on, the third switching device is off, and a second voltage level greater than the first voltage level is received on the supply node.

Abstract: Disclosed is a friction-reducing and anti-wear composite material for a wading kinematic pair and a method of preparing the same. The friction-reducing and anti-wear composite material is prepared from carbon fiber (CF) among inorganic fillers, polyimide (PI) and polyether ether ketone (PEEK). These three materials are wet-mixed, dried and placed in a mold followed by curing by a heat press. The cured product is cooled and demolded to obtain the CF/PI/PEEK friction-reducing and anti-wear composite material for a wading kinematic pair. Tribological properties of the PEEK material are enhanced due to synergistic effect arising from hybrid organic-inorganic filling. The friction-reducing and anti-wear composite material provided in the invention has significantly reduced friction coefficient and wear volume loss under the seawater environment.

Abstract: A circuit includes a first passive device between supply and bias nodes, a first switching device and a second passive device between the bias and a reference node, a transistor between the supply and an output node, a third passive device and a second switching device between the output and a feedback node, a fourth passive device between the feedback and reference nodes, a third switching device between the supply and output nodes, and an amplifier controlling the transistor based on bias node and feedback node voltages. In a first mode, the first and second switching devices are off, the third switching device is on, and the supply node receives a first voltage level. In a second mode, the first and second switching devices are on, the third switching device is off, and a second voltage level greater than the first voltage level is received on the supply node.

Abstract: Disclosed is a friction-reducing and anti-wear composite material for a wading kinematic pair and a method of preparing the same. The friction-reducing and anti-wear composite material is prepared from carbon fiber (CF) among inorganic fillers, polyimide (PI) and polyether ether ketone (PEEK). These three materials are wet-mixed, dried and placed in a mold followed by curing by a heat press. The cured product is cooled and demolded to obtain the CF/PI/PEEK friction-reducing and anti-wear composite material for a wading kinematic pair. Tribological properties of the PEEK material are enhanced due to synergistic effect arising from hybrid organic-inorganic filling. The friction-reducing and anti-wear composite material provided in the invention has significantly reduced friction coefficient and wear volume loss under the seawater environment.