Abstract: Disclosed in the present invention are a use of a combination of an anti-PD-L1 nanobody and a TLR7 small molecule agonist in anti-tumor treatment, and a PD-L1 and TLR7 double-targeting nanobody coupling drug, a preparation method therefor, and a use thereof. Specifically, disclosed in the present invention are a use and solution of a combination of an anti-PD-L1 nanobody and a derived protein thereof as well as a TLR7 small molecule agonist and a derived compound thereof in anti-tumor treatment. Meanwhile, disclosed in the present invention are design, preparation, and identification solutions for a novel PD-L1 and TLR7 double-targeting-nanobody drug conjugate and a derived molecule thereof, and an effect of the novel PD-L1 and TLR7 double-targeting nanobody drug conjugate in anti-tumor treatment. The PD-L1 and TLR7 double-targeting nanobody drug conjugate of the present invention can yield a significant antineoplastic efficacy in various transplantation tumor models.

Abstract: Various embodiments provide methods, apparatus, and computer readable medium for determining a malicious program. In an exemplary method, a specific application programming interface (API) within an application program can be obtained. Call logic for calling the specific API can be determined. The call logic can include a triggering event to trigger the specific API to be called, a feedback path provided after the specific API is called, or a combination thereof. Whether the application program is a malicious program can be determined according to the call logic.

Abstract: Various embodiments provide methods, apparatus, and computer readable medium for determining a malicious program. In an exemplary method, a specific application programming interface (API) within an application program can be obtained. Call logic for calling the specific API can be determined. The call logic can include a triggering event to trigger the specific API to be called, a feedback path provided after the specific API is called, or a combination thereof. Whether the application program is a malicious program can be determined according to the call logic.