Patents by Inventor Yonglie Chu

Yonglie Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intact hepatitis c virus and the method for culturing it in a vitro cell culture
    Publication number: 20040166488
    Abstract: The present invention relates to the establishment of an in vitro cell culture system for culturing the whole HCV proliferating virus by using molecular biology and gene recombinant technology. Said method comprises the step of amplifying from the serum of HCV patients the full-length HCV genome comprising the 98 nucleotides at the 3′ end of the genome; site-specific mutating the NS5A and NS5B of HCV genome; inserting a marker gene IRES-GFP expression cassette into the NS5B 3′ end in the mutated HCV genome; and transfecting the sensitive cells and culturing, to obtain the infectious HCV offspring virus.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 26, 2004
    Inventors: Hengli Tang, Yonglie Chu, Shulin Zhang