Abstract: The present disclosure featured compositions and methods related to the detection and molecular profiling of extracellular vesicles using optical probes, dual imaging approaches, and computationally programing-based image analysis methods. These compositions and methods leverage the unique optoelectrical properties of quantum dots, fluorescently labeled nanoparticles, and gold nanoparticles, which allow reliable, real-time detection of extracellular vesicles and vesicle surface bound or lumenal molecules at single vesicle level.

Abstract: The present disclosure provides methods for treating or preventing osteoarthritis in a subject in need thereof. In certain aspects, the methods include administering an inhibitor of insulin growth factor-1 (IGF-1) signaling to a joint of the subject in an amount effective to treat or prevent osteoarthritis. In certain aspects, the osteoarthritis treated or prevented by the methods disclosed herein may to be post-traumatic osteoarthritis.

Abstract: An example baby carrier includes an enclosure, a seat configured to receive a baby, a back frame, and a first support frame. The first support frame includes an extendable arm having a handle, a first hinged leg, and a first wheel mounted to the first leg. The baby carrier is configured to reversibly transition between at least a stowed mode, a stroller mode, and a carrier mode.

Abstract: An example baby carrier includes an enclosure, a seat configured to receive a baby, a back frame, and a first support frame. The first support frame includes an extendable arm having a handle, a first hinged leg, and a first wheel mounted to the first leg. The baby carrier is configured to reversibly transition between at least a stowed mode, a stroller mode, and a carrier mode.

Abstract: An improved baby carrier is disclosed that includes a support frame coupled to a seating assembly though a suspension mechanism to provide weight support for a baby or toddler. The baby carrier includes an attachment harness worn by an adult to provide non-slip coupling between the baby carrier and the adult. The baby carrier also includes a semi-rigid coupling between the seat and harness assembly, a seat height adjustment capability, a sturdy support frame configuration, and a braking system. The baby carrier is a structurally stable device, and during use, significantly reduces the load of carrying the baby or toddler on the adult. Further, the baby carrier can have a compact size in a “stowed mode” for mobility, and can be used to meet a variety of user needs and carrying scenarios.

Abstract: An improved baby carrier is disclosed that includes a support frame coupled to a seating assembly though a suspension mechanism to provide weight support for a baby or toddler. The baby carrier includes an attachment harness worn by an adult to provide non-slip coupling between the baby carrier and the adult. The baby carrier also includes a semi-rigid coupling between the seat and harness assembly, a seat height adjustment capability, a sturdy support frame configuration, and a braking system. The baby carrier is a structurally stable device, and during use, significantly reduces the load of carrying the baby or toddler on the adult. Further, the baby carrier can have a compact size in a “stowed mode” for mobility, and can be used to meet a variety of user needs and carrying scenarios.

Abstract: An improved baby carrier is disclosed that includes a support frame coupled to a seating assembly though a suspension mechanism to provide weight support for a baby or toddler. The baby carrier includes an attachment harness worn by an adult to provide non-slip coupling between the baby carrier and the adult. The baby carrier also includes a semi-rigid coupling between the seat and harness assembly, a seat height adjustment capability, a sturdy support frame configuration, and a braking system. The baby carrier is a structurally stable device, and during use, significantly reduces the load of carrying the baby or toddler on the adult. Further, the baby carrier can have a compact size in a “stowed mode” for mobility, and can be used to meet a variety of user needs and carrying scenarios.

Abstract: An improved baby carrier is disclosed that includes a monopod leg coupled to a sitting element for supporting the weight of a baby or toddler. In some implementations, the baby carrier includes a detachable sitting element coupled to the monopod leg to support the carrying load and an attachment harness to attach the sitting element and monopod leg to a carrying individual. The monopod leg can be telescopic and include controls for coarse and fine height adjustment of the sitting element, covering a range from, for example, below to above the waist level of the carrying individual. The attachment harness securely attaches the sitting element and monopod leg to a waistband worn by the carrying individual using an attachment cable. In some implementations, the attachment harness can include a baby waistband that attaches to the waistband and/or shoulder straps worn by the carrying individual using attachment cables and clips.

Abstract: An improved baby carrier is disclosed that includes a monopod leg coupled to a sitting element for supporting the weight of a baby or toddler. In some implementations, the baby carrier includes a detachable sitting element coupled to the monopod leg to support the carrying load and an attachment harness to attach the sitting element and monopod leg to a carrying individual. The monopod leg can be telescopic and include controls for coarse and fine height adjustment of the sitting element, covering a range from, for example, below to above the waist level of the carrying individual. The attachment harness securely attaches the sitting element and monopod leg to a waistband worn by the carrying individual using an attachment cable. In some implementations, the attachment harness can include a baby waistband that attaches to the waistband and/or shoulder straps worn by the carrying individual using attachment cables and clips.

Abstract: The described arrangements and procedures identify an image's orientation by extracting features from peripheral portions of the image. The procedure evaluates the extracted features based on training image feature orientation classification models to identify the image's orientation.

Abstract: The described arrangements and procedures identify an image's orientation by extracting features from peripheral portions of the image. The procedure evaluates the extracted features based on training image feature orientation classification models to identify the image's orientation.