Patents by Inventor Yongmei Xia

Yongmei Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12268782
    Abstract: The present disclosure discloses a preparation method of fatty acid-based VC liposomes, and belongs to the field of pharmaceutical preparations. In the disclosure, a complex of industrial conjugated linoleic acid and other fatty acids with sodium dodecyl sulfate is taken as a capsule material, which is self-assembled to embed vitamin C in an aqueous phase under an acidic condition (pH<7) to form the fatty acid-based vitamin C liposome. The preparation method of the disclosure does not use organic solvents and other substances harmful to the human body, and has the characteristics of safety and health. In addition to VC encapsulation under the acidic condition, the prepared fatty acid-based liposome can play a role in slowly releasing VC.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: April 8, 2025
    Assignee: Jiangnan University
    Inventors: Yongmei Xia, Huan Liu, Xinyu Meng, Yun Fang, Ye Fan, Jie Shen, Xiang Liu
  • Patent number: 12129219
    Abstract: Provided is a calcium-based catalyst and a method for catalytically synthesizing an alkanolamide surfactant thereof. The method includes the preparation of the catalyst, and then catalyzing a reaction of fat and oil, or fatty acid ester and alkanolamine with the catalyst to synthesize a light colored alkanolamide surfactant with less free alkanolamine. The catalyst has a slow release feature, so that late in the reaction, the catalyst still has relatively high catalytic reactivity, guaranteeing a high conversion rate of the alkanolamine into the alkanolamide surfactant, the, product residual quantity of alkanolamine is low, while the risk of nitrosamine production due to product residual alkanolamine is greatly lowered. Due to catalyst slow release control, the early reaction period speed is greatly reduced, thereby avoiding a deepened product color caused by poor heat transfer due to an early reaction period being excessively fast.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: October 29, 2024
    Assignee: Jiangnan University
    Inventors: Yun Fang, Xueyi Hu, Yongmei Xia
  • Patent number: 12116455
    Abstract: The disclosure discloses preparation and application of an alkylcyclohexanol polyoxyethylene ether emulsifier, and belongs to the technical field of surfactants. By performing ethylene oxide adducting on alkylcyclohexanol polyoxyethylene ether (1-3) and using a strong alkaline suspension dispersed in the solvent and alkylcyclohexanol polyoxyethylene ether (1-3) as a catalyst, nonionic surfactants alkylcyclohexanol polyoxyethylene ether (5-17) are synthesized. The products all have good characteristics of nonionic surfactants, and contain lower content of polyethylene. The products such as nonylcyclohexanol ethoxylate (7) and nonylcyclohexanol ethoxylate (9) have emulsifying properties similar to the emulsifying property of nonylphenol ethoxylate (10), and therefore can substitute for nonylphenol ethoxylate (10) as an emulsifier.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: October 15, 2024
    Assignee: Jiangnan University
    Inventors: Yongmei Xia, Yun Fang, Xueyi Hu, Conglin Ren, Fei Qian, Yitao Hu, Xinyu Meng
  • Patent number: 12012628
    Abstract: The disclosure discloses a method to elevate the amount of steviol glycosides remained in the recrystallization mother liquor of Stevia extract, and belongs to the field of modification and extraction of natural compounds. The disclosure adopts lactase for highly specific catalytic hydrolysis of stevioside to convert stevioside into rubusoside which usually can only be obtained from leaves of Rubus suavissimus S. Lee; and meanwhile, after stevioside in the mother liquor glycosides is converted, since the polarity difference between rubusoside and rebaudioside A is far larger than the polarity difference between stevioside and rebaudioside A, rebaudioside A is more easily separated out of the mother liquor glycosides. A technology provided by the disclosure is also applicable to value increment of mixed steviol glycosides containing stevioside and is beneficial for separating out rebaudioside A from the mixed steviol glycosides.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: June 18, 2024
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Yongmei Xia, Zhuoyu Zhou, Ye Fan, Xueyi Hu, Yun Fang, Xiang Liu, Haijun Wang, Jing Wu, Fei Xu
  • Publication number: 20220183974
    Abstract: The present disclosure discloses a preparation method of fatty acid-based VC liposomes, and belongs to the field of pharmaceutical preparations. In the disclosure, a complex of industrial conjugated linoleic acid and other fatty acids with sodium dodecyl sulfate is taken as a capsule material, which is self-assembled to embed vitamin C in an aqueous phase under an acidic condition (pH<7) to form the fatty acid-based vitamin C liposome. The preparation method of the disclosure does not use organic solvents and other substances harmful to the human body, and has the characteristics of safety and health. In addition to VC encapsulation under the acidic condition, the prepared fatty acid-based liposome can play a role in slowly releasing VC.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Yongmei XIA, Huan LIU, Xinyu MENG, Yun FANG, Ye FAN, Jie SHEN, Xiang LIU
  • Patent number: 11242550
    Abstract: The present invention discloses a method for preparing glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput, belonging to the technical field of biosynthesis of sweeteners. By using cyclodextrin glucosyltransferase from Geobacillus sp. as a catalyst, steviol glycosides as the glycosyl receptor and dextrin or oligosaccharide as the glycosyl donor, taking a calcium/barium ion salt bridge as the main stabilizer and combining with glycerol to adjust the conformation and binding domain openness of the enzyme, and utilizing transglucosylation and hydrolytic activities of amylase at variable temperatures in different stages, thereby preparing the glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput. The technology of the present invention can improve the utilization rate of the enzyme, and obtain glucosyl steviol glycosides with good sweetness and good taste.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 8, 2022
    Assignees: Jiangnan University, DONGTAI HAORUI BIOTECHNOLOGY CO., LTD.
    Inventors: Yongmei Xia, Liping Zhu, Yun Fang, Xiang Liu, Haijun Wang
  • Patent number: 11180788
    Abstract: The present invention discloses a method for preparing lower graft degree GSGs, and belongs to the technical field of biosynthesis of sweeteners. The method uses amylase to catalyze hydrolysis of GSGs with a high graft degree, thereby obtaining GSGs with low graft degree mainly containing GSGs with a low grafting number. The content of mono- and di-glucosyl substituents in the SGs in the product was 60% or more of the total glycosides, and the mass percent of the GSGs with a glucosyl grafting number of 3 or less was higher than 70% of the total glycosides. The mono- and di-substituted GSGs obtained by enzyme catalysis by the present invention were structurally similar to those, belong to a mixture of the isomers thereof, and have good sweetness and a flavoring function.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 23, 2021
    Assignees: Jiangnan University, Dongtai Haorui Biotechnology Co., Ltd.
    Inventors: Yongmei Xia, Liping Zhu, Tongtong Zhang, Guoying Du, Xiang Liu, Yun Fang
  • Publication number: 20210087334
    Abstract: The disclosure discloses preparation and application of an alkylcyclohexanol polyoxyethylene ether emulsifier, and belongs to the technical field of surfactants. By performing ethylene oxide adducting on alkylcyclohexanol polyoxyethylene ether (1-3) and using a strong alkaline suspension dispersed in the solvent and alkylcyclohexanol polyoxyethylene ether (1-3) as a catalyst, nonionic surfactants alkylcyclohexanol polyoxyethylene ether (5-17) are synthesized. The products all have good characteristics of nonionic surfactants, and contain lower content of polyethylene. The products such as nonylcyclohexanol ethoxylate (7) and nonylcyclohexanol ethoxylate (9) have emulsifying properties similar to the emulsifying property of nonylphenol ethoxylate (10), and therefore can substitute for nonylphenol ethoxylate (10) as an emulsifier.
    Type: Application
    Filed: December 7, 2020
    Publication date: March 25, 2021
    Inventors: Yongmei XIA, Yun FANG, Xueyi HU, Conglin REN, Fei QIAN, Yitao HU, Xinyu MENG
  • Publication number: 20210087136
    Abstract: The present disclosure discloses a calcium-based catalyst and a method for catalytically synthesizing an alkanolamide surfactant thereof, and belongs to the technical field of surfactant synthesis. In the present disclosure, the compounded calcium-based catalyst is prepared, and the calcium-based catalyst is utilized to catalyze reaction of fat and oil or fatty acid ester and alkanol amine to synthesize the alkanolamide surfactant with light color and less free alkanol amine, which facilitates application in daily chemicals.
    Type: Application
    Filed: December 7, 2020
    Publication date: March 25, 2021
    Inventors: Yun FANG, Xueyi HU, Yongmei XIA
  • Publication number: 20210079437
    Abstract: The disclosure discloses a method to elevate the amount of steviol glycosides remained in the recrystallization mother liquor of Stevia extract, and belongs to the field of modification and extraction of natural compounds. The disclosure adopts lactase for highly specific catalytic hydrolysis of stevioside to convert stevioside into rubusoside which usually can only be obtained from leaves of Rubus suavissimus S. Lee; and meanwhile, after stevioside in the mother liquor glycosides is converted, since the polarity difference between rubusoside and rebaudioside A is far larger than the polarity difference between stevioside and rebaudioside A, rebaudioside A is more easily separated out of the mother liquor glycosides. A technology provided by the disclosure is also applicable to value increment of mixed steviol glycosides containing stevioside and is beneficial for separating out rebaudioside A from the mixed steviol glycosides.
    Type: Application
    Filed: November 27, 2020
    Publication date: March 18, 2021
    Inventors: Yongmei XIA, Zhuoyu ZHOU, Ye FAN, Xueyi HU, Yun FANG, Xiang LIU, Haijun WANG, Jing WU, Fei XU
  • Patent number: 10836984
    Abstract: This disclosure provides a method for stabilizing both lipase and protease in liquid enzymatic laundry detergent, comprising steps of: first, self-assembling conjugated linoleic acid with protease and lipase, respectively, to form vesicles encapsulated protease and vesicles encapsulated lipase at a low Ca2+ concentration; then, mixing the solution of vesicles encapsulated protease and the solution of vesicles encapsulated lipase, and then partially cross-linking conjugated linoleic acid molecules on the vesicles' surface. The obtained enzyme vesicles, after being concentrated, can be used directly in liquid laundry detergent. The lipase in the liquid laundry detergent will not be degraded by protease, and the enzymes in vesicles are able to resist against surfactant inhibition. Thus, the enzyme activities can be maintained in the liquid laundry detergent, and the enzymatic vesicles will be broken to release enzymes, when the liquid laundry detergent is used at a higher Ca2+ concentration such as in tap water.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: November 17, 2020
    Assignee: Jiangnan University
    Inventors: Yun Fang, Yongmei Xia, Bei Wei, Yinxing Yan
  • Patent number: 10557159
    Abstract: The present invention provides a method to produce RD by using a cutinase to catalyze the esterification of RB under stepwise cooling temperatures, which is related to the field of biosynthesis of organic compounds. The method uses a cutinase from Thermobifida fusca to catalyze the esterification of RB and sophorose to produce RD. The stepwise cooling temperatures are used to reduce the heat inactivation of the enzyme as well as to improve the mass transfer. The method catalyzes the esterification of RB to produce RD in a solvent such as methanol, DMSO and DMF. The reaction is safe, efficient and highly selective. In addition, the method uses stepwise additions of substrate RB and cooling temperatures for the esterification reaction. In this way, it speeds up the initial reaction rate, increases the amount of solved RB as it is converted to RD, and improves the mass transfer to further increase the reaction speed.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 11, 2020
    Assignee: Jiangnan University
    Inventors: Yongmei Xia, Yun Fang, Haijun Wang
  • Publication number: 20190352688
    Abstract: The present invention discloses a method for preparing lower graft degree GSGs, and belongs to the technical field of biosynthesis of sweeteners. The method uses amylase to catalyze hydrolysis of GSGs with a high graft degree, thereby obtaining GSGs with low graft degree mainly containing GSGs with a low grafting number. The content of mono- and di-glucosyl substituents in the SGs in the product was 60% or more of the total glycosides, and the mass percent of the GSGs with a glucosyl grafting number of 3 or less was higher than 70% of the total glycosides. The mono- and di-substituted GSGs obtained by enzyme catalysis by the present invention were structurally similar to those, belong to a mixture of the isomers thereof, and have good sweetness and a flavoring function.
    Type: Application
    Filed: July 30, 2019
    Publication date: November 21, 2019
    Inventors: Yongmei XIA, Liping ZHU, Tongtong ZHANG, Guoying DU, Xiang LIU, Yun FANG
  • Publication number: 20190218585
    Abstract: The present invention discloses a method for preparing glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput, belonging to the technical field of biosynthesis of sweeteners. By using cyclodextrin glucosyltransferase from Geobacillus sp. as a catalyst, steviol glycosides as the glycosyl receptor and dextrin or oligosaccharide as the glycosyl donor, taking a calcium/barium ion salt bridge as the main stabilizer and combining with glycerol to adjust the conformation and binding domain openness of the enzyme, and utilizing transglucosylation and hydrolytic activities of amylase at variable temperatures in different stages, thereby preparing the glucosyl steviol glycosides through enzymatic catalysis under programming temperatures in high throughput. The technology of the present invention can improve the utilization rate of the enzyme, and obtain glucosyl steviol glycosides with good sweetness and good taste.
    Type: Application
    Filed: December 5, 2018
    Publication date: July 18, 2019
    Inventors: Yongmei XIA, Liping ZHU, Yun FANG, Xiang LIU, Haijun WANG
  • Publication number: 20180320112
    Abstract: This disclosure provides a method for stabilizing both lipase and protease in liquid enzymatic laundry detergent, comprising steps of: first, self-assembling conjugated linoleic acid with protease and lipase, respectively, to form vesicles encapsulated protease and vesicles encapsulated lipase at a low Ca2+ concentration; then, mixing the solution of vesicles encapsulated protease and the solution of vesicles encapsulated lipase, and then partially cross-linking conjugated linoleic acid molecules on the vesicles' surface. The obtained enzyme vesicles, after being concentrated, can be used directly in liquid laundry detergent. The lipase in the liquid laundry detergent will not be degraded by protease, and the enzymes in vesicles are able to resist against surfactant inhibition. Thus, the enzyme activities can be maintained in the liquid laundry detergent, and the enzymatic vesicles will be broken to release enzymes, when the liquid laundry detergent is used at a higher Ca2+ concentration such as in tap water.
    Type: Application
    Filed: February 2, 2018
    Publication date: November 8, 2018
    Inventors: Yun FANG, Yongmei XIA, Bei WEI, Yinxing YAN
  • Publication number: 20180073049
    Abstract: The present invention provides a method to produce RD by using a cutinase to catalyze the esterification of RB under stepwise cooling temperatures, which is related to the field of biosynthesis of organic compounds. The method uses a cutinase from Thermobifida fusca to catalyze the esterification of RB and sophorose to produce RD. The stepwise cooling temperatures are used to reduce the heat inactivation of the enzyme as well as to improve the mass transfer. The method catalyzes the esterification of RB to produce RD in a solvent such as methanol, DMSO and DMF. The reaction is safe, efficient and highly selective. In addition, the method uses stepwise additions of substrate RB and cooling temperatures for the esterification reaction. In this way, it speeds up the initial reaction rate, increases the amount of solved RB as it is converted to RD, and improves the mass transfer to further increase the reaction speed.
    Type: Application
    Filed: June 8, 2017
    Publication date: March 15, 2018
    Applicant: Jiangnan University
    Inventors: Yongmei Xia, Yun Fang, Haijun Wang