Abstract: Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3?-phosphoadenosine 5?-phosphosulfate (PAPS); and incubating a polysaccharide substrate with the at least one OST and the reaction mixture, whereby the HS-like compounds are synthesized. Also disclosed are methods of synthesizing a library of HS-like compounds and methods of determining the mechanism of activity of HS-like compounds.

Abstract: Historical access information identifies which resources in a storage area network access portions of shared storage in the storage area network. Based on an analysis of the historical access information, a management report generator application analyzing such information can infer the existence of a cluster of resources that access a common portion of shared storage. When the management report generator identifies that two or more resources access the same storage resources during approximately the same timeframe, the management report generator knows that there is a high likelihood that the two or more resources are part of a cluster sharing access to common storage resources. Thus, when reporting a tally of storage resources used in the storage area network, it is possible for the management report generator to take into account the cluster and indicate that two resources share access to a common portion of storage.