Abstract: A plasma arc-laser hybrid welding method for a high-sealing aluminum alloy thick plate rectangular chamber is provided. A length, height and width of the rectangular chamber of the high-sealing aluminum alloy thick plate are all ?350 mm. The aluminum alloy tensile plate material for the chamber is AL6061-T6, the plate thickness is 20 mm-25 mm, and the adjacent plates are in accordance with T The welding wire material is 4043, the diameter of the welding wire is ?1.2 mm, the height and width of the welding seam are required to be greater than 5 mm, the welding seam quality meets GB\12469-1990, and the ultimate vacuum degree of the chamber reaches 1 Pa. It greatly improves the material utilization rate and processing efficiency, and reduces the material and cycle cost. Using hybrid welding technology, compared with single laser welding and plasma welding, the welding quality is effectively improved.